Document Type : Original Article
Authors
1
Head of department of Phytochemistry and Plant Systematics,Division of Pharmaceutical Industries,National Research Center, El Buhouth st., Dokki Dokki, Cairo, Egypt
2
Chemistry Department, Faculty of Science, Zagazig University, Egypt.
Abstract
Phenolic profiling of edible parts Hyphaene thebaica ( Doum palm) are identified using LC-ESI-MS, the Overall polyphenolic constituents demonstrated by means of LC-ESI-Mass profiling . Twenty three isolated compounds were identified as ; caffeic acid, protocatechuic acid, rhamnetin, catechin, quercitrin, vanillic acid , kaempferol 3-O-acetyleglucoside , cinnamic acid, apigenin-7-O-glucose , intricatin 3-O-htyrosol, luteolin, quercetin ,naringenin , kaempferol ,vanillic acid 4-β-D-glycoside coumaric acid, ferulic acid, luteolin-6-arbinose-8-glucose, p-coumaroyl malic acid eriocitrin, apigenin and hesperetin
Iron nanoparticles (FeNps ) of H. thebaica fruit EtOAc extract was freshly prepared and characterized with Dynamic Light Scattering (DLS) with particles size 150.7 nm. The anti-proliferation activity of the crude extract of EtOAc and the synthesized Fe Nps was evaluated using MTT assay on human colon (Caco-2) and liver (HepG2) cancer cell lines.
The results declared that half maximal inhibitory concentration (IC50) of EtOAc extract on colon (IC50 35.4 µg/ml) and on liver cancer cell lines (IC50 72.02 µg/ml) while nanoparticles portion of EtOAc was found more pronounced on colon cancer cell lines (IC50 19.44 µg/ml) and on liver (IC50 15.5 µg/ml). So, the Fe Nps of EtOAc of H.thebaica fruit extract with particles size 150.7 nm is more effective as antitumor than the crude EtOAc extract.
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