Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies

Ahmed, Ahmed; Majeed, Ismaeel Y.; Asaad, Noora; Ahmed, Riyadh Mahmood; Kamil, Ghada M.; Abdul Rahman, Sarah

doi:10.21608/ejchem.2021.93025.4397

Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.

² Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq

³ Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq.

⁴ Department Of Applied sciences, Branch of Applied Chemistry, University Of Technology, Baghdad, Iraq.

10.21608/ejchem.2021.93025.4397

Abstract

Methyl 4-aminopicolinate 1 interacted with hydrazine hydrate and subsequently with carbon disulfide to produce a triazole thiol derivative, which then reacted with different aldehydes to produce the appropriate Schiff base products. 4a-c. The reaction of Schiff base products 4a-c with benzoyl chloride resulted in the formation of trisubstituted triazoles 5a-c. The spectroscopic studies of the produced chemicals helped to clarify their structures. The antibacterial activity of the produced compounds against various bacterial and fungal strains was tested. Molecular docking studies of newly synthesized 1,2,4-triazoles were also conducted.

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