To achieve high yields in chemical reactions, ensuring optimal conditions is crucial. This involves the complete use of starting materials and the absence of by-products. Aza-Michael reactions, particularly the additions of azoles to activated double bonds, significantly meet these criteria. The aza-Michael reaction plays a crucial role in the total synthesis of natural products and complex molecules, highlighting its practical utility in various industrial applications. Moreover, aza-Michael reaction is used to synthesize β-amino acids and β-amino ketones, which are valuable intermediates in the production of various biologically active compounds, including antibiotics and anticancer agents. It has been demonstrated that imidazole, its basicity plays a significant role with the reaction of crotonic acid leading to its quaternization with crotonic acid and the subsequent formation of imidazole cyanamate. For 1,2,4-triazole and benzotriazole, are attributed to the non-autocatalytic nature of the reactions and the reaction temperature.
Khachatryan, H., & Attaryan, H. (2025). BEHAVIOR OF IMIDAZOLE, 1,2,4-TRIAZOLE, AND BENZOTRIAZOLE IN AZA-MICHAEL REACTIONS WITH CROTONIC ACID. Egyptian Journal of Chemistry, (), -. doi: 10.21608/ejchem.2025.337812.10847
MLA
Hasmik Khachatryan; Hovhannes Attaryan. "BEHAVIOR OF IMIDAZOLE, 1,2,4-TRIAZOLE, AND BENZOTRIAZOLE IN AZA-MICHAEL REACTIONS WITH CROTONIC ACID", Egyptian Journal of Chemistry, , , 2025, -. doi: 10.21608/ejchem.2025.337812.10847
HARVARD
Khachatryan, H., Attaryan, H. (2025). 'BEHAVIOR OF IMIDAZOLE, 1,2,4-TRIAZOLE, AND BENZOTRIAZOLE IN AZA-MICHAEL REACTIONS WITH CROTONIC ACID', Egyptian Journal of Chemistry, (), pp. -. doi: 10.21608/ejchem.2025.337812.10847
VANCOUVER
Khachatryan, H., Attaryan, H. BEHAVIOR OF IMIDAZOLE, 1,2,4-TRIAZOLE, AND BENZOTRIAZOLE IN AZA-MICHAEL REACTIONS WITH CROTONIC ACID. Egyptian Journal of Chemistry, 2025; (): -. doi: 10.21608/ejchem.2025.337812.10847
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