National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Effect of applying beetroot juice and functional vegetable oils in the preparation of high protein nutrition bars on its physicochemical, textural and sensorial properties11426107810.21608/ejchem.2022.156451.6773ENTarek NourSolimanDairy Department, Food Industries and Nutrition Division, National Research Centre, El-Buhouth st, Dokki, Cairo, Egypt0000-0002-1138-9133AhmedBehdalDairy Department, Food Industries and Nutrition Research Institute, National Research Centre, 12622 Dokki, Cairo, EgyptSaidFatouh HamedOil and Fats Dept, NRC0000-0001-5086-7110HamdyZahranFats and Oils Dept., Food Industries and Nutrition Research Institute, National Research Centre, Dokki, Cairo, Egypt0000-0003-2500-8378Journal Article20220815High protein nutrition bars (HPNBs) can be a convenient way to add proteins, carbohydrates, vitamins and minerals to the diet. Red palm super olein (RPSO), coconut oil (CO) and black seed oil (BSO) are unique sources of essential fatty acids, medium chain fatty acids as well as natural polyphenols, tocopherols and tocotrienols that play an important role in disease prevention and human body fitness. The protein bar was formulated with 36% Whey isolate and sodium caseinate protein, 33% glucose and sorbitol, and 13% RPO, CO, and BSO to create a protein bar rich in these natural oils. The freeze-dried beetroot juice powder was added at ratio of 1% of total formula. The prepared protein bars were characterized for texture profile (TP), cutting strength, water activity and sensory evaluation. The obtained results showed that the kind of applied protein affected the texture properties and physicochemical properties. The formulated HPNB bars using sodium caseinate showed the lowest TP and cutting tests. HPNBs prepared could be regarded as a very good natural supplement of essential fatty acids needed for human beings for protecting against many diseases. The bars showed also good sensory qualities because of the contribution of the functional coconut, red palm, and black seed oils, with their high contents of phenolic compounds, natural colorants and vitamin E that could increase the shelf-life of the product.https://ejchem.journals.ekb.eg/article_261078_f88d3c6417932d2f93031877faec64e8.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene152923713010.21608/ejchem.2022.136816.6032ENNehal Aly AhmedHamdyapplied organic chemistry , nrcHanemAwadTanning Materials and Leather Technology Department, National Research Centre, Egypt0000-0002-3970-2371Mohammad M.TarekBioinformatics Department, Armed Forces College of Medicine (AFCM) Cairo, EgyptHananMohamedApplied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt;Journal Article20220503Novel furan-2-one and pyrazole heterocycles incorporating 5,6,7,8-tetrahydronaphthalene moiety 4, 8, 10a-c, 12a-c and 13 were prepared starting from 2-acetyl tetralin via reaction with diethyl oxalate followed by cyclization using hydroxylamine hydrochloride, and hydrazine hydrate. Further treatment of carbohydrazide 8 with isatin derivatives 9a-c and hydrazonoyl halides 11a-c afforded N'-(5-subs.-2-oxoindolin-3-ylidene)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbohydrazides 10a-c and N'-aryl-2-(2-(3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbonyl)hydrazono)propanehydrazonoyl chlorides 12a-c. The novel compounds were examined in vitro for their anti-tumor activities against HepG-2 and MCF-7 human carcinoma cell lines using MTT assay. Most compounds showed good to moderate activities against HepG-2 carcinoma cells and HepG-2 cells.https://ejchem.journals.ekb.eg/article_237130_7146fc50f3788657a1d33402d7498f97.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Application of Thiourea Polyurethane@Copper Sulfide Composite for Antibacterial Potential313623749210.21608/ejchem.2022.125302.5573ENMohamed M.El-ZahedDepartment of Botany and Microbiology, Faculty of Science, Damietta University, New Damietta, Egypt0000-0003-2694-3720Hala A.KiwaanChemistry Department, Faculty of Science, Damietta University, EgyptAsmaa A.M.FarhatChemistry Department, Faculty of Science, Damietta University, EgyptElhossein A.MoawedChemistry Department, Faculty of Science, Damietta University, EgyptMervat A.El-SonbatiEnvironmental Sciences Department, Faculty of Science, Damietta University, Egypt0000-0003-4624-816XJournal Article20220304This work synthesized a new composite by coupling copper sulfide nanoparticles and isothiouronium polyurethane foam to enhance antimicrobial activity. Fourier transform infrared (FTIR), ultraviolet-visible spectra (UV/Vis), point zero charge (pHpzc), acidic and basic sites, iodine number, methylene blue value, energy disperse (EDX), X-ray diffraction (XRD), and scan electron microscopy (SEM) were used to characterize isothiouronium polyurethane@copper sulfide foam composite (ITPU@CuS). The antibacterial activity of ITPU@CuS was tested against Gram-positive (Bacillus cereus) and Gram-negative (Pseudomonas aeruginosa). The biocidal action of ITPU@CuS against the microbial strains was significantly higher at the concentration of 150 μg/ml than at lower concentrations. Also, transmission electron microscopy (TEM) of the ITPU@CuS-treated bacteria was studied. TEM micrographs of the treated bacteria confirmed the bactericidal action of ITPU@CuS by showing malformation action, wrinkling, and bacterial cell wall damage. The obtained composite could be considered to be a promising material aimed at industry, especially in the field of food packaging, where it is effective against pathogenic microbes.https://ejchem.journals.ekb.eg/article_237492_3b1d0ed17be84b57678a08a3858e5468.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Hydration Characteristics And Leaching Behavior of Different Mixes Of Slag Based – Geopolymer Cement In Presence Of Heavy Metals374823705310.21608/ejchem.2022.114795.5213ENDoaa AAhmedAin Shams University, Faculty of Women's, Chemistry DepartmentShereen M.RagaiChemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.SaraH. AbdallahChemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.0000-0002-8081-3110Journal Article20220105Geopolymer binders are now considered to be a necessary condition for replacing Portland cement (OPC) to improve environmental and durability efficiency. Heavy metal contamination has become a very dangerous environmental issue that is becoming increasingly over time. The purpose of this work is to examine the effect of some heavy metals on the hydration characteristic of different mixes of slag-based geopolymer pastes containing some waste materials such as fly ash (FA) and cement kiln dust (CKD), and also, to study the stabilization of heavy metals on the geopolymer matrix to measure the possibility of using this method to remove it. Geopolymer synthesis by 100% slag and partial substitution of slag by 15% FA (85% slag+15%FA) and 5% CKD replacement (95% slag+5% CKD) were investigated. The mixture of liquid sodium silicate (Na2SiO3) and sodium hydroxide (5M NaOH) with a ratio (1:1) is used as an alkaline activator solution. Various percentages of copper ions (Cu2+) or cadmium ions (Cd2+) are added to the alkali-activated mixes. The results indicated that best mix for immobilization of Cu2+ is 100 %slag + 0.5%CuCl2 and for Cd2+ were in case of 100% slag + 0.5%CdCl2 and 95% slag + 5% CKD +0.5%CdCl2. Our study results support the high immobilization of heavy metals in three differently prepared slag-based geopolymer pastes over 28 days and up to 90 days of hydration.https://ejchem.journals.ekb.eg/article_237053_c04b2380ab832cf26acc7d6855c116c5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and Characterization of CuO Nanoparticles For Increase The Efficiency of the photovoltaic cell495323534210.21608/ejchem.2022.115070.5227ENAliRasheedMedical Technical Insitute, Mansour, Middle Technical University, Baghdad, IraqAnfal IsmaelIbrahimAshur University College, Department of Dentistry, Baghdad, IraqSuraaReaadPharmaceutical Chemistry Dept, Pharmacy College, Al-Nahrain Univeristy, Baghdad, IraqMustafa M.KadhimDepartment of Dentistry, Al-kut College University, Kut, Wasit, IraqJournal Article20220108The green manufacture of CuO nanoparticles using Peppermint plant extract and calcination at 400 C for 60 minutes is described in this paper. The phase and structure of the CuO nanoparticles were investigated using XRD and SEM, respectively. The SEM scan indicated that the CuO nanoparticles were spherical, with a particle size average of 14-55 nm. The optical characteristics were studied using Spectroscopy in the UV-Visible range, plus the bandgap was calculated to be 2.7 eV. The DSSC characteristics such as voltage in the open circuit (Voc), The J-V curve was used to calculate the short circuit current density (Jsc), fill factor (FF), and efficiency (h)., and their values were Jsc =0.020 Acm2, Voc= 0.47 V, Jmax =0.009 Acm2 , Vmax =0.367 V, and FF = 0.351 . the conversion energy Efficiency is 3.3 %. It can be concluded that copper oxide Nanoparticles are good in synthesizing solar cells through energy production.https://ejchem.journals.ekb.eg/article_235342_e4405772ed1f18ec74df014e3c7f0a40.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis, studying analytical properties and biological activity of new transition metal complexes with sulfadiazine derivative as reagent556123589010.21608/ejchem.2022.104212.4814ENGhusoon JawadAbbasBranch of Biochemistry, Faculty of Medicine,Jabir ibn Hayyan Medical UniversityZaiedMosaaCollege of science for women, University of Babylon, Hilla, Iraq.Ali JabbarRadhiFaculty of Pharmacy, Al-Kafeel University, Najaf, Iraq.Hayder KadhimAbbasCollege of Pharmacy, University of Al-Kafeel, Najaf, Iraq.Walaa MohammedNajemCollege of Pharmacy, University of Al-Kafeel, Najaf, Iraq.Journal Article20211103A new of nickel(II) and copper(II) complexes of 4-((4-acetylphenyl)diazenyl)-3-amino-N-(pyrimidin-2-yl) benzenesulfonamide (SDA) derived from sulfadiazine have been prepared and identified by FTIR, NMR, mass spectroscopy, UV-Visible spectroscopy, and elemental analysis. Also tested to evaluated their activities as antibacterial agents. The spectroscopic and analytical data suggest all prepared nickel(II) and copper(II) complexes a square planar geometry. The agar well diffusion method was used to test the target ligand and their Ni(II) and Cu(II) complexes for antibacterial activity against Gram (+) and Gram (-) bacteria.https://ejchem.journals.ekb.eg/article_235890_7ccad10df2c55a6f6ea0fcdf6935c9d9.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Development of Novel Terpolymes and Evaluating Their Performance as Pour Point Depressants and Paraffin Inhibitors for Waxy Crude Oil637223063510.21608/ejchem.2022.120528.5414ENSameh A.ElbannaProcesses Development Department, Egyptian Petroleum Research Institute, Cairo, EgyptAbdellatief M. M.Abd El RhmanEgyptian Petroleum Research Institute, Nasr City, Cairo 11727, EgyptAyman S.Al-HussainiFaculty of Science, Port Said University, Port Said City, EgyptSalah A.KhalilEgyptian Petroleum Research Institute, Nasr City, Cairo 11727, EgyptJournal Article20220208In this work, novel styrene-based terpolymer styrene hexadecyl acrylate maleic anhydride was synthesized and modified via esterification and imidation reactions through the free radical polymerization technique. The synthesized terpolymers were characterized by FTIR, 1H-NMR, and GPC techniques. Also, their impact as pour point depressants and paraffin inhibitors for the Egyptian waxy crude oil were assessed using different concentrations (50-200 ppm). The results showed that all the synthesized additives have great impacts on depressing the pour point temperature and hindering the wax deposits formation. The best performance was achieved by injecting 200 ppm of styrene hexadecyl acrylate maleic anhydride imide which was able to depress the pour point from 27 °C to 9 °C and achieve a paraffin inhibition of 90%. Thus, the synthesized terpolymers can be considered as promising and applicable additives for depressing the pour point and inhibiting the paraffinic precipitates for the waxy crude oil.https://ejchem.journals.ekb.eg/article_230635_ea3b07616f3075bc613eb0c47e774724.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Computational Studies on the Thermodynamic and Kinetic Parameters of Unimolecular and Bimolecular Dissociation of Propylene Glycol Ethyl Ether in Binary 1-Butanol and Isobutanol Solvent Mixtures738023699610.21608/ejchem.2022.121471.5448ENRima H.Al OmariPharmacological and Diagnostic Research Center (PDRC), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan0000-0002-4661-656XKhaldun M.Al AzzamPharmacological and Diagnostic Research Center (PDRC), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan0000-0003-4097-6991Mansour H.AlmatarnehDepartment of Chemistry, University of Jordan, Amman 11942, Jordan.
Department of Chemistry, Memorial University, St. John’s, NL, A1B 3X7, CanadaAhmad A.AhmadDepartment of Applied Physics, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid-22110, Jordan.Asma M.GhazzyaPharmacological and Diagnostic Research Centre (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.Asmaa Y.AlnajajrahbDepartment of Chemistry, University of Jordan, Amman 11942, Jordan.Naeem M.ShalanPharmacological and Diagnostic Research Centre (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.Nida O.KaramehPharmacological and Diagnostic Research Centre (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.LyazzatBekbayevaAsfendiyarov Kazakh National Medical University, Department of Engineering disciplines, 88 Tole bi St., Almaty, Kazakhstan0000-0002-0804-1259El-Sayed MoussaNegimSchool of Petroleum Engineering, Satbayev University, 22 Satpayev Street, 050013 Almaty, Kazakhstan0000-0002-4370-8995Journal Article20220212This study includes a theoretical investigation of Thermodynamic and kinetics of the unimolecular and bimolecular dissociation reaction of Propylene Glycol Ethyl Ether in the gaseous phase. A B3LYP functional with 6-31G(d) basis set was used to optimize all geometries of the stationary points. Potential-energy surface for various channels for the reaction of PGEE was studied at APFD/6-31G(d) and ωB97XD/6-31G(d) levels of theory. The kinetic and thermodynamic parameters for nineteen reaction pathways are investigated. Most of the unimolecular dissociation mechanisms occur in a concerted transition state step endothermically. Our calculations proved that energy barriers for ethanol and acetone formation is the best reaction route with an activation barrier of 279 kJ mol-1 at APFD/6-31G(d) level of theory. The PGEE bimolecular reaction with 1-butanol, the pathway which produces H2 and butanal is more plausible to take place with a lower activation energy of 225 kJ mol-1 at ωB97XD/6-31G(d) level of theory.https://ejchem.journals.ekb.eg/article_236996_df9d2ba8278c0066ac89e28cf50c0fd1.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis, Characterization and Antibacterial Activity Studies of Cobalt(II), Nickel(II),Copper(II) and Zinc(II) Complexes with (3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide Ligand818823444810.21608/ejchem.2022.123881.5530ENMAHMOUD NajimAl-jibouriMustansiriyah University,College of Science, Chemistry Department of Chemistry, Baghdad-Iraq0000-0002-2346-417XHuda A.KareemHusseinMustansiriyah University,College of Science, Chemistry Department of Chemistry, Baghdad-Iraq0000-0002-2730-1030Najlaa QassimMuftinMustansiriyah University,College of Science, Chemistry Department of Chemistry, Baghdad-Iraq0000-0002-5892-6127Journal Article20220225A series of bi nuclear transition metal complexes of Co(II), Ni(II) ,Cu(II) and Zn(II) of the general composition (ML(H2O)2Cl2) where (M=Co(II), Ni(II) and Cu(II), L=(3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide). The new ligand was synthesized via ring closure of ((E)-1-(4-bromophenyl)-3-(thiophen-2-yl)prop-2-en-1-one) with the excess of thiosemicarbazide. The new 2-pyrazoline was identified by MS, NMR,FT-IR spectra in addition the elemental microanalyses were carried out to elucidate the chemical structure after adjusting the thin-layer chromatography in (3:1) volume ratios of eluent solvents of ethylacetate and chloroform. The solid metal complexes of the new ligand were prepared and isolated in their solid state by direct reactions of their metal chlorides with the ethanolic solution of the ligand (L). The new metal complexes of cobalt(II),nickel(II),copper(II) and zinc(II) were fully characterized by elemental analysis (C.H.N.S), FT-IR, molar conductivity measurements in DMF solvent, electronic spectra and magnetic susceptibility via Farady’s method. As well as the ionization mass spectra was assigned for some complexes to investigate the expected skeletal of the complexes. The data observed from elemental analyses, flame atomic absorption and spectroscopic techniques afforded the octahedral environment around cobalt(II),nickel(II) and copper(II) ions whereas the tetrahedral geometry was adopted for ZnLCl2.The anti-microbial activities of these derivatives have been studied by screening them against bacteria like Staphylococcus aureus and Eschericheia Coli and fungi like Aspergillusnidulece and Condida albicance by Serial dilution method.https://ejchem.journals.ekb.eg/article_234448_416cd6e64ae1eef15859f18d8f7fa55d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Larvicidal And Repellent Potential Of Patchouli Extract (Pogostemon Cablin) Varieties Of Southeast Sulawesi For Aedes Aegypti Vector899823063110.21608/ejchem.2022.123730.5527ENReniYunusDepartment of Medical Laboratory Technology0000-0001-5251-5485SupiatiSupiatiDepartment of Medical Laboratory TechnologySuwarniSuwarniHealth Polytechnic of KendariIda MardhiyahAfriniFaculty of Medicine, Universitas Halu Oleo, Kendari, Southeast Sulawesi, Indonesia,MubarakMubarakFaculty of Medicine, Universitas Halu Oleo, Kendari, Southeast Sulawesi, Indonesia,0000-0001-9053-2761Journal Article20220224The development of resistance to chemical insecticides has become a problem in vector control. This demands the need for research and development of environmentally friendly methods for vector control of Aedes aegypti. The efficacy of Pogostemon cablin extract as a repellent for adult mosquitoes is an alternative. Repellent can reduce exposure to mosquito bites that may be infected with the dengue virus. To conduct phytochemical testing and content analysis of essential oil of Patchouli (Pogostemon cablin) varieties of Southeast Sulawesi. Research samples were the leaves and stems of the patchouli plant (Pogostemon cablin) of the Southeast Sulawesi variety. This research uses the Harbone method of phytochemical testing and essential oil distillation. The results of the phytochemical test of patchouli leaves (Pogostemon cablin) of Southeast Sulawesi varieties were alkaloids, flavonoids, triterpenoids, polyphenols and terpenoids, while patchouli stems contained alkaloids, triterpenoids, tannins, polyphenols and terpenoids. The test results for the essential oil content of the patchouli leaves identified eugenol, patchouli alcohol, linalool and a-pinene. The leaves and stems of patchouli plant have potential as larvicides and repellents for the vector of Dengue Hemorrhagic Fever, Aedes aegypti.https://ejchem.journals.ekb.eg/article_230631_a66f0a3e33845f05094268fd2a66300e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Rhizobacterial Culture Supernatant As A Promising Strategy For Banana Tissue Culture Improvement9911223019910.21608/ejchem.2022.113172.5226ENHebaAmenDepartment of Microbiology, Faculty of Agriculture, Cairo University, Giza 12613, EgyptRania A.TahaPomology Department, Biotechnology and Micropropagation Lab, Agriculture and Biological division, and Tissue Culture Technique Lab, Central Laboratories Network, National Research Centre, Giza, Egypt0000-0003-1163-0406Mohamed A.MoselhyMicrobiology Department, Faculty of Agriculture, Cairo University, 12613 Giza, EgyptMichael R.GoharDepartment of Microbiology, Faculty of Agriculture, Cairo University, Giza 12613, EgyptMohamedAbdelalimDepartment of Microbiology, Faculty of Agriculture, Cairo UniversityTarekElsayedDepartment of Microbiology, Faculty of Agriculture - Cairo UniversityJournal Article20220108Tissue culture propagation of Banana (Musa spp.) proved to be the alternative commercial tool for traditional vegetative propagation through suckers. The aim of this study was to explore the application of bacterial culture supernatant as a substitution for commercial indole acetic acid (IAA) for improving plant tissue culture production. <br /><br />Up to 200 bacterial isolates were obtained from different banana plant spheres (rhizosphere, endorhiza, and stem-endosphere) and screened for their in vitro ability to produce IAA. About 50% of isolates were able to produce IAA with different amounts; the most promising IAA producing isolates were further identified according to the 16S rRNA gene sequencing. The chemical composition of the culture supernatants of most promising IAA producing isolate; Brevibacillus brevis-R39 and Klebsiella variicola-R19 were determined using GC-MS analysis, then the culture supernatants of Brevibacillus brevis-R39 was selected as Murashige and Skoog (MS) medium supplement at different doses (5, 10, 20, and 40 ml/l), corresponding to 0.21, 0.42, 0.4, and 1.68 mg IAA/l, respectively) in comparison to commercial IAA (0.5, 1, 2, and 4 mg/l). The results demonstrated that the culture supernatant of Brevibacillus brevis-R39 at 10 ml/l significantly showed the highest average length of banana shoots (11.9% over the control), followed by its 5ml/l (7.8% over the control). The greatest width of leaves (24% over the control) was recorded with the bacterial extract at concentration of 5 ml/l, followed by 13.2% over the control with bacterial extract at 10 ml/l. The greatest length of roots (49% over the control) was recorded with the bacterial extract at 10 mg/l, followed by 22% over the control with IAA at 2 mg/l. Our results recommend the use of Brevibacillus brevis-R39 culture supernatant as a medium supplement as a substitution for commercial IAA to improve banana plantlet properties.https://ejchem.journals.ekb.eg/article_230199_1e6fde60e5927a1d1dec14cff1f93707.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives11312023063710.21608/ejchem.2022.114873.5214ENMahmoud Nabil MahmoudYousifDepartment of Photochemistry, National Research Centre, Cairo, EgyptReda M.AbdelhameedDepartment of Applied Organic Chemistry, Chemical Industries Research Institute, National Research Centre, EgyptAmeen AAbu-HashemPhotochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, EgyptNabil M.YousifPhotochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, EgyptJournal Article20220105Chromene derivative 1 reacted with acetyl chloride and chloroacetyl chloride to give compounds 2a,b. Acetyl derivatives 2a,b were heated under reflux in dry xylene to give oxazine derivatives 3a,b which reacted with hydrazine hydrate and hydroxylamine to afford compounds 4a,b and 5a,b respectively. Pyrimidine derivative 4a reacted with xylose and glucose to give compounds 6a,b which were converted to compounds 7a,b by reaction with acetic anhydride. The structure of the prepared derivatives was elucidated through mass spectroscopy, 1H & 13C NMR, infrared spectroscopy and elemental analysis. Anticancer activity of some of prepared compounds was performed against three different cancer cell lines.https://ejchem.journals.ekb.eg/article_230637_d8eabe8711e0e908ee41d9209bc05067.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101The Impact of Spraying Selenium, Glutamic Acid and Seaweed Extract on Growth, Productivity, Physical and Chemical Fruit Properties of Banana12112822946510.21608/ejchem.2022.123837.5529ENRamadan AhmedEisaHort. Tech. Crop Dept., Agriculture and Biological Institute, National Research Centre, Cairo, EgyptMohamed AminMerwadPomology Depart., Agriculture and Biological Institute, National Research Centre, Cairo, EgyptEsam Ahmed MohamedMostafaPomology Department, Agriculture and Biological Institute, National Research Centre, Cairo, Egypt0000-0002-0667-8723Mohamed Maher SaadSalehPomology Department, Agriculture and Biological Institute, National Research Centre, Cairo, EgyptNagah NoemanyAshourPomology Department, Agriculture and Biological Institute, National Research Centre, Cairo, Egypt0000-0003-0586-1603Journal Article20220225This work was conducted through two successive seasons (2018 and 2019) on Grand Nain banana grown in a private orchard located at El-Kalubia Governorate, Egypt to evaluate seaweed extract, selenium and glutamic acid effects on vegetative growth, yield as well as physical and chemical properties of the fruits. Plants were sprayed four times (mid of April, May, June and July) with glutamic acid at 50 or 100 ppm, seaweed extract at 0.05 or 0.1% and selenium at 50 or 100 ppm, as a single or combined applications. Treatments were very effective in stimulating all vegetative growth, bunch weight as well as physical and chemical fruit properties comparing with to the control treatment. A superior effect was obtained with the foliar spray of seaweed extract, followed by glutamic acid and selenium. Spraying banana plants four times with a mixture containing glutamic at 100 ppm + seaweed extract at 0.1%+ or selenium at 100 ppm recorded the best results with reference to vegetative growth, bunch weight and fruit properties.https://ejchem.journals.ekb.eg/article_229465_5eb95ada501a2bef9859ffafe0045027.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Biochemical and histopathological studies of the anti-hyperglycemic and anti-hyperlipidemic effects of some extracts of aerial flowering parts of Onopordum alexandrinum Boiss. in alloxan-induced diabetic rats12914223548310.21608/ejchem.2022.126845.5640ENNashaatMahmoudBotany and Microbiology Department, Science, Al-Azhar University, Cairo, EgyptAbdelmonemSharafBotany and Microbiology departmentDrmayadaElazabMedicinal and Aromatic Plants Department,Desert Research Center, Cairo,EgyptElhawElhawBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, EgyptJournal Article20220312Diabetes mellitus (DM) is a metabolic abnormality linked to a higher risk of heart disease and stroke. The objective of this research is to see how three extracts of Onopordum alexandrinum Boiss affect serum glucose and blood lipids in diabetic rats that have been given alloxan. For 21 days, 48 mature male Sprague-Dawely albino rats (125-135 g) were chosen at random and placed into six groups of eight animals each: (1) non-diabetic control group, (2) diabetic control group, (3) diabetic group + Glibenclamide (10 mg/kg body weight), (4) diabetic group + petroleum ether extract of O. alexandrinum (480 mg/kg body weight), (5) diabetic group + ethyl acetate extract of O. alexandrinum (420 mg/kg body weight), and (6) diabetic group + ethanol (70%) extract of O. alexandrinum (600 mg/kg body weight). Triglycerides(TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein (VLDL) and glucose levels were measured in the serum of all individuals at 0, 3, 7, 14, and 21 days. In comparison to the control group and diabetic control group, administration of 480, 420, and 600 mg/kg body weight of petroleum ether, ethyl acetate, and 70 % ethanol O. alexandrinum extracts resulted in significantly lower glucose, TC, TG, LDL-C, VLDL levels, and increased HDL levels (p<0.05). Histological evaluation of groups treated with different O. alexandrinum plant extracts revealed that the injured pancreas was reconstructed. These findings suggest that O. alexandrinum extracts had a substantial influence on blood lipids and glucose levels in diabetic rats at all doses, suggesting that they could be effective in preventing and treating diabetes.https://ejchem.journals.ekb.eg/article_235483_70eae9f894831f6a25c8ac8446a37596.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Altered Electrochemistry of Tropium Chloride on A Multiwalled Carbon Nanoelectrode: Rapid and Selective Detection in Authentic, Pharmaceutical and Biological Fluids by Square Wave Cathode Voltammetry.14315422961110.21608/ejchem.2022.120139.5396ENHassanHendawyNational Organization of Drug Control and Research, Cairo, (Egypt).0000-0003-4971-1041Alaa SAminchemistry, science, Banha university0000-0002-5616-435XMostafa YNassarChemistry Department, Faculty of Science, Benha University, Egypt0000-0002-5177-9777AhmedKhalialChemistry Department
Faculty of scienceJournal Article20220205The voltammetric behavior of Trospium chloride (TRC) was studied using Cyclic (CV) and square wave (SWV) voltammetry. CV showed only one well-defined, irreversible, diffusion-controlled reduction peak using 0.04M Britton-Robinson buffer, PH 8.0 at modified with Mullet wall carbon Nano tube electrode (MWCEP). The peak current concentration relationship was rectilinear a much wider linear dynamic range of TRC determination was found over the range 0.3-2.6 μg/ml at MWCEP, with a minimum detectability of 0.07 μg/ml based on S/N = 3. And hence CV and SWV were conducted for the quantitative determination of (TRO) in its pure and pharmaceutical dosage form. The method was validated and the results were in good agreement with those obtained from the reported method. The Fabricated MWCEP exhibited many outstanding characteristics such as good stability, highly sensitivity, and notable repeatability. The designated sensor was used to determine TRC in biological fluid samples with good recovery. The proposed method was successfully applied for the estimation of TRC drugs in its combined dosage form and in human serum.https://ejchem.journals.ekb.eg/article_229611_2d0b85dad55407812d629c79352b9f42.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Storability and Fruit Properties of Hass Avocado as Affected by Moringa Seed Oil, Algae Extract and Arabic Gum Postharvest Treatments15516823732510.21608/ejchem.2022.134816.5933ENEman, A.A.Abdel MoniemHorticulture Crops Technology Department, Agricultural and Biological Institute, National Research Centre, Dokki, Cairo, Egypt0000-0003-2737-4398Rasha, S.Abdel-HakPomology Department, Agricultural and Biological Institute, National Research Centre (NRC), Dokki, Cairo, Egypt0000-0001-7995-2845Aml, R.M.YousefHorticulture Crops Technology Department, Agricultural and Biological Institute, National Research Centre, Dokki, Cairo, Egypt0000-0002-4062-9175SalehM.M.S.Pomology Department, Agricultural and Biological Institute, National Research Centre (NRC), Dokki, Cairo, Egypt0000-0002-2978-190XSafaa, R.El-lethyBotany Department, Agricultural and Biological Institute, National Research Centre, Dokki, Cairo, EgyptJournal Article20220419This research was carried out over an average of two successive seasons (2020 and 2021), at postharvest laboratory. The experiment aimed to investigate the effectiveness of using seed oil of three Moringa species [(peregrina Forssk. Ex, stenopetala (Baker f.), oleifera Lam.)] and algae extract each at 1000 ppm combined with Arabic gum at two concentrations (5% and 10%) as a natural ecofriendly products in parallel with untreated fruits as a control on quality and storability of Hass avocado fruits under cold storage conditions (5°C and 85 - 90% RH). The acquired results displayed that, all implementing parameters were affected affirmatively by different utilized treatments. However, it’s obvious that, Moringa oleifera seed oil at 1000 ppm+ 10% Arabic gum treatment was the most effective one and gave positive results concerning fruit firmness, titratable acidity and the activity of polyphenol oxidase (PPO) and improved total phenol, chlorophyll a, b and carotenoids. On the other hand, fruit weight loss, titratable acidity and PPO activity were excessed; however, fruit firmness, TSS, ascorbic acid, total phenol, carbohydrates and carotenoids values were relatively decreased due to the untreated fruits (control).https://ejchem.journals.ekb.eg/article_237325_50b8137ecd866878a5d1099972c7afe2.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Heterocyclization of Thiourea Derivative to Novel Azines and Azoles: Antioxidant and Antimicrobial studies16917423102010.21608/ejchem.2022.132131.5814ENMohamedAbd El-AzimDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt.Mohammed GommaAssyDepartment of Chemistry, Faculty of Science, Zagazig University, (Egypt)WaelFaridDepartment of chemistry, faculty of science, Zagazig universityAtefAbdelhamidDepartment of chemistry, faculty of science, Zagazig university, EgyptJournal Article20220407N,N'-disubstituted thiourea derivative 2 underwent oxidative cyclization with Br2/AcOH mixture to give thiazole 3.Thiadiazole 6 was obtained as the result of chlorination of 2 followed by amination and subsequent intramolecular cyclodehydraration. Thermal treatment of N,N'-disubstituted thiourea derivative 2 with TEA in DMF resulted in hydrolysis of 2 to furnish thiourea derivative 8. Treatment of compound 8 with semicarbazide, thiosemicarbazide, diethyl succinate, diethyl malonate / benzaldehyde or urea resulted in the formation of triazoles 11a,b, pyrrole 13, thiazine 16 and oxathiazole 19. The newly synthesized compounds were tested for their antioxidant and antimicrobial activities.https://ejchem.journals.ekb.eg/article_231020_2815029c675f59d565ac2c6b21a9d70c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101New Derivatives from 4-Amino Anti-Pyrine and Vanillin, Synthesis Characterization and Antibacterial Activity17518123525710.21608/ejchem.2022.135727.5977ENHawraa MAlabidiDepartment of Chemistry, Faculty of Science, University of Kufa, IraqAli MFarhanMinistry of Education, Al-Najaf, IraqHutham Mahmood YousifAl-labbanDepartment of Chemistry, Faculty of Science, University of Kufa, IraqAhmed Abduljabbar JaloobAljanabyDepartment of Biology, Faculty of Science, University of Kufa, Iraqhttp://orcid.org/000Journal Article20220424Schiff base, Azo-Schiff base, nickel (II), and copper (II) complexes have been prepared successfully from 4-amino antipyrine and vanillin and diagnosed by UV-visible, FT-IR, 1H-NMR, and 13C-NMR. The derivative compound Azo-Schiff with a 200 mg/ml concentration has good antibacterial activity with a diameter of inhibition zone 16.11 ± 0.1035 mm and 13.21 ± 0.4044 against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), respectively. Therefore, this compound may be considered a raw material for manufacturing treatments against these bacterial infections.https://ejchem.journals.ekb.eg/article_235257_11b7812aa82ca9837600654bcb5e37ed.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Chemical and Green Silver Nanoparticles: Synthesizing, Characterizing, and Antimicrobial Activity Against Microorganisms in Hatchery Plants18319423542410.21608/ejchem.2022.133474.5893ENNagwa H.HamoudaDepartment of Microbiology, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt0000-0003-1415-9533Hanan FaroukYoussefCeramics, Refractories and Building Materials Department, National Research Centre (NRC), Dokki, 12622, Giza, Egypt.0000-0002-1032-8312Waleed D.SalehDepartment of Microbiology, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.M. I.El SabryDepartment of Animal Production, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.Nasr F.NasrDepartment of Microbiology, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.0000-0001-6823-2244Journal Article20220414This work compares the characteristics and antimicrobial activity of chemically- and green-synthesized silver nanoparticles (Ag-NPs). The Ag-NPs were characterized using UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR) analyses, Transmission electron microscopy (TEM), and Zeta Potential (ZP). Results revealed that chemically synthesized Ag-NPs (C-Ag-NPs) were spherical with a particle size range of 4.86 to 13.6 nm, while the green-synthesized Ag-NPs (G-Ag-NPs) were of multi-shapes and size- range of 38.9 to 103 nm. Zone-inhibition test was done to compare the antimicrobial activity of both versions against common microbes of hatchery machines such as: G+ bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant Staph. aureus (MRSA), G- bacteria (Escherichia coli O157; Pseudomonas aeruginosa, and Salmonella typhimurium), Mold (Aspergillus niger) and yeast (Candida albicans). Generally, both C-Ag-NPs and G-Ag-NPs had significant effects on the tested microbes. The antibacterial effect of G-Ag-NPs against Ps. aeruginosa, B. cereus, and MRSA was significantly stronger than that of C-Ag-NPs, while the antifungal effect of C-Ag-NPs against Aspergillus niger was superior over that of G-Ag-NPs. For application, G-Ag-NPs and TH4 (a commercial disinfectant of poultry facilities) were separately sprayed onto the wall of egg incubators to compare their effect on total aerobic counts, total spore counts and total fungi. Results showed that both G-Ag-NPs and TH4 had strong effects on total aerobic counts, total spore-counts, and total fungi. G-Ag-NPs indicated higher efficacy than TH4. It could be concluded that G-Ag-NPs may be a promising antimicrobial candidate for sanitizing poultry facilities.https://ejchem.journals.ekb.eg/article_235424_fcd4a692a36eb4cd350ecb3f20654c34.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Effect of hydroxychloroquine and Artemisia herba-alba administration on liver enzymes and kidney functions in laboratory male mice19520423475710.21608/ejchem.2022.133057.5890ENReam AbbasAbed AldrajiDepartment of Biology, College of Science, University of Misan, Maysan, IraqZainabAbdul Jabbar Ridha Al-AliDepartment of Biology, College of Science, University of Misan, Maysan, IraqJournal Article20220414Objective: study the effect of hydroxychloroquine (HCQ) and Artemisia extract on liver enzymes and kidney function tests.<br /><br />Methods: seventy-two male mice are used in Lab as equal four groups: <br /><br />- A control group diagnosed with distilled water,<br /><br />- 1st group diagnosed with hydroxychloroquine (HCQ)<br /><br />- 2nd group diagnosed with hydroxychloroquine and Artemisia extract<br /><br />- 3rd group was diagnosed with Artemisia extract. <br /><br />The time of investigation was around 6-18 days for each group of mice orally.<br /><br />Results: AST, ALT, and ALP as liver enzymes increased in 1st and 2nd groups but these enzymes were low at 3rd group. Urea level increased in 1st group and decreased in 2nd group while no change was noticed in 3rd group. Also, Creatinine levels showed no significant change in all groups in comparison with the control group. After 6,12and 18 days of oral administration, the liver enzymes increased specially in 1st and 2nd groups. Also, urea concentration increased after 6, 12 and18days in 1st group. While, Creatinine levels showed no significant change in all periods. <br /><br />Conclusion: Treatment of mice body at our lab with HCQ, Artemisia extract or both led to increment of liver enzymes, while urea level in mice body was high as we treated with HCQ and with low level in both HCQ and Artemisia extract.https://ejchem.journals.ekb.eg/article_234757_7ad28b3802b7e3d0a849f527f876796a.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Impact of feeding ration supplemented with silymarin-rich extract on milk quality of goat and utilization of milk in producing functional soft-cheese20521523723810.21608/ejchem.2022.132914.5871ENSameh M.ShedeedDairy Technology Department, Animal Production Research Institute, Agriculture Research Center, Dokki, Cairo, Egypt0000-0001-9573-0273Eman H.ElSabaawyAnimal Production Department, Agricultural and Biological Research Institute, National Research Centre, Dokki, Cairo, EgyptMamdouh IMohamedAnimal Production Department, Agricultural and Biological Research Institute, National Research Centre, Dokki, Cairo, EgyptHoda BMabrokNutrition and Food Science Department, Food Industries and Nutrition Research Institute, National Research Centre, Dokki, Cairo, Egypt0000-0002-3839-0062Walaa M.Abd El-WahabAnimal Nutrition Department, Animal Production Research Institute, Agriculture Research Center, Dokki, Cairo, EgyptJournal Article20220414Silymarin is a flavonoid complex extracted from the milk thistle plant and acts as a strong antioxidant. Using natural compounds as additives in livestock nutrition could be a new goal in livestock production. The objective of this study was to investigate the effect of a ration containing different levels of silymarin-rich extract (10, 20, or 30 g) on fatty acids profile, production and quality of goat milk; and producing functional cheese from milk. Egyptian Nubian pregnant goats (n=16) were divided into four groups. Group 1 fed on a control ration. Groups 2, 3, and 4 were fed on a control ration and orally administrated with different levels of silymarin-rich extract at 10, 20 or 30 g/day, respectively. The feeding experiment lasted 4 months. The results showed that silymarin-rich extracts improved milk composition and quality by increasing protein and fat concentrations. Milk yield was significantly increased by silymarin-rich extracts supplementation. Feeding goats on rations supplemented with silymarin-rich extracts altered nutritional value of milk by increasing unsaturated fatty acids and decreasing the saturated fatty acids levels. Cheese produced from goat milk showed a high content of fat and protein. Sodium dodecil sulphate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of cheese-protein showed that adding the silymarin-rich extract to the goat feed increases the protein level in particularly β-casein, αs1-casein and αs2-casein. It could be concluded that using silymarin-rich extracts in rations of goats improved milk production, milk quality, and milk fatty acids. Silymarin-rich extracts improved the quality of goat cheese.https://ejchem.journals.ekb.eg/article_237238_605b9f2e0ac039dde79422d7011159ef.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Anticancer Study of Innovative Macrocyclic Formazan Compounds from Trimethoprim Drug21723023226910.21608/ejchem.2022.132514.5852ENNagham MahmoodAljamaliProfessor, Department of chemistry, Organic Synthetic Chemistry , Iraq.Zainab MohamedFarhanM.Sc -Student ,Part of Thesis ,Chemistry Department, College of Education for Girls, Iraq.Journal Article20220409Innovative Macrocyclic Formazan Compounds were generated and advanced globally for the first time by researcher (Prof. Dr. Nagham Aljamali in April 2019) via more than five steps of reaction with various catalyst like (tri ethyl amine, pipyridine ,…)., Therefore, these compounds considered one of the developed and modern compounds in organic chemistry., These biochemical Compounds were synthesized via many steps of reaction with various catalytic agent such as {(CH3)3N , pi.pyridine ,…}., Hence, these compounds deliberated one of the industrialized and modern compounds which have absence of literatures and researches which clue us to prepare and create a chain of these Modernized compounds and studied by abundant uses in future literatures represented by biological, pharmaceutical , nano , antimicrobial studies, also as anticancer agents, and here in this research. A numeral of applied identical studies have been used to revel their structures which delivered to strong indications of their structures through different methodical routes like Spectra Depiction., other studies represented by physical with chemical belongings., and anticancer study for biochemical compounds through (MTT)-Method was used to conclude cell viability by chromatic inspection (64-70) of types (MCF-7 and MCF- 10 A lines) for compounds [ 9 , 10].https://ejchem.journals.ekb.eg/article_232269_008eec6b438efc290cf7248d3b43a0e0.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Comparison of some parameters in urinary tract infection disease patients according to leukocytes count, bacterial type and C-reactive protein in Al- Najaf governorate23123723084310.21608/ejchem.2022.132277.5829ENHasan HadiAliJabir ibn Hayyan Medical University/ Presidency University, IraqArshad Noori GhaniAL- DujailiDepartment of Biology, Faculty of Sciences, University of Kufa, IraqJournal Article20220408This study focuses on using three biomarkers; leukocytes count, bacterial type and C-reactive protein as prognostic indicators for urinary tract infection. Sixty Patients between November 2021 and January 2022 in AL-Najaf province (AL-Sader medical city and private laboratories) were included in the study. The results indicated a significant increase in these biomarkers in UTI patients, when compared to the control group. Also, a significant increase in all biomarkers according to bacterial infection especially in E. coli infected patients as compared with Staphylococcus aureus patients and Klebsiella sp. Patients.https://ejchem.journals.ekb.eg/article_230843_ee44554d2d19e056b5964367068b61ea.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Heterocyclization of Poly functionalized Pyrimidine: Novel Synthesis and Antiproliferative Evaluation of Azino and Azolo Pyrimidines23924822881110.21608/ejchem.2022.130304.5741ENMohamed HAbd El-AzimDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt.MohamedAssyChemistry Department, Faculty of Science, Zagazig University, ET-44519, Zagazig,, EgyptRehamGalalZagazig University, Faculty of ScienceYasserSelimChemistry Department, Faculty of Specific Education. Zagazig University0000-0002-5846-9069Journal Article20220329Mercaptopyrimidin 1 was subjected to an acidic medium reaction with urea and aromatic aldehydes, yielding pyrimidopyrimidine 5a,b via unsaturated system 3, followed by 1,4 additions and subsequent H2S elimination. Using thiourea and/or guanidine instead of urea in the aforementioned process yielded pyrimidines of type (5 c-f). Condensation of benzaldehyde and its derivatives with compound 1 is followed by H-shift and oxidative cyclization, resulting in polycyclic compounds. 7. To make ozoloazines 9a-b, compound 7 undergoes a substitution reaction with urea and thiourea, followed by air oxidation. The cyclocondensation of hydrazides derivatives yielded triazolopyrimidines (12 a, b). In vitro, all novel pyrimidine derivatives were tested for antiproliferative activity against two cell lines: human gastric carcinoma (BGC-823) and human lung cancer (A-549). The results were compared to the NIH/3T3 murine fibroblast cell line. Some of these compounds, in particular 5a–f, 6,8,10a-b and 12a-b, were discovered to be the most effective derivatives against all cancer cell lines, with no impact on normal cells. Using the structure–activity connection as a guide, compound 10b has a greater activity against A-549 cells (IC50= 14.15 0.33 g/ml), as it contains thiadiazolidine imine nucleus which attached to thio pyran ring.https://ejchem.journals.ekb.eg/article_228811_f30ee0d2be89bb05f60b839eb14c45d8.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101HPLC-PDA-ESI-MS-MS Analysis of Acids Content of Lantana camara L. Flower Extract and Its Anticoagulant Activity24925623188510.21608/ejchem.2022.129350.5715ENSalsabeelElgendiPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo 11562, Egypt.MarwaEzzatPharmacognosy Department, Faculty of Pharmacy, Cairo UniversityAliElsayedPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo 11562, Egypt.AhmedSaadDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Port Said University, Port Said, EgyptAmira KamalEl MotayamPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy StreetJournal Article20220324Lantana camara L. (Family Verbenaceae) is an ornamental herb found in tropical and sub-tropical countries. It has been widely used in traditional medicine for the treatment of various illnesses. L. camara contains a large number of phytochemical compounds. Polyphenol metabolites of L. camara L. are the major bioactive constituents. Recently scientifically proven therapeutic activities of L.camara include antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, wound healing, and anti-urolithiatic activities. Limited information is available regarding the phytoconstituents and other health value of Lantana flowers. The fragmentation behavior of phenolic acid derivatives and other acids was investigated using HPLC-PDA-ESI-MS in negative mode where even minor components were detected due to the high sensitivity of mass spectrometer detector. The given acids profile led to discovery of many unreported metabolites including hydrogen-bonded dimers of acids and acids bound to sugars. The anti-coagulant activity measured by estimation of prothrombin time (PT) using normal citrated human plasma and heparin as positive control revealed that Lantana flowers and roots extracts increased the clot time relative to the control. This activity may be attributed to the high-phenolic content of the flowers as many studies have reported.https://ejchem.journals.ekb.eg/article_231885_132c6c20b4786ae570c4ee34308bdb9f.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101A novel Tubular Electrochemical Reactor with a Spiral Design of Anode for Treatment of Petroleum Refinery Wastewater25727023304710.21608/ejchem.2022.125257.5574ENGhazi FaisalNaserChemical Engineering Department - College of Engineering&ndash; Al Muthanna University &ndash;Almuthanna- Iraq0000-0002-7237-6870Thamer J.MohammedChemical Engineering Department / University of Technology / Baghdad / IRAQ0000-0002-6640-8741Ali H.AbbarDepartment of Biochemical Engineering, Al-Khwarizmi College of Engineering, University of BaghdadJournal Article20220304The use of a tubular electrochemical reactor (TER) with a novel design for batch recycle electrochemical treatment of petroleum refinery effluent was investigated. The reactor is composed from a cylindrical stainless steel cathode and a spiral porous graphite anode at its center. The impact of process factors like: NaCl addition ,current density, flow rate, and pH on the chemical oxygen demand elimination efficiency was studied using response surface methodology based on (BBD). For estimating the interaction between the response (RE %) and its independent factors, a quadratic model equation was developed. The quadratic model's accuracy was supported by its significant R2 value (92.61 %). The optimization study illustrated that NaCl addition was the most effective factor on RE% followed by current density confirming that the oxidation process is governed by indirect electrochemical oxidation rout. Results also showed that the flow rate plays an important influence in maximizing the RE% with a new correlation. The optimal working conditions were a current density ( 26 A/cm2), pH (10), NaCl addition ( 1.899 g/l) and flow rate ( 4L/min), resulting in a (COD ) elimination efficiency of 85.12% with specific energy exhaustion of 116.17kWh/kg COD.https://ejchem.journals.ekb.eg/article_233047_2f6b16d4d79245d8cd81644c19dd4f1e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Evaluation of the Upper Cretaceous Black Shales: A Case Study from Islam and Hamrawin Phosphate Mines, Qussier Area, Southern Eastern Desert, Egypt27129023303210.21608/ejchem.2022.123645.5523ENEsmatAbou El-AnwarProf. of Geochemistry Geological Sciences Dept., National Research Centre, Dokki, Giza, Egypt.0000-0001-5947-2254Journal Article20220223The Campanian-Maastrichtian parent rock of Islam and Hamrawin Mines shale from Qussier was studied from mineralogical and geochemical compositions to deduce its origin, deposition environments, tectonic setting, as well as the economic evolution. XRD patterns indicated that the study black shales are consisted of two phases, clay and non clay minerals. The Duwi Formation implies highly textural maturity. The black shales for Duwi Formation were formed under anoxic shallow marine conditions. The chemical parameters indicated that the study area was deposited under high salinity, warm and humid climate conditions. The high Fe2O3 content, some traces and REEs; Zr, Ba, Nb, Sr, Ce, Th, Y, Hf, and La concentrations as well as ICV and CIW pointed to input of recycling components derived from old sedimentary basis in a comparatively stable tectonic setting. The geochemical data, CIA, CIW and PIA values are revealed that the Duwi Formation black shales are subjected to the intensive chemical weathering either for the original basis or through transportation before deposition. The studied samples are plot in active continental margin of provenance. Black shales of Islam mines are represent the highest average of ΣREEs, ΣLREEs and ΣHREEs (233.75, 125.67 and 41.72ppm; respectively), with respect to the other neighboring mines. Consequently, the ΣREEs are increased to the direction of south Qussier. The chemical composition of black shales for the Duwi Formation had diversity sources for redox-sensitive traces and REEs in the Qussier area. Black shales of Islam and Hamrawin Mines can be classified as high-quality sources for extraction oil and gas.https://ejchem.journals.ekb.eg/article_233032_3127a4525fafdc9ee1826c41433ad5c5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Role of Pumpkin and Linseed Oils in Attenuating the Nephrotoxicity of Bisphenol-A in Mice: Biochemical, Genetic and Histopathological studies29130122933110.21608/ejchem.2022.122316.5475ENOsamaElhamalawyDepartment of Environment and Bio-Agriculture, Faculty of Agriculture, Al-Azhar UniversityFathiaAl-AnanyDepartment of Biological and Environmental Science, Faculty of Home Economics, Al-Azhar University,AidaEl MakawyCell Biology Department, Biotechnology Research Institute, National Research Centre0000-0001-8335-5381Journal Article20220216Edible plant oils have been made known to be exciting sources of bioactive compounds making them a suitable alternative in the management of some human diseases. Pumpkin and linseed oils are high in Omega-3 & Omega-6 are considered the utmost vital essential fatty acids that the body cannot create and are considered crucial for health. Bisphenol-A (BPA) plays a role in the development of chronic kidney disease, particularly in developing countries with high levels of pollution. The toxicity of BPA in mice kidney cells and the attenuating role of pumpkin and linseed oils against the deleterious effects of BPA were assessed using kidney function analysis, comet assay for DNA damage detection, and histopathological examination. In an experimental mouse model, pumpkin and linseed oils were administered orally by gavage before or together with BPA administration once a day for four weeks. BPA increased the levels of kidney function markers and the administration of pumpkin and linseed oils resulted in a successful recovery to the normal levels of these metabolites. Our results indicate that pumpkin and linseed oils can increase DNA integrity and ameliorate the histopathological defects in the kidney tissues of BPA-treated mice. The current study found that pumpkin and linseed oils have promising attenuating activity against the unwanted properties of BPA.https://ejchem.journals.ekb.eg/article_229331_378edbf1baefe582c5061930ba97738b.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101An overview of chemical composition and fungicidal activity of Olive (Olea Europea L.) Leaf Extract.30331122818810.21608/ejchem.2022.120206.5397ENHalloumaBilelChemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia.MohamedYahiaDepartment of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, 11795 Cairo, Egypt.0000-0001-8915-2921Shaima M. N.MoustafaBiology Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi ArabiaJournal Article20220205Human has been dealing with olive tree (Olea europea L.) since the beginning of ages, relying on the oil of its fruits because of its great economic and nutritional importance. Attention began in recent decades for the leaves of the olive tree for its high medicinal importance. Several studies indicated that olive leaves have multiple vital useful components and can be used medically. Also, they were proven important in treating high blood pressure, high cholesterol and diabetes, as well as anti-oxidative food additives, antibacterial and antifungal. The chemical composition of olive leaf extract indicates that it is rich mainly in oleuropein. The present mini-review gives an overview on the different methods of olive leaf extraction, the chemical composition of the extracts and its use as an antifungal agents. All the results collected showed that the extract has an antifungal efficacy against a wide range of fungus. Olive leaf extracts can inhibit the growth of Aspergillus flavus, Aspergillus Ochraceus, Penicillium sp, Fusarium moniliforme, Tricophyton rubrum, Mauginiella scaettae, Magnaporthe grisea, Candida dubliniensis, Penicillium digitatum, Penicillium italicum, Aspergillus niger, Aspergillus ochraceus, Phytophthora sp, Fusarium proliferatum and Candida albicans strains with a good percentage of inhibition providing its fungicidal activity.https://ejchem.journals.ekb.eg/article_228188_6015b53bb5da90eb866ef97775df561c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Propolis Harvesting and Extraction31332123355110.21608/ejchem.2022.122043.5469ENMohamedEl-SakhawyCellulose and Paper Department, National Research Centre, Cairo 12622, EgyptJournal Article20220216Propolis is a resin-like material produced by Beehives. Propolis has many vital applications and can be used to make various products. This review paper highlights the methods of propolis harvesting and how to increase its production. Raw propolis has limited uses, so it was essential to understand the methods used to obtain propolis extract. Standard extraction methods are based on the use of a solvent for extraction, and the commonly used solvents are alcohol, water, and glycol, each with its advantages and disadvantages. The solvent extraction method consumes a lot of time, extending for several days, so some modern extraction methods have been used to save time, such as ultrasound-assisted extraction, microwave-assisted extraction, and supercritical carbon dioxide extraction.https://ejchem.journals.ekb.eg/article_233551_157be0f753ab65d6f360b4cbdd398281.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101An Efficient Catalyst for the Fabrication of Substituted Pyrroles with Specific Nanomorphology as Potential Antimicrobial and Antioxidant Agents32333422820210.21608/ejchem.2022.126164.5596ENEslam AMostafaOrganometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, EgyptEman. S.ZarieDepartment of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki 12311, Giza, Egypt0000-0002-4211-3105Al Shimaa G.ShalabyChemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, 12622, Cairo, EgyptWahid M.BasyouniOrganometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, EgyptKhairy A. M.El-BayoukiOrganometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, EgyptJournal Article20220308Highly typical tetra-substituted pyrroles 4a-j were prepared by the condensation of 1,3-dicarbonyl compounds, benzoin, and ammonium acetate via a one-pot hydrothermal synthesis procedure in the presence of sulfamic acid (SA), as a solid-phase organic catalyst which has recently become quite popular. The efficiency of SA as a new catalyst and ZnCl2 as traditional catalyst in the synthesis of 1-(2-methyl-4,5-diphenyl-1H-pyrrol-3-yl)ethanone 4a was performed as an example for the present comparison. Scanning electron microscopy (SEM) was used to compare the morphologies of the 1-(2-methyl-4,5-diphenyl-1H-pyrrol-3-yl)ethanone films 4a that prepared by those catalysts. An appropriate ratio of sulfamic acid was enough to start the reaction with a higher yield and a higher surface area to volume ratio. Besides, it provided nanoscale-interpenetrating networks with homogenous structures. The chemical structure of the target compounds was characterized by NMR and FTIR spectroscopy. In addition, the prepared compounds were evaluated to study their antimicrobial and antioxidant activities.https://ejchem.journals.ekb.eg/article_228202_8e4d8d435fc810975dad48c7b8d414fd.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Comparative proteomics analyses of female Culex pipiens mosquito gut proteins after sugar and blood feeding using Nano LC-MS33535222942310.21608/ejchem.2022.126725.5629ENRamiElansariZoology and Entomology department, Faculty of Science, Al-Azhar university, Cairo, Egypt0000-0002-3784-5977Ahmed SaberBreamZoology and Entomology Department, Faculty of Science, Al-Azhar University, EgyptWahid HusseinEl-DabaeMicrobiology and Immunology Department, Veterinary Research Division, National
Research Centre, Dokki 12622, Giza, Egypt.Shaymaa HusseinMahmoudZoology Department, Faculty of Science, Menoufia University, EgyptJournal Article20220311Culex pipiens is a major vector transmitting a variety of arthropod-borne pathogens. Cx pipiens were collected then identified morphologically and by mitochondrial cytochrome oxidase I gene for accurate species confirmation. Mosquito's' gut plays an important role in infection susceptibility. A baseline proteomic dataset is needed to give insights into the physiology of blood-feeding and to understand functional proteins in mosquito behavior following a blood meal ultimately leading to establishing effective control strategies. As the changes in protein expression of Cx. pipiens gut after sugar and blood-feeding has not been investigated, a proteomic analysis of gut tissue was carried out using Nano LC/mass spectrometry (LC-MS) and offline matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF)-MS. There were 56 functional putative proteins in the gut of sugar-fed Cx. pipiens females and 37 proteins gut of blood-fed Cx. pipiens females with molecular weight ranging from 800.4 to 2969.4 Da and from 818.3 to 3207.6 Da for sugar and blood-fed gut females, respectively. 39 and 20 proteins were uniquely identified in sugar-fed and blood-fed, respectively, while 17 proteins were common by the two biological groups. Data are available via ProteomeXchange with identifier PXD030533.https://ejchem.journals.ekb.eg/article_229423_7113087ce932eb7944519e3b605668cc.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties35336022966310.21608/ejchem.2022.126231.5597ENMejdiSnoussiUniversity of Hail, KSA0000-0002-2309-2601AmeniGhabiUniversity of MonastirMagdy El-SadekAbidChemistry Department, College of Sciences &amp; Art, . Jouf University, Saudi ArabiaAbdullahAlthunayyanDepartment of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi ArabiaAzdaAlassafDepartment of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi ArabiaFahadAlminderejDepartment of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi ArabiaAbuzarE. A. E. AlbadriaDepartment of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi ArabiaWael A.El-SayedPhotochemistry Department, National Research Centre, Dokki, Cairo, EgyptAdelKadriFaculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.KaisAouadiDepartment of Chemistry, College of Science, Qassim University, buraidahJournal Article20220308Some novel enantiopure 3-carboxylic isoxazolidine derivatives were synthesized by stereocontrol 1,3-dipolar cycloaddition (1,3-DC) between nitrone derived (-)-menthone with alkenes derived from phenol and benzyl alcohol. Furthermore, the synthesized molecules were optimized for their drug-likeness and pharmacokinetics parameters by using in silico methods.https://ejchem.journals.ekb.eg/article_229663_0bf366ef14e4a19d1c18ab386a4b6d12.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and Molecular Docking Study of Novel Heterocyclic Compounds from Cyanoacetohydrazide36137322896110.21608/ejchem.2022.130530.5751ENEmanOmarChemistry - Faculty of Science
Zagazig UniverstyWaelShehtaDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, EgyptMohammed GommaAssyDepartment of Chemistry, Faculty of Science, Zagazig University, (Egypt)EmanEl-SaidDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, EgyptM. H.AbdellattifDepartment of Chemistry, College of Science, Taif University, Taif, 21944, Saudi ArabiaJournal Article20220330The present study reports the synthesis of some novel heterocyclic derivatives by reacting cyanoacetohydrazide in a basic medium with different electrophilic reagents. Initially, its reaction with H2O2 afforded 1,2,3-triazine-4,6(1H,5H)-dione, which upon addition to benzylidenemalononitrile under Michael's condition yielded 7-amino-4-oxo-5-phenyl-1,5-dihydro-4H-pyrano[2,3-d][1,2,3]triazine-6-carbonitrile. Azidolysis of cyanoacetohydrazide resulted in the formation of 5,8-dihydrotetrazolo[1,5-c][1,2,3]triazin-7-ol. On the other hand, heterocyclization of cyanoacetohydrazide with ethyl cyanoacetate and/or chloroacetyl chloride produced 2,5-dioxo-2,4,5,6-tetrahydro-1H-pyrazolo[1,5-b]pyrazole-3-carbonitrile and 3,5-dihydroxy-1,2-dihydropyridazine-4-carbonitrile, respectively. The later undergoes [2+3] intermolecular cycloaddition to the heteroallene system produced 4-(1,2,4-thiadiazol-3-yl)-1,2-dihydropyridazine-3,5-diol. Furthermore, Knoevenagel condensation and intramolecular heterocyclization of cyanoacetohydrazide with benzaldehyde and acetylacetone afforded 3-hydroxy-5-phenyl-4H-pyrazole-4-carbonitrile and 5,6a-dimethyl-3-oxo-1,2,3,6a-tetrahydro-3aH-furo[3,2-c]pyrazole-3a-carbonitrile, respectively. Intermolecular heterocyclization of cyanoacetohydrazide with diethyl oxalate and carbon disulphide gave 5-Hydroxy-2,3a-dihydropyrrolo[2,3-c]pyrazole-3,4-dione and 4-hydroxy-1,3a-dihydro-3H-pyrazolo[3,4-c]isothiazole-3-thione, respectively. All reactions proceeded in good to excellent yields and the synthesized compounds were identified by different spectroscopic techniques. All the obtained compounds are virtually screened by molecular docking on the target protein 1KZN by the MOE for potency as antibacterial agent. Also, pharmacophore and ADME studies were applied. Efficient binding to the target protein was found for some of the synthesized compounds.https://ejchem.journals.ekb.eg/article_228961_b8c702d353b1080dce27ad088b59078b.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Electronic Structure, Global Reactivity Descriptors and Nonlinear Optical Properties of Some Novel pyrazolyl quinolinone Derivatives. DFT approach37538523019810.21608/ejchem.2022.104957.4843ENEL-ShimaaIbrahimchemistry department, faculty of education, ain shams universityHussienMustafaChemistry Department, College of Science, Cairo University, University Ave, Dokki, Giza, 12613, EgyptShimaaAbdelhalimDepartment of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo,Journal Article20211108The electronic and tautomeric structures of some novel pyrazolyl quinolinone derivatives are investigated using DFT/B3LYP/6-311++G (d, p) level of theory. The results of MO calculations show that all the studied compounds 1- 6 are planar, as indicated from the calculated dihedral angles. The calculated EHOMO and ELUMO energies of the studied compounds can be used to describe the extent of charge transfer in the studied molecules and to calculate the global properties; the chemical hardness (η), global softness (S), electrophilicity (ω), and electronegativity (χ). The effect of substituents of different strengths on the geometry, energetic and nonlinear optical properties are analyzed and discussed. The choice of these substituent's in the studied compounds aims at creating a push-pull system on pyrazolyl quinolinone structure which pave the way to understand their nonlinear optical properties. The calculated nonlinear optical parameters (NLO); polarizibilty (α), anisotropy of the polarizibility (Δα) and first order hyperpolarizibility (β) of the studied compounds have been calculated at the same level of theory and compared with the proto type Para-Nitro-Aniline (PNA), show promising optical properties. 3D- plots of the molecular electrostatic potential (MEP) for some of the studied compounds are investigated and analyzed showing the distribution of electronic charge density of orbitals . describing the electrophilic and nucleophilic sites of the selected molecules.https://ejchem.journals.ekb.eg/article_230198_ea19f92ae884e3db19dc13a2aec3c5a9.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.38739822818710.21608/ejchem.2022.117920.5313ENRania H.TahaDepartment of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.EsmailEl-FakharanyProtein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt.0000-0002-0724-8477ZienabEl-ShafieyDepartment of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.AidaSalmanDepartment of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.MaiMansourDepartment of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.MohamedYahiaDepartment of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, 11795 Cairo, Egypt.0000-0001-8915-2921Journal Article20220123The present investigation relates to the new method of preparing schiff base of 4-(2-Hydroxy-1,2-diphenyl-ethylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one as well as the preparation of metallic compounds with certain ions such as (La(III), Gd(III), Co(II), and Cd (II)) in normal and nano-size and their biological applications of their ability to treat colon and breast cancer cells without affecting normal cells. These synthesized compounds have been characterized using different analytical techniques including physicochemical studies such as elemental analysis, electrical conductivity, Uv-visible, IR, nuclear magnetic resonance (NMR), mass spectrometry, magnetic and thermal studies as well as imagining using transmission electron microscopy (TEM). In vitro, the anti-cancer activity of these synthesized compounds was investigated, and their mechanism of action was detected. The results proved that these compounds have the anti-cancer activity against colon cancer (Caco-2) and breast cancer (MCF-7) cell lines at very low concentrations up to 8.27 mg/ml. It was found that the Cd (II) compound showed the highest selectivity against cancer cells without affecting the normal (Vero) cells with selective index (SI) values about 62 times for breast cancer cells and about 51 times for colon cancer cells.https://ejchem.journals.ekb.eg/article_228187_46dbf772a588142638064a112ab151e3.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101A review of Recent Advances in The Estimation of Pharmaceutical Products Using Hydrophilic Interaction Chromatography (HILIC) Technology39941723709010.21608/ejchem.2022.121396.5443ENAyad KadhimFadhilGeneral Directorate of Education, Ministry of Education, Karbala, Iraq0000-0002-6210-2956Ashraf SaadRasheedDepartment of Chemistry, College of Sciences, University of Baghdad, Al-Jadriya campus, 10071 Baghdad, Iraq.Mohammed Jasim M.HassanChemistry, college of Science, University of Mustansiriyah: Baghdad, Baghdad, IQJournal Article20220212Liquid Chromatography as a separation tool has made significant strides in a systematic study. The most widely used chromatographic process is reverse-phase liquid chromatography (RPLC), which uses polar mobile and hydrophobic stationary phases. However, specific polar composites are challenging to study using this approach. Normal-phase liquid chromatography (NPLC) is another separation process that uses polar stationary phase and organic eluents. When analyzing polar compounds, NPLC produces asymmetric chromatographic peak forms and low-efficiency separations. HILIC is a promising alternative approach for polar compound analysis. HILIC is a separation process that blends the stationary phases of the NPLC method with the mobile phase of the RPLC technique. Hydrophilic interaction liquid chromatography (HILIC) was used to separate small molecules, medicinal compounds, metabolites, contaminants, sugars, peptides, oligosaccharides, proteins, and amino acids, among other liquid chromatographic separations. Tiny polar composites can be efficiently separated on polar stationary phases using HILIC. The target of the study was to look at the different ways to characterize HILIC stationary phases and how they can be used to separate polar compounds in complex matrices. Since processes other than hydrophilic partitioning may exist, the features of the hydrophilic stationary phase may influence in some situations, restricting the selections of ion intensity, mobile phase construction, and buffer pH value available. Increasing our knowledge of HILIC retention activity broadens the range of liquid chromatography applications. HILIC systems bio uses are also discussed. This paper gives a broad description of how HILIC has been used in pharmaceutical testing in various sample matrices, including plasma, pharmaceutical dosage forms, environmental samples, serum, plant origin samples, and animal origin samples. This study also reflects on the most modern and a selection of papers in pharmaceutical science from 1991 to the suggestion deadline in 2020, which deal with examining various mechanisms using HILIC.https://ejchem.journals.ekb.eg/article_237090_97c8b1a778be828cf1dd5c346c5fa088.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and mesomorphic properties of non-symmetric liquid crystal dimers stabilized by benzothiazole and substituted aromatic imines41942923155310.21608/ejchem.2022.122190.5478ENElham A.Al-TaifiChemistry Department, Faculty of Science, Sana’a University, Sana’a, YemenGuan-YeowYeapLiquid Crystal Research Laboratory, School of Chemical Sciences, Universiti Sains
Malaysia, 11800 Minden, Penang, MalaysiaOmaima F.Ibrahim3Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, EgyptIslam S.MaraeChemistry Department, Faculty of Science, Assiut University, Assiut 71516, EgyptSafiyyah A. H.Al-WaleedyChemistry Department, Faculty of Science, Taiz University, Taiz, YemenEtifyBakhiteChemistry department, Faculty of Science, Assiut UniversityJournal Article20220217Two new homologous series of non-symmetric liquid crystal dimers N-(4-(n-(4- (benzothiazol-2-yl)phenoxy)alkyloxy)benzylidene)-4-bromoanilines and N-(4-(n-(4- (benzothiazol-2-yl)phenoxy)alkyloxy)benzylidene)-4-methoxyanilines in which the methylene spacer of CnH2n with even parity of n ranging from 4 to 12 and the substituents of bromo and methoxy attached to respective aniline fragments have successfully been synthesized and characterized. The salient feature of these series can be attributed to the conversion of non-mesogenic units of benzothiazole and aromatic imine units to mesogens through the formation of dimers. All the title compounds exhibit enantiotropic nematic phases. The smectogenic properties also prevail among the series containing Br entity wherein the spacers are C8H16, C10H20 and C12H24. In general, the isotropization temperatures for both series were seen to descend with the increase in the spacer length. Comparison among the compounds possessing Br and OCH3 substituents shows that the anisotropic properties are governed partially by the presence of substituent residing in the aniline unit.https://ejchem.journals.ekb.eg/article_231553_194340cfb873aaed25078d3159ba49e8.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis of MCM-48 contains NaCl and Surfactant as Catalyst in the Esterification of Nyamplung Oil (Calophyllum inophyllum L.) to Biodiesel43143723656110.21608/ejchem.2022.104616.4836ENLaKoloDoctoral Program of Chemistry Science, Hasanuddin University Graduate School, Makassar, 90245, IndonesiaDepartment of Chemistry Education, Bumi Hijrah University, Tidore, 97852, Indonesia0000-0002-3421-9938Nunuk HarianiSoekamtoDepartment of Chemistry, Hasanuddin University, Makassar, 90245, Indonesia0000-0001-8281-1752Firdaus-Department of Chemistry, Hasanuddin University, Makassar, 90245, Indonesia0000-0001-5985-9299PaulinaTabaDepartment of Chemistry, Hasanuddin University, Makassar, 90245, Indonesia0000-0001-7327-5505Journal Article20211106This research looked at the thermolability of the MCM-48-NaCl catalyst in the esterification of nyamplung oil. The use of various calcination temperatures was to investigate the thermolabile catalyst's optimization. The activity of the catalyst in the esterification was determined using the acid-base titration method. The active site and thermolabile state of the catalyzed were determined using XRD and FTIR characterization. In the esterification, the CTAB-MCM-48-NaCl catalyst performed 12.36% better than the conventional catalyst (H2SO4). The catalyzed achieved its optimum condition at calcination of 650 °C, with a reaction activity of 21.44%. Bronsted acid and surfactants are active sites of catalysts that play a role in the reaction. The presence of NaCl did not significantly affect the thermolabile resistance of the MCM-48-NaCl catalyst. This catalyst has the potential for esterification and hydrocracking hydrocarbon compounds of nyamplung oil suitable for biodiesel.https://ejchem.journals.ekb.eg/article_236561_215ad28ebd576cfa156bd8a3db9f40ab.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Internals Design of Continuous Stirred Tank Electrochemical Reactor Based on the Residence Time Distribution Approach43944523254310.21608/ejchem.2022.122976.5502ENRaghad S.MahmoodChemical Engineering Department, College of Engineering, University of BaghdadAmmar S.AbbasChemical Engineering Department, College of Engineering, University of BaghdadJournal Article20220220The design of the reactor internals of the two-phase Continuous Stirred Tank Electrochemical Reactor (CSTER) was studied under different conditions. Two types of air distributors were tested (cubic and circular) according to the bubble size produced by each, measured by a high-speed camera. Two impeller types were tested (Rushton turbine 4 and 6 blades). The results indicate that the bubble size increases with increasing airflow, but the cubic distributor has a smaller bubble diameter than the circular distributor under all conditions. The value of average time for the 4-blades turbine was more than it for the 6-blades turbine at a lower mixing speed, but at 600 rpm, the 6-blade turbine has a value of average time closer to the ideal space-time.https://ejchem.journals.ekb.eg/article_232543_49607f12be212039a987587f4ce53ad2.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Purification and Immobilization of Aginase from Fenugreek Plants44745223313610.21608/ejchem.2022.124718.5553ENAlyaa IbrahimMohamedChemistry Department
Faculty of Science
Mansoura University
Mansoura
EgyptHamed M.El-ShoraChemistry Department
Faculty of Science
Mansoura University
Mansoura
EgyptNeven AhmadSalahBiochemistry Division-Chemistry Depatment- Faculty of Science-Mansoura University- EgyptMagdy M.YousefChemistry Department
Faculty of Science
Mansoura University
Mansoura
Egypt0000-0003-4205-5379Journal Article20220301Abstract:<br /><br />Introduction: Enzymes are recorded in all living organisms where they speed up and regulate the chemical reactions that crucial for the life of organisms. L-Arginase (L-arginine urea hydrolase, or amidinohydrolase, EC 3.5.3.1) is hydrolytic enzyme. It is a divalent cation-dependent and plays an essential role in nitrogen metabolism through converting L-arginine to L-ornithine plus urea. Aim of the work: This work aimed to isolate, purify and comparing the characteristics of the free and immobilized L-arginase from Fenugreek. Material and methods: L-arginase was purified from fenugreek plants. L-arginase was purified successfully to homogeneity from fenugreek by 80 % ammonium sulphate, DEAE-cellulose and Sephadex G200. L-arginase was immobilized on calcium alginate and chitosan. Reuse of immobilized L-arginase was tested through 7 cycles. Results: The results in the present investigation showed that the optimal pH for the free L-arginase was 8.5 whereas the immobilized enzyme expressed optimal pH at 9.0. On studying the effect of temperature on the free and immobilized enzyme showed that the optimal temperature was 40°C for the free enzyme and shifted to 50ºC for the immobilized form on both Ca alginate and chitosan. Conclusion: The presence of L-arginase in fenugreek suggests that this plant may be a potential plant source for developing the industrial biosynthetic production of L-ornithine.https://ejchem.journals.ekb.eg/article_233136_c2e093f18eb699eab26ef42a296bdb73.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Utilities of Pyrazolone and Its Derivative in Heterocyclic Synthesis and Their Biological Applications45347823423010.21608/ejchem.2022.123629.5521ENTahaEldebssorganic chemistry department, faculty of science , cairo university0000-0002-1922-5037MohamedEldebssDepartment of Biotechnology, Faculty of Agriculture, University of Cairo, Giza 12613, EgyptSolimanSolimanChemistry Department, Faculty of Science, Cairo University0000-0002-9798-1073Journal Article20220223Several pyrazoles with various substitutions at various positions were prepared starting from pyrazole and its derivatives. The biological activities of newly synthesized compounds were tested and evaluated in vivo and vitro for different types of diseases and showed good results, in addition to some examples of some pyrazoles Containing heterocycles were established as drugs such as Celecoxib Lesopitron Sulfaphenazole Rimonabant Tebufenpyrad Betazole Tepoxalin Pyriprole Deracoxib Mavacoxib. Pyrazole (1,2-Diazole). It is a heterocyclic aromatic organic compound with a 5-membered ring of three carbon atoms and two adjacent nitrogen centers with the molecular formula C3H4N2 ; molar mass, 68.08 g mol−1; melting point, 66–70 °C, boiling point, 186–188 °C ; basicity (pKb), 2.5https://ejchem.journals.ekb.eg/article_234230_0eabfc1690cfc9e1e61d8da713ba9525.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101An Overview On Gliricidia Sepium In The Pharmaceutical Aspect: A Review Article47949623027110.21608/ejchem.2022.129184.5713ENAya AhmedWafaeydepartment of pharmacognosy, faculty of pharmacy, Cairo universitySeham Salah EldinEl HawaryPharmacognosy Department, Faculty of Pharmacy, Cairo University0000-0002-6823FaridKirollosdepartment of pharmacognosy, faculty of pharmacy, Cairo universityMohamed FayedAbdelhameedPharmacology department, medical division, national research centre0000-0001-6100-6498Journal Article20220323The use of medicinal plants dates from ancient times. Humans learned to seek therapy in the barks, leaves, fruits, flowers, and other parts of plants as a result of many years of struggles against illnesses. Gliricidia sepium (Jacq.) Kunth. ex. Walp., is one of the most important plants in pharmacognosy and medicine fields because it serves as a reservoir for potent bioactive compounds such as saponins, flavonoids, volatile oils, and other bioactive compounds that have been extracted from various parts of it. Gliricidia sepium is the topic of much research due to its numerous traditional applications, which include treating coughs, asthma, curing urticaria, rash, burns, scabies, dermatitis, acting as an antipruritic on the skin, and treating bacterial and protozoal infections. Many medicinal uses for Gliricidia sepium have been discovered over time, including cytotoxic activity, anti-microbial activity, anti-bacterial activity, anti-inflammatory activity, antioxidant activity, thrombolytic anti-sickling activity, wound healing, mosquitocidal activity, and anthelmintic activity.https://ejchem.journals.ekb.eg/article_230271_6a9b860b8f9b7c8ebd6871fe3bb15091.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101In Vitro Release of Curcumin as an Anticancer Drug from Gelatin Nanoparticles49750723316210.21608/ejchem.2022.129597.5738ENSALWA Abd Elkhalek TharwatAHMEDEgyptian Drug Authority (EDA), Giza, EgyptWael SabryMohamedDepartment of Polymers and Pigments, National research centre, Giza, Egypt0000-0001-5246-7620Sabrnal HanafyEl HamoulyPolymer Laboratory, Department of Chemistry, Faculty of Science, Menoufia University, Shibin el Kom, Egypt.Nabila AhmedMaziadHead of polymer chemistry department, Department of Polymer Chemistry, National Center for Radiation Research and Technology (NCRRT), Nasr City, Cairo, Egypt.Mahmmoud SayedAbd ElmonamEgyptian Drug Authority (EDA), Giza, Egypt.Journal Article20220328This study focuses on combine nanoscale structure with biomolecules to create new biological and nanotechnology applications. Gelatin nanoparticles was prepared by nanoprecipitaton method with various parameters and utilized the optimum as a carrier for curcumin as anticancer drug, the obtained nanoparticles had a homogenous well-defined morphology that confirmed using transmission electronic microscopy and FT-IR, as well a curcumin was loaded on gelatin nanoparticles by emulsification linkage technique in the presence of SLES as emulsifier, and the EE of the drug was controlled by the polymer concentration, the emulsifier concentration, and the drug to polymer ratio. The results showed that GNps exhibit high Encapsulation Efficiency (EE) which reached to 82%. Additionally, studying the curcumin release profile at different pH values (1.2 and 7.4) at 37 °C for 72 h showed that the amount of drug released at acidic pH 1.2 is higher than that of pH 7.4 and also the release rate had slow and sustained.https://ejchem.journals.ekb.eg/article_233162_3b5b9ee6b1499c701fc2d6cf0db5eda7.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Full Profiling of The Orange By-Products and Their Potential Effects with Chromium on Obesity Complications in Rats50951927899610.21608/ejchem.2023.176415.7221ENEbtehal AAltamimNutrition & Food Science (PHD), Department pf Physical Sport Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia0000-0003-1070-0644Journal Article20221122A disorder identified as obesity includes having too much body fat. It is a medical ailment that increases the risk of several syndromes and other health issues. Around the world, 19.5% of the adult population is obese, which is a widespread condition. The current study seeks to explore the chemical constitutes, bioactive substances, antioxidant activity, and impacts on obesity problems in rats of orange by-products, peel, and pulp integration with chromium. While orange pulp has larger amounts of carbohydrates, minerals (Mg, Fe, and Zn), vitamins (E, B1, and B6), and bioactive substances than orange peel, the latter has higher levels of total protein, fiber, minerals (Na, K, Ca, and P), vitamins (A and C), total polyphenols, flavonoids, and carotenoids. In contrast to the control normal group, rats fed a diet-stimulated obesity diet (DIO) had a higher body weight (416.76%), blood leptin (142.84%), glucose (95.17%), and hyperlipidemia (cholesterol (219.77%), triglycerides (131.22%), and low-density lipoprotein cholesterol (341.59%). Because orange peel and pulp contain antihyperlipidemic and anti-diabetic substances that lower serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol and raise high-density lipoprotein cholesterol, consuming them alone or in combination with chromium partially reversed these negative changes and decreased the likelihood of atherogenesis. When orange peels and pulp were combined with chromium, there showed noticeable synergistic effects. These results lay a foundation for the use of food industry by-products, with or without chromium, in the early detection and treatment of obesity. Additionally, the current study suggests adding orange by-product powder and/or extracts to our everyday meals, beverages, dietary supplements, and pharmaceutical formulations.https://ejchem.journals.ekb.eg/article_278996_b51b3d0561ddd7c809dfc479d8f9ce2e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate52153023009710.21608/ejchem.2022.125128.5563ENShimaa A.MahmoudChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.MohamedTahaMaterials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt.0000-0003-3726-4491Eman S. H.KhaledChemistry department, faculty of science, Beni-Suef university, Beni-Suef, EgyptAhmed A.Abdel-khalekChemistry department, faculty of science, Beni-Suef university, Beni-Suef, EgyptReham A.MohamedChemistry department, faculty of science, Beni-Suef university, Beni-Suef, Egypt0000-0002-9220-9500Journal Article20220303Tranexamic acid (TXA) have antifibrinolytic properties and finds wide applications in pharmaceuticals, most used in cardiac, orthopaedic, urological, gynaecological, and obstetric surgery. Complexes of tranexamic acid with some metal ions show antimicrobial and anti-tumor activity. Oxidation-kinetic study is of much importance in understanding the mechanistic profile of Cr-TXA complex in biological systems. Kinetics of oxidation of [CrIII(TXA)(H2O)5]2+ by periodate has been spectrophotometrically studied under pseudo order conditions over 293-313 K, pH (3.20-4.20) range, and ionic strength of 0.30 M for a set of periodate concentrations. The initial oxidation product is certainly Cr(V). The reaction is first order dependent on complex concentration. The pseudo-first order rate constant, kobs increased with decreasing proton concentration, indicating that the deprotonated form of the chromium (III) complex is the reactive species. An inner sphere mechanism has been proposed for the oxidation process. The thermodynamic activation parameters are also reported.https://ejchem.journals.ekb.eg/article_230097_9523e737b6680dad9a458b5e7e225555.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.53154323126410.21608/ejchem.2022.125283.5572ENAmina HamedAlobaidiDepartment of Biochemistry, College of Medicine, Kirkuk University, Kirkuk, Iraq0000-0002-8495-3452Abdulghani MohamedAlsamaraiDepartment of Medicine, College of Medicine, Tikrit University, Tikrit, Iraq0000-0002-7872-6691Journal Article20220303To clarify the role of TNF-α, IL-18, osteopontin, lipoprotein (a) and paraoxonase in psoriasis in Iraqi community this study was conducted. Cross-sectional study included 94 subjects with psoriasis vulgaris, with a mean age of 37.5 ± 11.6 year. Serum osteopontin, IL-18 and TNF-α were determined using Enzyme linked immunosorbent assay kits. The mean serum levels of TNF-α, IL-18, OPN, and LP (a) were significantly higher in individuals with psoriasis as compared to controls. In contrast, PON 1 mean serum value was significantly lower in psoriasis compared to controls. Odd ratio indicated a significant association between increase in TNF-α, IL-18, OPN and Lp(a) and the decrease in PON1 in our cohort study. Disease severity significantly correlated with serum levels of TNF-α, IL-18 and Lp (a), while inversely correlated with serum levels of PON 1. TNF-α was with high predictivity in monitoring psoriasis severity and response to treatment. The elevation of serum IL-18, OPN, LP(a) and reduction of PON1 indicated that these biomarkers may play a role in psoriasis pathogenesis. The significant correlation of serum levels of TNF-α, IL-18 and LP (a) with PASI and inverse correlation of PON1 with PASI are useful biomarkers for monitoring of disease severity and treatment outcome.https://ejchem.journals.ekb.eg/article_231264_27b65b21abe8d2a442d59db335de5ba5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Antioxidant Potential of Eight selected Kenyan Medicinal plants54555323753810.21608/ejchem.2022.127658.5666ENMohamedAbd-elfattahDepartment of Molecular Biology and Biotechnology, Pan African University Institute of Science, Technology and Innovation, JKUAT campus, Juja, Nairobi, 62000, 00200, Kenya.Special Food and Nutriation Res.Department, Food Tech. Res. Institute, Agricultural Research Center, Giza, 12613 Egypt.0000-0002-9827-5891NaomiMainaDepartment of Molecular Biology and Biotechnology, Pan African University Institute of Science, Technology and Innovation, JKUAT campus, Juja, Nairobi, 62000, 00200, Kenya.Chemistry Department, Jomo Kenyatta University of Agriculture and Technology, Juja, Nairobi, 62000, 00200, Kenya.Patrick GachokiKareruChemistry Department, Jomo Kenyatta University of Agriculture and Technology, Juja, Nairobi, 62000, 00200, Kenya.Hany A.El-ShemyDepartment of Molecular Biology and Biotechnology, Pan African University Institute of Science, Technology and Innovation, JKUAT campus, Juja, Nairobi, 62000, 00200, Kenya.Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza,12613 EgyptJournal Article20220315Adding of antioxidants to our daily food may reduce the risk of diseases caused by free radicals as a result of oxidative stress in the human body. In this study, eight selected Kenyan medicinal plants (Terminalia brownii, Aloe secundiflora, Prunus africana, Carissa edulis, Tithonia diversifolia, Warburgia ugandensis, Croton megalocarpus and Launaea cornuta) were studied for their potential antioxidant activity. The levels of polyphenols and flavonoids were determined using standard methods. Plant parts were extracted using water and different organic solvents. Prunus africana acetone extract had the highest levels of phenolic compounds while Tithonia diversifolia water extract had the lowest amount. The antioxidant activity was highest in Terminalia brownii acetone extract and lowest in Croton megalocarpus, Diethyl ether leaves extract, respectively. This trend was followed by antioxidant potency composite index of the medicinal plant extracts. Terminalia brownii extracts had the highest antioxidant activity and potential, followed by Prunus africana extracts due to the higher total phenolic content found in the latter medicinal plants. Total phenolic content was positively correlated with FRAP, ABTS and DPPH values. Based on the antioxidant potency composite index calculated and the overall antioxidant index, it can be concluded that the extracts from T. brownii bark and P. africana bark can be recommended as a potential natural source of antioxidants appropriate for utilization in nutritional and pharmaceutical fields. Further evaluation of the bioactive compounds and antioxidant activities in living models need to be investigated.https://ejchem.journals.ekb.eg/article_237538_a74cffac4f337b64585254d0e83ca18c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid55556128691510.21608/ejchem.2022.132916.5870ENZainab FaiyqSaeedDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of MosulMohanad YakdhanSalehDepartment of Chemistry, College of Education for pure science, University of Mosul0000-0003-2320-5167Ghufran ThanoonSadeekdepartment of chemistry, college of Education for pure science0000-0002-0347-9454Journal Article20220412In this paper, a new series of substituted 1, 2,4-triazines was prepared by reacting 4-amino sulfanilic acid with substituted benzaldehyde to form the corresponding Schiff base compounds (1-5), and then reacting two moles of O-methoxy benzaldehyde with hydrazine to form a compound (6) and these compounds reacted with Schiff base (1-5) by applying the Diels-alder reaction in the presence of benzene as a solvent and refluxed it to cyclized into substituted of 1,2,4- triazines derivatives (7-11). Depending on the physical and spectroscopic properties of the prepared compounds that were identified, infrared spectroscopy and nuclear magnetic resonance were used. An evaluation of the biological activity of the prepared compounds was conducted and it gave anti-bacterial results, such as gram-positive and gram-negative when compared with known antibiotics.https://ejchem.journals.ekb.eg/article_286915_f9e61ea6a4f50048b855bd9ec4221f4f.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228566120230101Thermodynamic Studies Of Cu (II) complex of new bidentate Schiff base ligand type (NO) derived from Mebendazol.56357228691410.21608/ejchem.2022.128827.5703ENTaghreed BaqerAlwanchemistry department,college of Ibn al haithaum education, University of BaghdadTaghreed.b.a@ihcoeduMiad HassanJeburMinistry of Education, Al-Najaf – IraqShaimaa AhmadHassanCollege of Remote Sensing &amp; Geophysics , Al Karkh University of Science, Baghdad, Iraq0000-0001-5635-9889Journal Article20220321In the present work, the proceeding ligand as well as its complexes have been studied, through the studying of effects of the temperature that ranges from (25o to 45oC) and a variety of the concentrations on molar conductivity values from Arinus' law application. The limiting molar conductivity of Ligand (L) and [M(L)2Cl]Cl.H2O complex in different temperature was measured, by which decomposition constant and uniform molar conductivity are determined, thermo-dynamic parameters (i.e. ΔH, ΔG and ΔS) had been estimated then discussed. Results have shown that the value of the molar conductivity is increased with the increase of the temperature and decreased with the increase of the concentration by using DMSO solvent. The process of the dissociation is an exothermic process for the complex (M+2 = cu), in addition to that, characterizing this prepared complex has been carried out through measuring the value of the melting point, FTIR spectra, UV-Visible spectra, and the measurements of the magnetic susceptibility, and later in comparison to the ligand and metal solutions.https://ejchem.journals.ekb.eg/article_286914_c9ba7e0e5d9d9dbf96638575ee9e57f4.pdf