THE CURRENT study describes the synthesis of Erythropoietin- ......which is a prohibited hormone by WADA-mimetic peptides [(AFIII54(chain I), (Ser)12AFIII54(chain II), AFIII54 with addition of Gly and Tyr in position 4 and 5, respectively (chain VI), AFIII54 devoid (Thr)9 and )Trp)10 (chain VII), (EMP3(chain III),(Ser)15EMP3 (chain IV), (Ala)15EMP3(chain V), EMP3 with addition of Gly and Tyr in position 7 and 8, respectively (chain VIII) and EMP3 devoid (Thr)12and (Trp)13(chain IX) ] by SPPS using microwave energy which accelerated reaction rate and improved the purities and yield.
Conformational analysis using FT-IR spectroscopy showed that most the synthesised peptides existed in α-helix structure . Also, biological activity for one of these sequences was studied.
(2010). Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy. Egyptian Journal of Chemistry, 53(3), 435-448. doi: 10.21608/ejchem.2010.1233
MLA
. "Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy", Egyptian Journal of Chemistry, 53, 3, 2010, 435-448. doi: 10.21608/ejchem.2010.1233
HARVARD
(2010). 'Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy', Egyptian Journal of Chemistry, 53(3), pp. 435-448. doi: 10.21608/ejchem.2010.1233
VANCOUVER
Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy. Egyptian Journal of Chemistry, 2010; 53(3): 435-448. doi: 10.21608/ejchem.2010.1233
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