Ex-vivo Antimalarial and in-vitro Biological Activities of newly synthesized Co(II) complex with Schiff base

Document Type : Original Article

Authors

1 DEPARTMENT OF CHEMISTRY, GOVT ARTS COLLEGE, ARIYALUR-621713. TAMIL NADU, INDIA

2 Department of Chemistry, Govt Arts College, Ariyalur, Tamil Nadu, India

3 Department Of Chemistry, Govt Arts College, Tamil Nadu, India

Abstract

Abstract
The first-row transition metal complex of Schiff base has been synthesized and characterized based on physicochemical spectral and biochemical methods. The metal-ligand stoichiometry and molecular formula of the complex assessed by Elemental analysis and metal estimation-neutral, monomeric nature of the complex and paramagnetic nature also predict by the conductance and magnetic moment study. The octahedral environment around Co(II) and metal-imine bond as a whole predicted by atomic IR and Far-IR spectra. In-vitro antibacterial and antifungal activities of the Schiff base and its complexes compared with those for standard (Chloramphenicol & Fluconazole) by agar disc diffusion method. The Ex-vivo antimalarial activity of the Schiff base and its metal complex was found by using Plasmodium falciparum bacteria/fungal.

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History

  • Receive Date: 26 December 2020
  • Revise Date: 12 February 2021
  • Accept Date: 18 April 2021

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