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(2011). Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines. Egyptian Journal of Chemistry, 54(5), 691-701. doi: 10.21608/ejchem.2011.1435
. "Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines". Egyptian Journal of Chemistry, 54, 5, 2011, 691-701. doi: 10.21608/ejchem.2011.1435
(2011). 'Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines', Egyptian Journal of Chemistry, 54(5), pp. 691-701. doi: 10.21608/ejchem.2011.1435
Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines. Egyptian Journal of Chemistry, 2011; 54(5): 691-701. doi: 10.21608/ejchem.2011.1435

Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines

Article 9, Volume 54, Issue 5, October 2012, Page 691-701  XML PDF (297.45 K)
DOI: 10.21608/ejchem.2011.1435
Receive Date: 27 November 2011,  Revise Date: 14 April 2012,  Accept Date: 15 April 2012 
Abstract
ASERIES of new 6,7,8,9-tetrahydrodibenz[ b,f][1,4]oxazepin-11(10H)-ones (3) was prepared by alkylation of salicylamides 1 with 2-chlorocyclohexanone followed by cyclodehydration of the resulting 2-cyclohexyloxybenzamides 2. New pyrido [2,3-b] [1,4]benzoxazepin-6(5H)-ones (8) were prepared by reacting salicoyl chlorides 4 or their corresponding acids 5 with 3-amino-2-chloropyridines 6 followed by treatment of the resulting amides 7 with sodium methoxide. Some of the new compounds were subjected to preliminary screened for their tranquilizing effect.
Keywords
Dibenz[b; f][1; 4]oxazepin-11(10H)-ones; Pyrido [2; 3-b] [1; 4] benz- oxazepin-6(5H)-ones; Tranquilizers and Diazepam
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