Metformin considered as a drug that widely used in the treatment of diabetes type-2 patients, and it is recommended for management of hyperglycaemia as the first-line agent. This research included the preparation of new derivatives of metformin 1-8 which contain in their composition both cyclic imide and metformin components with expected anti-diabetic effects, via two methods, the first involved reacting metformin with different anhydrides (maleic, succinic, citraconic, phthalic, pyridinic, , pyromillitic) in the presence of glacial acetic acid as a solvent and dehydrating agent. The second involved smelting of metformin with equimolar amount of anhydrides (1,8-naphthalicanhydride and 1,4,6,8-naphthalicdianhydride).The compositions of the synthesized compounds 1-8 were confirmed using FT-IR spectroscopy, 1HNMR spectroscopy and elemental analysis (C, H, N, O), and the practical results were in agreement with the expected results.
Hamed, A. S., Ali, E. M., & Gayed, A. A. (2021). Synthesis and Characterization of New Derivatives Of Metformin with Expected Anti-diabetic Effects. Egyptian Journal of Chemistry, 64(6), 2973-2982. doi: 10.21608/ejchem.2021.55914.3194
MLA
Ahmed Solaiman Hamed; Ehab M. Ali; Asma Adil Gayed. "Synthesis and Characterization of New Derivatives Of Metformin with Expected Anti-diabetic Effects". Egyptian Journal of Chemistry, 64, 6, 2021, 2973-2982. doi: 10.21608/ejchem.2021.55914.3194
HARVARD
Hamed, A. S., Ali, E. M., Gayed, A. A. (2021). 'Synthesis and Characterization of New Derivatives Of Metformin with Expected Anti-diabetic Effects', Egyptian Journal of Chemistry, 64(6), pp. 2973-2982. doi: 10.21608/ejchem.2021.55914.3194
VANCOUVER
Hamed, A. S., Ali, E. M., Gayed, A. A. Synthesis and Characterization of New Derivatives Of Metformin with Expected Anti-diabetic Effects. Egyptian Journal of Chemistry, 2021; 64(6): 2973-2982. doi: 10.21608/ejchem.2021.55914.3194
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