Taurine's Role in Mitigating Radar-Induced Oxidative Stress and Reproductive Toxicity in Male Rats: Antioxidant Defense Mechanism, Biochemical and Physiological Study

Document Type : Original Article

Authors

1 Science and Technology Center of Excellence, Military production, Cairo, Egypt.

2 Chemistry department, Faculty of Science, Al-Azhar University, Cairo, Egypt.

Abstract

Abstract: This study investigates the protective effects of taurine against infertility induced by radar electromagnetic radiation (EMR) in male rats. Exposure to radar EMR led to a significant decrease in reproductive hormone levels (e.g., testosterone), sperm quality (motility and count), and a marked increase in oxidative stress markers and reactive oxygen species (ROS) production. Taurine supplementation attenuated these effects by restoring the activities of key antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)]. The research utilized 30 male albino rats divided into a control group, an EMR-exposed group, and a taurine-treated group. EMR exposure (2.5 GHz for 4 weeks) caused an approximately 40% decrease in testosterone levels and a 30% reduction in sperm motility. Taurine supplementation (2% in drinking water) effectively restored antioxidant enzyme levels to near-control values, reduced ROS production, and prevented testicular atrophy. The results underscore taurine's potential as a therapeutic agent to combat EMR-associated infertility, particularly in occupational settings with prevalent radar exposure. This study emphasizes the need for antioxidant interventions to protect reproductive health in high-EMR environments, aligning with broader research on taurine's role in mitigating oxidative stress in tissues of the liver, heart, and testes.

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