Document Type : Original Article
Department of Chemistry, College of Science, University of Bisha, Bisha, 67714 Kingdom of Saudi Arabia
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
Department of Chemistry, Faculty of Science, Benha University, Benha 13518, Egypt
Department of Chemistry, Faculty of Science, Al Arish University, Al Arish, 45511 Egypt.
Novel Pd(II), Ag(I), Pt(IV) and Hg(II) piroxicam (Pir) anti-inflammatory drug complexes were obtained upon the reaction of metal salts with piroxicam (Pir) in ethanol solvent at 60 °C. The proposed structure was explained with the aid of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-Vis.), magnetic calculations and thermogravimetric analyses (TG/TGA). The ratio of metal: Pir drug is found to be 1:2 in all complexes estimated by using molar ratio method. The conductance data reveal that Pd(II), Pt(II) and Hg(II) chelates are non-electrolytes except Ag(I) complex. The infrared spectrum of free piroxicam in comparison with its chelates indicated that the chelation mode occurs via the oxygen and nitrogen atoms of ν(C=O)carbonyl and ν(C=N)pyridyl, respectively. The kinetic parameters of thermogravimetric and its differential, such as activation energy, entropy of activation, enthalpy of activation, and Gibbs free energy were evaluated using Coats-Redfern and Horowitz-Metzger equations for Pir drug and its complexes. The antimicrobial tests were assessed toward some types of bacteria and fungi. The in-vitro cell cytotoxicity of the complexes in comparison with Pir against colon carcinoma (HCT-116) cell line was investigated