Document Type : Original Article
Faculty of science menoufia university shebien ElKoom Egypt
Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt
Photochemistry Department, National Research Centre
As an important strategy, including incorporation of more than active core in one molecule, for finding potent candidates against cancer cells, a number of functionalized pyrazolopyridin derivatives linked to oxadiazole, dioxolane, acyclic sugar and fluorene ring systems, were synthesized through heterocyclization reactions. The derived sugar hydrazone and the corresponding acyclic C-nucleoside analog in addition to acyclic N-nucleoside were also prepared. The behavior of the afforded compounds as possible cytotoxic agents against human HTC116 and MCF7 cancer cells was investigated and the results showed that compounds 11-13 showed the highest activities against the two cancer cells. Other compounds revealed a type of selectivity toward one cancer cell while the activity was relatively lost against the other cancer cell line.