Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacterial biological study

Alfahdawi, Aeed S.; Al-Sorchee, Sawsan M.; Saleh, Suhab E.; Saleh, Marwan M.

doi:10.21608/ejchem.2021.55277.3160

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacterial biological study

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Education for Women, University of Anbar, Ramadi, Anbar, Iraq

² Department of Biology, College of Education, Salahaddin University, Kurdistan Region, Iraq

³ Ministry of Education, Alanbar Administration, Iraq

⁴ College of Applied Sciences, University of Anbar, Iraq

10.21608/ejchem.2021.55277.3160

Abstract

In this research, the synthesis and biological activity evaluation of N, N`-(ethane-1,2-diyl)bis(1-phenyl methanimine) as Schiff base with Zinc (II) dithiocarbamate complex are successfully reported. The suggested geometry around zinc ion centre was determined using selected unique physicochemical and spectroscopic techniques. These include melting point, conductance, FTIR, UV-Vis, mass spectroscopy and 1H-NMR spectroscopy. The analytical as well as the spectroscopic characterization data proves the formation of zinc complex with general formula [Zn(L)]2 and the complex of this ion is adopting tetrahedral geometry about the metal centre. Furthermore, the present study was carried out to evaluate antibacterial activity of obtained Schiff base ligand and Zn complex against five strains of bacteria (Staphylococcus aureus, Escherichia coli, Lacto bacillus, Klebsiella Pneumonae,and Salmonella typhi). The results of antimicrobial screening suggest that Schiff bases can show a considerable activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Salmonella typhi while Zn-complex was reported to be more active against all bacterial strains which is used in this test. The antibacterial activity of each compound has been examined practically (in vivo) by treating burns rats infected with tested bacteria (Staphylococcus aureus and Salmonella typhi), the results have shown signs of good recovery at short time if it compared with antibiotic Ofloxacin (OFX) used at the same time. And the number of bacteria was reduced significantly (P ≤ 0.001) during the treatment days. Furthermore, the results showed that Zn-complex is effective in treating various skin conditions; it is preferable to use it in the treatment of pathological injuries and against other skin infections.

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