Design and Synthesis of New Curcuminoid Compounds and their Derivatives as Antioxidant Agents

Abood, Rehab; Alsalim, Tahseen Abdul Qader; Abood, Einas Abdul Aziz

doi:10.21608/ejchem.2021.49070.3005

Design and Synthesis of New Curcuminoid Compounds and their Derivatives as Antioxidant Agents

Document Type : Original Article

Authors

¹ Department of Chemistry, Education college for Pure Sciences, University of Basrah, Basrah, Iraq

² department of Chemistry, Faculty of Education for pure sciences, university of Basrah, Basrah, Iraq

³ Polymer Research Center, University of Basrah, Basrah, Iraq.

10.21608/ejchem.2021.49070.3005

Abstract

A series of new curcumin analogues and their derivatives were synthesized by reacting curcumin analogues with various substituted hydrazine compounds to afford new pyrazol derivatives. The preparation of ether and ester derivatives was also carried out. All synthesized compounds were characterized using FT-IR, 1HNMR, 13CNMR, and MS-ESI. The evaluations of these compounds have shown a good inhibition activity as antioxidant agents against the stable radical of diphenylpicrylhydrazyl (DPPH). Findings from this work demonstrated a high inhibition activity in compounds substituted with hydroxyl phenol groups in comparison with compounds with other groups.

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