Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

Ewies, Ewies; El-Sayed, Naglaa Fathy; El-Hussieny, Marwa; Abdelaziz, Mohamed

doi:10.21608/ejchem.2021.88648.4263

Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

Document Type : Original Article

Authors

¹ Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

² Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.

³ Organometallic and Organometalloid Chemistry Department, Chemical Industries Division, NRC, Egypt.

⁴ Microbial Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

10.21608/ejchem.2021.88648.4263

Abstract

5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, and dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from the reaction of Luminol (1) with thiating Lawesson and Japanese reagents. Structures of the synthesized compounds were clarified based on their elemental and spectroscopic analyses. The synthesized compounds were evaluated for their antimicrobial activity against some bacterial and fungal strains.

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