Enhanced Antioxidant Activity of Di- and Triorganotin Complexes Derived from Mefenamic Acid

Hashim, Dhekra Jawad; Falah, Tamara F; Hadi, Angham G.

doi:10.21608/ejchem.2021.82292.4056

Enhanced Antioxidant Activity of Di- and Triorganotin Complexes Derived from Mefenamic Acid

Document Type : Original Article

Authors

¹ Technical Institute of Babylon ,Al-Furat Al-Awsat Technical University, Babylon, Iraq

² Department of Engineering Medical Device Technologies , Hilla university college , Babylon , Iraq

³ Chemistry department/ College of science/ University of Babylon

10.21608/ejchem.2021.82292.4056

Abstract

Organotin(IV) compounds have gained significant interest in both the chemical and pharmaceutical industry. This research concentrates on synthesis of di and tri-organotin complexes with mefenamic acid and characterized with different techniques such as elemental analysis, FTIR, proton and carbon NMR. The anti-oxidant properties of the complexes were assessed using the 1,1-diphenyl-2-picrylhydrazyl, DPPH and CUPRAC Method . The complexes' scavenging activities were assessed and compared to those of the free drug. The synthesized complexes gives higher antioxidant activity than free drug, also, complex 3 of di methyltin-mefenamic was the highest as compared with the other complexes.

Keywords