National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-2285545201210012- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds579593142710.21608/ejchem.2012.1427ENJournal Article20110306 <span style="font-size: xx-small;">3-(3,4-DICHLORO (or 3,4-dimethyl)benzoyl)] prop-2-enoic acids 1 ..... react with o-xylene and </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">p</span></span></em><span style="font-size: xx-small;">-xylene under Friedel-Craft's reaction conditions giving acids 2 or 3, respectively. They were converted into the corresponding pyridazinone 4 derivatives upon treatment with N</span><span style="font-size: xx-small;">2</span><span style="font-size: xx-small;">H</span><span style="font-size: xx-small;">4 </span><span style="font-size: xx-small;">in boiling ethanol . The pyridazine derivatives 9,10,11 can be synthesized as a pro-drug due to their more potent and less peripheral effects than non-acidic or weakly acidic NSAIDs. Also, triazolopyridazine, oxazinone and furanone were also investigated. </span>https://ejchem.journals.ekb.eg/article_1427_613ca974ffc4c1363f54bcdd3a3f634a.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111031Synthesis of Some New Pyrimidines and Pyrrolo [2,3-d] Pyrimidines as Potential Antimicrobial Agents595608142810.21608/ejchem.2011.1428ENJournal Article20110803CYCLOCONDENSATION reaction of compound 1 with oxalyl
choloride in acetone and dimethyl formamide afforded pyrrolo
[2,3-d] pyrimidine derivative 2 , which was reacted with p-amino
acetophenone, p-aminobenzenesulfonamide (sulpha drugs), thiosemicarbazide
, ethyl chloroacetate and benzoyl acetonitrile to give
compounds 3, 4a-c, 5, 6, and 7, respectively. Condensation reaction of
acetyl derivative 3 with 3, 4, 5-trimethoxybenzaldehyde afforded
compound 8. 2(1H)-pyridone and imino pyridine derivatives 9, 10 were
obtained by the reaction of compound 8 with ethyl cyanoacetate or
malononitrile in presence of ammonium acetate. Moreover, chalcone
derivative 8 was condensed with thiourea to give compound 11. Michel
condensation reaction of 3 with ethyl cyanoacetate and 3-
indolcaroxaldehyde leads to the formation of the pyridine 12 in one step
reaction. Bromination of compound 13 afforded 14, which was reacted
with thiourea to give compound 15. Furthermore, compound 13 was
allowed to react with hydroxyl amine hydrochloride and phenyl
hydrazine to give compounds 16 and 17, respectively. The antimicrobial
activity of some of synthesized compounds was evaluated.https://ejchem.journals.ekb.eg/article_1428_dea24f2c3952ccf6989f0c0f94b567d6.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111031Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones609622142910.21608/ejchem.2011.1429ENJournal Article20111127
<span style="font-size: xx-small;">3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with .......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results. </span>https://ejchem.journals.ekb.eg/article_1429_eb7783db5df9e8ca778905ce08621e91.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Infrared Absorption Spectra of Some Gamma Irradiated Borate Glasses Containing Nickel and Titanium Ions623637143010.21608/ejchem.2011.1430ENJournal Article20101221 <span style="font-size: small;">INFRARED absorption spectroscopy for a number of borate number of borate glasses containing nickel and titanium nickel and titanium ions was carried out before and after subjecting to gamma radiations. All glasses were melted in Pt-2% Rh crucibles in an electrically heated furnace at 1100°C for two hours. </span>
All measurements were recorded using a Jasco FT/IR-300 E infrared spectrophotometer in the range of (4000-200) cm
<span style="font-size: xx-small;">-1</span><span style="font-size: small;">. </span>
The response of the glasses studied to γ-rays radiation is related to the formation, accumulation and annihilation of induced defects and hence the observed changes in the FTIR spectra can be utilized to confirm the changes in the structure arrangements of the building groups after irradiation.https://ejchem.journals.ekb.eg/article_1430_6af509893187cf7af7bcaab0ba9cffb5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Reaction of 1, 3-Di-(1-piperidyl)-2-nitropropane with Thiophenol and Hydrogen Sulfide and Preparation of 5-Nitrohexahydropyrimidin-2-thione639646143110.21608/ejchem.2011.1431ENJournal Article20101227 <span style="font-size: xx-small;">THE CHEMISTRY and biological activities of Mannich bases …….have received considerable interest. The alkylation of amines, active methylene compounds and thiols with Mannich bases has been the subject of extensive studies as the products are of considerable synthetic and pharmaceutical interest. </span>https://ejchem.journals.ekb.eg/article_1431_ac19feeb58dc02fcdd3f7c6cc644f49e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Characterization of Synthesized Phenylthiazoly-liminomethyls and Some Metal-Complex Derivatives Irradiated with γ-Rays647662143210.21608/ejchem.2011.1432ENJournal Article20110227 <span style="font-size: xx-small;">Treaction between the amine, 2-amino-4-phenylthiazole and the aldehydes salicylaldehyde and o-phthalaldehydic acid, respectively in 1:1 molar ratio. The metal-complex derivatives of Fe</span><span style="font-size: xx-small;">3+</span><span style="font-size: xx-small;">, Co</span><span style="font-size: xx-small;">2+, </span><span style="font-size: xx-small;">Ni</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">, Cu</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">, Zn </span><span style="font-size: xx-small;">2+ </span><span style="font-size: xx-small;">and La</span><span style="font-size: xx-small;">3+ </span><span style="font-size: xx-small;">were also prepared for each ligand. The elemental analysis, IR, UV-Visible, </span><span style="font-size: xx-small;">1</span><span style="font-size: xx-small;">H NMR and MS spectral analyses served the structure elucidation. </span>
The products were γ-irradiated and the post-radiation UV-Visible results were studied. Some radiolysis products were suggested with the assistance, of the obtained MS results. The TGA events described the thermal stability and coordination establishment of the metal derivatives.
In association with the UV-Visible data and magnetic behavior of metal- complexes, the octahedral geometry was suggested for most of the investigated products. However, Cu-complexes revealed distorted arrangement. Most of the derivatives exhibited low molar conductance values illustrating the association of amines in the coordination sphere and the non-electrolyte behavior.
The antimicrobial activity tests showed significant inhibition against the Gram-positive
<em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">Bacillus subtilis </span></span></em><span style="font-size: xx-small;">(NCTC-1040) by the Cu-complexes. Nevertheless, only the Cu-complexes of II displayed similarly against </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">Streptococcus pyogens </span></span></em><span style="font-size: xx-small;">(ATCC-19615). The Co- complex of II revealed also significant inhibition against the Gram-negative </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">E.coli </span></span></em><span style="font-size: xx-small;">as well as against the fungus </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">Aspergillus fungatus </span></span></em><span style="font-size: xx-small;">. </span>https://ejchem.journals.ekb.eg/article_1432_0396f747a2e9ffc05ef25a543ec411e6.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Eco-Friendly Technology for Textile Printing Using Innovative Self Printing Paste663678143310.21608/ejchem.2011.1433ENJournal Article20110825 <span style="font-size: xx-small;">TARA SEEDS were subjected to mechanical crushing sieving and soaking in water followed by filtration to obtain galactomannan gum. Rheological properties of this gum were investigated before and after the gum was treated with sodium hydroxide (0. 5 to 10%). </span>
Experience gained from this study was used to concurrently isolate eco-friendly galactomannan gum and safety natural dye from Tara seeds in one step process. Evaluation was made of the obtained self printing paste for printing cotton, wool and silk fabrics in presence and absence of different mordants. It was found that pastes of Tara gum treated with sodium hydroxide at a range of 0.5 to 2 % exhibit non-Newtonian pseudo plastic behavior, whereas the latter is converted at higher alkali concentrations to non- Newtonian Thixotropic behavior; similar to pastes prepared from the untreated gum. The colored printing paste, which was isolated from Tara seeds, could successfully be used in printing of silk, wool and cotton fabrics without any additives, but the shade was only confined to one color. It was also found that the K/S values of silk and wool are practically equal meanwhile they are higher than that of cotton. Mordants enhance printing and create different colors, depending upon their nature. For example the K/S of printed cotton samples displays the highest value with tannic acid and the lowest with alum and follows the order: tannic acid > copper sulphate > ferrous sulphate > potassium dichromate > alum ; an order which is also valid for wool and silk fabrics.
Fabrics printed by the self printing paste acquire color fastness to rubbing, to washing, and to perspiration ranging from very good to excellent, besides, resistance of the prints to alkali treatment.https://ejchem.journals.ekb.eg/article_1433_d54e0d4ebb65d2352b1874327c21549e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Functionally Substituted 1,2,4-Triazoloquinoline, Tetrahydro-quinolinone and Benzotriazolotriazine Derivatives from 5,5-Dimethylcyclohexan-1,3-Dione and Arylmethylenemalonic Acid Derived Michael Acceptors679690143410.21608/ejchem.2011.1434ENJournal Article20110905 <span style="font-size: xx-small;">SEVERAL new functionally [1,2,4]triazolo[1,5-</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">a</span></span></em><span style="font-size: xx-small;">]quinoline-4- …… carbonitriles (8a-c) and [1,2,4] triazolo[1,5-</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">a</span></span></em><span style="font-size: xx-small;">]quinoline-4-carbox-amides 12a,b were prepared from </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">Nʹ</span></span></em><span style="font-size: xx-small;">-(5,5-dimethyl-3-oxocyclohexen-1-yl)benzohydrazide (5) and arylmethylene nitriles 2a-c and 2d,e, respactively.Reacting 2-oxo-3</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-size: xx-small;">-indol-3-ylidene malonic acid derivatives 3a,b with 5 afforded dioxospiro [3</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-size: xx-small;">-indole-3,4ʹ-quinoline]-3ʹ-carbonitrile (15) and 2- oxo-[1</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-size: xx-small;">] indol-3-ylcyanoacetate (17), respactively.Treating 5 with the enaminoester 18 gave hexahydro-7,7-dimethyl-2,5-dioxoquinolin-3-yl]benzamide (20). Coupling of 5 with the aryl diazonium salts and heteroaryl diazonium salts gave the hydrazones (21) and tetrahydro-[1,2,4]triazolo[5,1-c] [1,2,4] benzotriazine-6-ylidene)benzohydrazide (26). </span>https://ejchem.journals.ekb.eg/article_1434_8226e0274cf208fb64b25bc29e6a22a5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines691701143510.21608/ejchem.2011.1435ENJournal Article20111127ASERIES of new 6,7,8,9-tetrahydrodibenz[ <em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">b,f</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">][1,4]oxazepin-11(10</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)-ones (3) was prepared by alkylation of salicylamides 1 with 2-chlorocyclohexanone followed by cyclodehydration of the resulting 2-cyclohexyloxybenzamides 2. New pyrido [2,3-</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">b</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">] [1,4]benzoxazepin-6(5</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)-ones (8) were prepared by reacting salicoyl chlorides 4 or their corresponding acids 5 with 3-amino-2-chloropyridines 6 followed by treatment of the resulting amides 7 with sodium methoxide. Some of the new compounds were subjected to preliminary screened for their tranquilizing effect.</span></span>https://ejchem.journals.ekb.eg/article_1435_227b6e4db5fb7508040d6b4cc989e3ad.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228554520111231Studies on Substituted Heteroarenes: New Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo[4,3-bpyridine, Pyrano [3,2-c]quinoline, Benzo [f] chromene, Benzo[h] chromene, Chromeno [8,7-h]chromene, Chromeno[6,5-f] chromene and 2H-chromene Derivatives703721143610.21608/ejchem.2011.1436ENJournal Article20111124SEVERAL new pyrazolo[4,3- <em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">b</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">] pyridines </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">7a,b</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">( </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">were prepared by reacting arylmethylenenitriles </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1a,c or 1i,j</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">( </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">with 4-nitrosoantipyrine </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">4</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">(</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">. Reacting 1a,b,d with 4-azidomethylcarbonylantipyrine 8 gave 2-aminopyrrole (14). Pyrano[3,2-c] quinolines (20a,b and 23) were obtained by reacting 4-hydroxyquinoline (15) with 1g, h;2b, respectively.Reaction of 1 with naphthalenediols 24,27 and 29 yield naphthodipyrans 26a,b,28a,b and 30a,b, respectively. Spironaphthodipyrans (32,33) and spironaphthopyrans (36,37) were prepared through reaction of 2a with naphthalenediols (24,27,34 and 35), respectively. Condensation of thioxothiazole (38) with 3,5-dibromo-2-hydroxybenzaldehyde gave 2</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-chromene-3-carboxamide (42). 38 also reacted with 1c and 2a to gave 3,5-dicyanopyridines (45 and 47), respectively. Reaction of 2-cyano-</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">N`</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-(1-thiophen-2-yl)ethylidene) acetohydrazide (49) with 1a,b afforded 3,5-dicyanopyridines (53).</span></span>https://ejchem.journals.ekb.eg/article_1436_fb14e259d21314d49c30eddd90a7508b.pdf