Detection Of Some Hormonal And Enzymatic Disorders Associated To Experimentally Iodine Induced Hyperthyroidism

Foda, Doaa S; Ibrahim, Noha  E

doi:10.21608/ejchem.2021.63609.3361

Detection Of Some Hormonal And Enzymatic Disorders Associated To Experimentally Iodine Induced Hyperthyroidism

Document Type : Original Article

Authors

Doaa S Foda ¹
Noha E Ibrahim ²

¹ Therapeutic Chemistry Department, Pharmaceutical Industries and Drug Research Division, National Research Centre, Dokki, Giza, Egypt.

² Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Giza, Egypt.

10.21608/ejchem.2021.63609.3361

Abstract

Aim: This study aimed to observe and report the status and the reaction of the body organs in case of administration of excess iodine.
Materials and methods: Mice were administrated intraperitoneally KI for forty days.
Results showed that the different organs respond to KI administration with different reactions. The thyroid gland expressed a gradual increase in serum thyroid hormones (T4&T3) which was accompanied with a detected significant decrease in serum TSH in addition to an observed histological changes in the thyroid tissue.
Liver was the most apparent organ that was affected by excess KI administration followed by the brain through expressing increasing significant T3 levels in tissues compared to control. On the other hand, the heart and the kidneys tissues displayed non significant decrease in T3 levels. The study evaluated some tissue specific enzymes which showed significant biochemical abnormalities in organs' functions.
Conclusion: Our data detected the features of a subclinical hyperthyroid case and express the initiation of an iodine induced hyperthyroidism pattern.

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