Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes

Document Type : Original Article

Authors

1 Department of Chemistry, College of Science, University of Bisha, Bisha, 67714 Kingdom of Saudi Arabia

2 Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

3 Department of Chemistry, Faculty of Science, Benha University, Benha 13518, Egypt

4 Department of Chemistry, Faculty of Science, Al Arish University, Al Arish, 45511 Egypt.

Abstract

Novel Pd(II), Ag(I), Pt(IV) and Hg(II) piroxicam (Pir) anti-inflammatory drug complexes were obtained upon the reaction of metal salts with piroxicam (Pir) in ethanol solvent at 60 °C. The proposed structure was explained with the aid of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-Vis.), magnetic calculations and thermogravimetric analyses (TG/TGA). The ratio of metal: Pir drug is found to be 1:2 in all complexes estimated by using molar ratio method. The conductance data reveal that Pd(II), Pt(II) and Hg(II) chelates are non-electrolytes except Ag(I) complex. The infrared spectrum of free piroxicam in comparison with its chelates indicated that the chelation mode occurs via the oxygen and nitrogen atoms of ν(C=O)carbonyl and ν(C=N)pyridyl, respectively. The kinetic parameters of thermogravimetric and its differential, such as activation energy, entropy of activation, enthalpy of activation, and Gibbs free energy were evaluated using Coats-Redfern and Horowitz-Metzger equations for Pir drug and its complexes. The antimicrobial tests were assessed toward some types of bacteria and fungi. The in-vitro cell cytotoxicity of the complexes in comparison with Pir against colon carcinoma (HCT-116) cell line was investigated

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History

  • Receive Date: 04 September 2019
  • Revise Date: 16 October 2019
  • Accept Date: 07 July 2020

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