Document Type : Review Articles
Authors
1
organic and medicinal chemistry department, faculty of pharmacy, university of sadat city, menofia.
2
Professor of pharmaceutical chemistry , Faculty of Pharmacy, University of Ain Shams,cairo, Egypt
3
Pharmaceutical and Organic Chemistry Department, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
4
Associate professor at Pharmaceutical Chemistry Department, Faculty of pharmacy, Menoufia University, Shibin ElKom,
Abstract
This review provides a comprehensive overview of benzimidazoles, a crucial class of heterocyclic compounds in medicinal chemistry, and the significant impact of drug repurposing. We highlight the historical importance and diverse biological activities of benzimidazoles, emphasizing their therapeutic applications across multiple fields. The review also explores Structure-Activity Relationship (SAR) studies, illustrating how specific substitutions on the core dictate activity in various therapeutic areas, such as anti-inflammatory, antihypertensive, anthelmintic, anti-ulcer and anticancer agents. The review heavily emphasizes drug repurposing strategy, highlighting its key benefits, classification, examples and challenges. It thoroughly examines successful cases where benzimidazole-based drugs, such as mebendazole, flubendazole, albendazole, and pimozide, have found new applications, especially in cancer treatment, metabolic and infectious diseases management. While acknowledging the inherent challenges, the review stresses drug repurposing's substantial promise for meeting unaddressed medical demands by broadening the uses of existing medications.
Keywords
Main Subjects
)
View on SCiNiTO