Spectrophotometric Determination of Catechol and Resorcinol By Oxidative Coupling With 2,4-Dinitrophenyl Hydrazine

Document Type : Original Article

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Department of Chemistry, Education College for Girls, University of Mosul-Iraq.

Abstract

A simple, fast and sensible spectrophotometric method was developed for the determination of carvedilol. The method is based on the oxidative coupling reaction of the compound with phenothiazine in the presence of potassium dichromate as oxidant to form a stable pink-red color product showing maximum absorption at 551nm. Molar absorptivities are 1.625 ×104 l. Mol-1, cm-1. The Beer law has been complied with in a range from (1 to 12) ppm. This method has been successfully applied to carvedilol analysis in various pharmaceutical formulations.

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History

  • Receive Date: 16 January 2021
  • Revise Date: 11 February 2021
  • Accept Date: 22 April 2021

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