Synthesis, Spectroscopic and Biological Characterization of Cr(III), Mn(II), Co(II), Ni(II) and Cu(II) Complexes with New Macrocyclic Tetradentate [N4] Schiff Base Ligands


THE SYNTHESES of three novel tetradentate Schiff base ligands, i.e. L1 = BBICI = benzo [1",2"-2,1] benzo [1"',2"'-8,7] indolo [3',2'-4,5] cyclododeca [10,11-b] indole, L2 = DBBICI = 4, 13 dimethylbenzo [1",2"-2,1]benzo [1"',2"'-8,7]indolo[3',2'-4,5] cyclo- dodeca[10,11-b]indole and L3=HHPPA= 10, 11, 12, 23, 24, 25-hexahydrophenanthro [9,10-a] phenanthro [9,10-h] [14] annulene and their novel complexes with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Cd(II) have been reported. The complexes are characterized by the elemental and thermal analyses, molar conductance and magnetic susceptibility ,1HNMR, IR and UV-Vis spectral also were studied. Cr(III), Mn(II), Co(II), Ni(II), Cd(II) and Cu(II) chloride and nitrate complexes have octahedral geometries while Cu(II) acetato complex has distorted octahedral leading to tetragonal geometry. The biological activities of the ligands and complexes have been screened in vitro against some bacteria and fungi to investigate their capacity to inhibit their growth.