Solvent-free synthesis of new chalcone derivatives from 3-nitro phthalic acid and evaluation of their biological activities

Document Type : Original Article

Authors

1 Department of Chemistry, College of Science, University of Baghdad Jadiriya, Baghdad, Iraq

2 Department of Pharmacy Al-Esraa University College, Baghdad, Iraq

Abstract

Synthesis of 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1, 3-dione chalcones were performed by fusion of 3-nitro phthalic anhydride with p-aminoacetophenone. Then the later was grinded with different aromatic aldehydes in the presence of sodium hydroxide to produce new chalcones derivatives A3-10 without using any solvent formation of new N-arylphthailimide chalcones were confirmed by FTIR,1HNMR, 13CNMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity some of them showed more biological activity than the standard drugs..

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History

  • Receive Date: 29 December 2020
  • Revise Date: 01 February 2021
  • Accept Date: 14 March 2021

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