Potential therapeutic effects of isolated polysaccharides from some edible plant wastes: Characterization and bioactivities

Document Type : Original Article

Authors

1 Pharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Centre.

2 Department of Pharmacognosy, National Research Centre

3 Deprtment of Therapeutic Chemistry , National Research Centre (NRC),El Behouth St. , P.O.12622. Dokki, Giza, Egypt.

4 Pharmacology Department, National Research Centre, Dokki, Giza, Egypt

5 prof. National Research Centre

Abstract

Polysaccharides have various effects and exhibit several bioactivities that possess an enormous influence on healthcare due to their therapeutic beneficial and comparatively low toxicity. The study is focusing in investigation of the chemical structure of the isolated polysaccharides from wastes of Punica granatum, Musa acuminate, and Brassica oleracea, beside to validation of the analgesic, anti-inflammatory, antipyretic and antiulcer activities. Moreover, the polysaccharide yields were determined, characterization of the hydrolyzates was performed using UV-visible, FT-IR, 1HNMR and GLC analyses. In addition, significant biological activities were obviously presented by all the isolated polysaccharides. The highest analgesic and anti-inflammatory activities exhibited by polysaccharides of B. oleracea outer leaves (62.98 and 81.69 %), followed by that of P. granatum peels (53.31 and 78.17%), and that of M. acuminate peels (50.50 and 76.05%), while the antipyretic activity was showed nearly the same results for both M. acuminate and B. oleracea polysaccharides (6.59 and 6.35%), then that of P. granatum peels (5.30%). On the other, the antiulcer activities of polysaccharides of different wastes showed corrective action of inflammatory markers including tumor necrosis factor -α (TNF-α), interleukin -6, 8 (IL-6 &8), myeloperoxidase (MPO) as well as lowering oxidative stress, improved lesion count which lead to ameliorations in histopathological picture of stomach. In conclusion, the polysaccharide isolated from Musa acuminate showed the most potent therapeutic effect in the majority of the biomarkers under investigation.

Keywords

Main Subjects


Volume 65, Issue 13 - Serial Number 13
Special Issue: Chemistry and Global Challenges
December 2022
  • Receive Date: 02 August 2022
  • Revise Date: 17 August 2022
  • Accept Date: 21 August 2022
  • First Publish Date: 21 August 2022