Antioxidant and Anti-Inflammatory Activity of Red Ginger (Zingiber officinale Roscoe var. Sunti Val) Essential Oil Distillation Residues

Document Type : Original Article


1 Jl tubagus ismail video no 17

2 Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Ganeca Street 10 Bandung 40132, Indonesia

3 Institut Teknologi Bandung, Bandung, Indonesia

4 Department of Pharmacology, School of Pharmacy, Institut Teknologi Bandung, Ganeca Street 10 Bandung 40132, Indonesia


Natural resources are the main assets for drug development. Red ginger, a gift from nature proven to have pharmacological activities are widely used in traditional medicine. However, the process of its oil refining by traditional method produces heaps of residue unprocessed, causing excessive waste of chemical contents that may have pharmacological activity. Thus, this study aims to create an extraction model to utilize these residues and access its antioxidant and anti-inflammatory activity. 2,2'-azinobis (3-ethylbenzothiazolinone-6-sulfonic acid) (ABTS),1-diphenyl-2-picrylhydrazyl (DPPH), and lipoxygenase inhibition activity methods were used. Results showed the use of liquid-liquid extraction method with ethyl acetate solvent produced a fraction abundance with 6-gingerol. Antioxidant activity accessed by ABTS and DPPH methods showed the ethyl acetate fraction collected from red ginger residues gave inhibition concentrations (IC50) of 27.95 ± 2.69 µg/ml and 32.83 ± 1.61 µg/ml respectively. The strongest lipoxygenase inhibitory activity is also shown by its ethyl acetate fraction (IC50 77.23 ± 8.14 µg/ml). These potent antioxidant activities could be caused by its 6-gingerol content (201.38 ± 6.77 ppm/µg extract). In conclusion, the proposed method provides the opportunity for further utilization of red ginger distillation residues. Based on antioxidant capacity and anti-inflammatory properties, ethyl acetate fraction collected from distillation residues has the potential to be developed as an antihyperlipidemic drug, given its 6-gingerol content which prevents lipid peroxidation.


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