Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

Document Type : Original Article

Authors

1 NRC_Photochemistry

2 photochemistry, NRC, Egypt, Cairo

3 El Buhouth St., Dokki 12622

4 national research centre

5 Therapeutic Chemistry Dept. National Research Centre, Elbehouth St. Dokki, Giza, Egypt.

6 Photochemistry Department, Industrial Research Division, national research Centre, Dokki, Cairo, Egypt

Abstract

Green chemistry is among the important applied aspects to synthesize novel bioactive compounds. We aim to provide triazole derivatives using eco-friendly methods such as sonication technology. This procedure was performed by using natural catalysts such as natural citrus squeezes. Ultrasonic irradiation was employed in the presence of natural juices such as lemon or/and orange juice to synthesize triazole derivatives. The synthesized compounds were investigated using FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The cytotoxicity and in vitro anticancer evaluation of the synthesized triazole derivatives and the derivatives selenium nanoparticles have been assessed towards human liver cancer cell line (HEGP2) in addition to BALB/3T3 (murine fibroblast) normal cell line. Some compounds showed an active selectivity towards the human liver cancer cell line (HEGP2). However, they have no activity for the BALB/3T3 (murine fibroblast) normal cell line. Meanwhile, after evaluating the cytotoxicity of the synthesized compounds and in vitro anticancer activities, compounds 12a, 12b, 13a, 13b were selected to contribute in synthesizing in-situ selenium nanoparticles (SeNPs). The results showed a significant in vitro antiproliferative activity of the synthesized compounds.

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History

  • Receive Date: 17 June 2021
  • Revise Date: 28 June 2021
  • Accept Date: 11 July 2021

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