Outcomes of Pregnancy in Euthyroid Women with Positive Thyroid Peroxidase Antibodies

Document Type : Original Article

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Department of Biochemistry, College of Medicine,University of Mosul, Mosul, Iraq

Abstract

Thyroid disorders are among the most common endocrine disorders affecting pregnant women .Thyroid autoimmunity has been associated with poor pregnancy outcomes. Thyroid Peroxidase antibodies being the most common of thyroid antibodies and it can be considered as a surrogate marker for thyroid related adverse pregnancy outcomes. The present study was conducted to further elucidate the association between these antibodies and adverse pregnancy outcomes. A case control study including 150 randomly selected participant was carried out at AL-Khansaa Teaching Hospital in Mosul, Iraq. over the period of three months. All participants enrolled in the study were screened for Thyroid Function Tests TFTs including Thyroid Stimulating Hormone, Free thyroid hormones (Ft3 and Ft4) as well as Anti-Thyroid Peroxidase antibodies. Pregnant women were then classified depending on their Anti-Thyroid Peroxidase antibodies test results into two groups (positive and negative) groups. All women were followed till delivery to record their pregnancy outcomes. Our results showed that 10% of the screened pregnant women showed positive anti-Thyroid peroxidase antibodies. These women reported a higher incidence of cesarean section and preterm deliveries when compared to negative anti-Thyroid peroxidase antibodies control group. So a conclusion was drawn to recommend anti-Thyroid peroxidase antibodies as screening test during pregnancy especially those with bad obstetric history or history of thyroid disorders.

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History

  • Receive Date: 22 May 2021
  • Revise Date: 02 June 2021
  • Accept Date: 08 June 2021

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