Synthesis, characterization, and antimicrobial activity of some thiazole derivatives

Document Type : Original Article


1 Department of Chemistry, College of Science, University of Misan, Maysan, Iraq

2 Department of Chemistry, College of Science, University of Misan, Misan, 62001. Iraq


Thiazole derivatives 2a-c were synthesized via reaction of 2-chloro-N-phenylacetamide (1) and thiourea, thiosemicarbazide or thioacetamide in alcoholic potassium hydroxide. Also, substituted benzaldehyde reacted with thiosemicarbazide at reflux temperature in ethanol to afford hydrazone compounds 3a-k. Under microwave irradiation (M.I., 100W) with neat for 20sec; arylketones, thiosemicarbazide and chloroacetylchloride were reacted to afford thiazole derivatives 4a-j. Compounds are characterized by physical measurements, NMR and infrared spectra. Antibacterial activity of new compounds was evaluated with Gram Negative Serratia marcesence, Proteus vulgaris, Escherichia coli and Psudomonas aeruginosa and Gram Positive; Staphylococcus aureus in comparison with Norfloxacin and Ciprofloxacin as standard drugs.


Main Subjects

  • Receive Date: 26 October 2021
  • Revise Date: 24 November 2021
  • Accept Date: 25 November 2021
  • First Publish Date: 25 November 2021