Effect of Glutamic Acid as Additional Monomer in Biodegradable Poly(xylitol Sebacate Glutamate) Polymer

Mohd Sani, Noor Faezah; Jafri, Nur Afiqah; Majid, Noor Aishatun; Rosaidi, Nor Alifah; Onn, Munirah

doi:10.21608/ejchem.2021.54273.3128

Effect of Glutamic Acid as Additional Monomer in Biodegradable Poly(xylitol Sebacate Glutamate) Polymer

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Tapah Road, 35400 Perak, Malaysia

² University Teknologi Mara Perlis Branch, Arau Campus, 02600 Perlis Malaysia

³ University Teknologi Mara Johor Branch, Pasir Gudang Campus, 81750 Masai, Johor Malaysia

10.21608/ejchem.2021.54273.3128

Abstract

Xylitol-based polyesters such as poly(xylitol sebacate) PXS are said to be the potential materials for tissue engineering due to their adjustable mechanical and degradation properties. However, the result indicated that the elastomers are very soft and have a low elongation at break. Therefore, to increase the mechanical strength and minimize the degradation rate, glutamic acid was added as the third monomer into the PXS. Novel Poly (xylitol Sebacate Glutamate) (PXSG) was successfully synthesized through melt polycondensation without using any harsh solvents and catalysts. The mixture was synthesized at 120°C for about 8 hours. Post polymerization process was carried out in the oven at 100 °C for three days to develop the crosslink network formation. Several testing and characterization were conducted to evaluate the effect of glutamic acid concentration in the polymer. From the result, FTIR spectroscopy confirmed the ester bond formation, tensile strength, and Young's modulus increased significantly while the percent of elongation at break and degradation rate decreased as the glutamic acid ratio increased.

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