Synthesis, Characterization of Some Copper (II) Complexes with Ampicillin Derivatives and Study their Biological Activity

Document Type : Original Article

Authors

1 Chemistry, science faculty, university of Basrah, Iraq

2 Chemistry, Science faculty, university of Basrah, Iraq

3 Chemistry, Science faculty, University of Basrah, Iraq

Abstract

New metal ion complexes of ampicillin were synthesis by two steps, first by N-acylation with benzoyl chloride and sebacoyl chloride, In the second step, the prepared compounds were reacted with cupric ion to form Cu- complexes. FT-IR, 1H NMR, 13C NMR, UV- visible, Elemental analysis, and, a theoretical study was used to distinguish the prepared complexes. The biological efficacy of synthesis compound was found more active against the bacteria.

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