Using Microwave and ultrasound to prepare of substituted Bis-acyl hydrazone Derivatives

Document Type : Original Article


1 Department of Chemistry, College of Science, Mosul University, Mosul, Iraq

2 Department of Biochemistry, College of Medicine, Mosul University, Mosul-Iraq


In this paper, some new bis-aryl hydrazone derivatives (4a-f) were prepared through the reaction of carboxylic acid hydrazides with 1,4-diacetylbenzene using classical methods, microwave and ultrasound irradiation methods. These compounds are obtained through a series of reactions where some carboxylic acids react with ethanol first in the presence of concentrated sulfuric acid to give the corresponding esters (2a-f), which when treatment with aqueous hydrazine give carboxylic acid hydrazides (3a-f).thus, The results proved that the use of microwave and ultrasound techniques is much better than the classical methods, as it gave a higher yield, shorter reaction time, and the absence of the use of solvents. All newly synthesized compounds were confirmed by IR, (1H & 13C) NMR spectral analysis and the corresponding reactions were
monitored by TLC using the reported eluent


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