Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate


ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate or formamide afforded -2- propylquinazolin-4(3H)-one (3). Behaviour of quinazolinone towards carbon electrophiles namely, aromatic aldehyde, chloroacetylchloride, and ethylchloroacetate has been investigated and all the synthesized compounds were tested as anti-cancer in National Cancer Institute (NCI) in USA.