Docking and Synthesis of Some 2-Aminothiazole Derivatives as Antimicrobial Agents

Document Type : Original Article

Authors

1 Department of Chemistry, College of Education for Pure Science,

2 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.

Abstract

The 2- aminothiazole compounds are medicinally important agents due to their broad spectrum of biological activities. This study aims to design new 2-aminothiazole derivatives, docking, and synthesis via several steps and identified using physical and spectroscopic techniques. The bioactivities of the synthesized compounds were evaluated concerning their antimicrobial activities against were screened against five bacterial strains, Enterobact aerogenes, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus and two types of fungal strain Candida albicans and Cryptococcus neoformans var. grubii.

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History

  • Receive Date: 05 June 2021
  • Revise Date: 18 June 2021
  • Accept Date: 20 June 2021

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