A Pd-Np/Ac‐Catalyzed Transfer-Hydrogenation of Mesityl Oxide to Methyl Isobutyl Ketone using Sodium Formate as Hydrogen Donor

Sumiarsa, Dadan; Maharani, Rani; Zainuddin, Achmad; Hidayat, Ace Tatang; Nurhilal, Otong

doi:10.21608/ejchem.2021.65929.3416

A Pd-Np/Ac‐Catalyzed Transfer-Hydrogenation of Mesityl Oxide to Methyl Isobutyl Ketone using Sodium Formate as Hydrogen Donor

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Indonesia

² Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran

³ Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran

10.21608/ejchem.2021.65929.3416

Abstract

Methyl isobutyl ketone (MIBK) is an α,β-unsaturated carbonyl compound, which is often used as solvent and extractor for antibiotics in the pharmaceutical industry. One alternative to the synthesis of MIBK from mesityl oxide (MO) is through catalytic transfer hydrogenation (CTH) using various organic compounds as hydrogen donors in the presence of a catalyst. The purpose of this study was to synthesize MIBK from MO through the CTH reaction using sodium formate as the hydrogen donor and Pd nanoparticles deposited on the activated charcoal (Pd-NP/AC) as the catalyst. Based on the Gas Chromatography-Mass Spectrometry (GC-MS) analysis, the conversion value of MO was obtained in 97.3% and the yield of the MIBK formation was 10.5%. Meanwhile, the highest selectivity was obtained in 17% at 40° C. The results show that sodium formate can effectively be used to reduce MO into MIBK in the presence of Pd-NP/AC catalyst at 70° C for 5 hours.

Keywords