(2016). Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles. Egyptian Journal of Chemistry, 59(3), 305-319. doi: 10.21608/ejchem.2016.1052
. "Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles". Egyptian Journal of Chemistry, 59, 3, 2016, 305-319. doi: 10.21608/ejchem.2016.1052
(2016). 'Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles', Egyptian Journal of Chemistry, 59(3), pp. 305-319. doi: 10.21608/ejchem.2016.1052
Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles. Egyptian Journal of Chemistry, 2016; 59(3): 305-319. doi: 10.21608/ejchem.2016.1052
Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles
Receive Date: 18 April 2016,
Revise Date: 11 June 2016,
Accept Date: 12 June 2016
Abstract
3 -AMINO-2- hydroxy-7-methyl- thiazolo[3,2-a]pyrimidin-5-one(5) ….was synthesized by one-pot reaction from 2-bromo cyanoacetamide, ethyl acetoacetate and thiourea. The new 3-amino-2-hydrazino derivatives (15,18), 2-pyrazol- thiazolo [3,2-a] pyrimidin -5-ones )14,17,20) and 2-(4-arylidene) -pyrazol-thiazolo [3,2-a] pyrimidin-5-ones (22a-d) were synthesized through facile condensing procedures starting from 3-amino-2-hydrazino-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (12). The newly synthesized products were characterized by their IR, ESI-MS, NMR and micro analytical data.
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