Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones


3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with .......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.