Chemical constituents from Sarcostemma acidum (Roxb.) Voigt

Document Type : Original Article

Authors

1 Chemical Science and Technology Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India

2 Department of Chemistry, Sikkim Manipal University (Sikkim Manipal Institute of Technology), Majitar 737136, Sikkim, India

Abstract

Sarcostemma acidum (Roxb.) Voigt is a valuable medicinal plant to treat a number of diseases in India. Four compounds were isolated from the whole plant of S. acidum. The structures were characterized as Friedelin (1), β-amyrin (2), β-sitosterol (3) and 4α-Carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol (4) by extensive spectroscopic (NMR, FT-IR and mass) analysis and compared their spectral data with literature. The in vitro anti-inflammatory activity of isolated compounds (1-4) and extract of S. acidum was carried out against the denaturation of protein using egg albumin method compared with standard dichlofenac sodium. The compounds showed the inhibition of protein denaturation in a concentration dependent manner.

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History

  • Receive Date: 08 February 2021
  • Revise Date: 22 February 2021
  • Accept Date: 20 April 2021

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