National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Study of Binary and Ternary Complexes of Co(II), Ni(II), Cd(II), Fe(III), and UO2(II) Complexes of Amino Carboxylic Acid Derivatives and Pyridine, Synthesis, Spectroscopic Characterization, Thermal Investigation and Biological Activity177202121110.21608/ejchem.2010.1211ENJournal Article20100127TWO Schiff base ligands of organic acid moity, vis., N- (2- carboxyphenyl) salicylideneimine, (H <span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">L</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">) and N-(2-carboxyphenyl) thiopheneimine, (HL</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">) have been synthesized by the interaction of salicylaldehyde and 2- thiophenecarboxaldehyde with 2- amino benzoic acid.Co (II), Ni (II), Cd (II), Fe (III) and UO</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">(II) complexes of these ligands have been prepared. Also, the ternary complexes were prepared by using pyridine (Py) as a secondary ligand. All synthesized compounds were identified and confirmed by elemental analysis, molar conductance, IR, </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">HNMR, UV-Vis, mass spectra, magnetic measurements, and thermal analysis. The molar conductance data reveal that these complexes are non </span></span><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA"><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA">– </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">electrolytic, 1:1 and 1:2 electrolytic nature of the metal complexes. The ligands are coordinated to the metal ions in a terdentate manner with ONO/ONS donor sites of the carbonyl oxygen, azomethine nitrogen and phenolic oxygen or thiophenic sulphur. An octahedral structure is proposed for the prepared metal complexes. The thermal stability of the metal complexes is evaluated. The synthesized ligands, in a comparison to their metal complexes also were screened for their antibacterial activity against bacterial species, </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">bacillus cereus, bacillus subtilis </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">and </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">Escherichia coli</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">. The activity data show that some metal complexes to be more potent / antibacterial than the parent organic ligands against one or more bacterial species.</span></span>https://ejchem.journals.ekb.eg/article_1211_f1ef67a9fb359de04288936d133057aa.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Reaction of 2,6-Bis(4-azidobenzylidene)-4-methyl-cyclohexanone with Organophosphorus Reagents. Synthesis of Some Benzylidene-1, 2, 3-triazole Derivatives203214121210.21608/ejchem.2010.1212ENJournal Article20100131TRIPHENYLPHOSPHINE (1) reacts with 2,6-bis(4-azido-benzylidene)-4-methylcyclohexanone (4) to give the respective triphenylphosphinylidenetriaz-1-enyl (5a) and triphenylphosphinylidene- amino (5b). Moreover, reaction of aryl azide (4) with trisdimethy-laminophosphine (2) in refluxing toluene afforded the new products (6a, b). On the other hand, phosphorus ylides (3a-d) react with azidobenz-ylidene (4) to give the corresponding 1,5-disubstituted-1,2,3-triazoles (7a-d) and triphenylphosphine oxide. Possible reaction mechanisms are considered and the structural assignments are based on compatible analytical and spectroscopic results.https://ejchem.journals.ekb.eg/article_1212_7f42686a0c9ea6f5407651d2a83f9e23.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Preparation and Characterisation of Ink Formulations Based on Sod. alginate and Natrosol as Thickeners for Jet Printing on Nylon Carpet215231121410.21608/ejchem.2010.1214ENJournal Article20100208
<span style="font-size: xx-small;">TO PREPARE and characterise various ink formulations for …….inkjet printing on nylon 66 carpet, various ink formulations were prepared using CI Acid Red 57, Natrosol and Sod.alginate thickeners, ethylene glycol, diethylene glycol, isopropanol with auxiliaries. The inks were characterised for their rheological, wetting and storage stability properties. The inks were jetted using a Printos P16 drop-on-demand jet print-head onto nylon 66 carpet materials. The printed images were characterised using an ImageXpert system. It was found that the inks containing the sod.alginate and natrosol thickeners at the optimum ratio gave good printing and image properties, such as optical density, drop size, and depth of penetration into the substrate at pH 4-5. The optimised ink formulation was found to have good storage stability. The study focused on ink formulations based on CI Acid Red 57. Ink formulations based on other colorants could also be studied in order to assess the applicability of the ink formulation system found for other colorants. The ink formulations developed could find use in industrial scale printing. </span>https://ejchem.journals.ekb.eg/article_1214_4c1933f2e8dce4ef1862d0eeb2285ec4.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Spectrophotometric Determination of Ornidazole, Secnidazole and Tinidazole in Pharmaceutical Preparations Based on Formation of Dyes233241121510.21608/ejchem.2010.1215ENJournal Article20100222SIMPLE and accurate spectrophotometric method was developed for the assay of ornidazole (I), secnidazole (II) and tinidazole (III) in tablet dosage form. The method depends on the reduction of the drugs with zinc dust and hydrochloric acid followed by condensation with p-hydroxy benzaldehyede at 50 <span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">o</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">C to produce colored chromogens having absorbance at 402 nm for drugs I, II and III. The optimum experimental conditions for the proposed method were </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">optimized and Beer’s law was obeyed in the concentration ranges of </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">20-300 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">μg ml</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">for drugs I and II 20-</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">250 μg ml</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">for drug III. The apparent molar absorptivities of the resulting colored products were found to be 1.00x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">, 1.24x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">and 1.70x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">L mol</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">cm</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">, whereas Sandell sensitivities are 4.5x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-6</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">, 3.9x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-6 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">and 6.7x10</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-6 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">μg </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">cm</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">for I, II and III, respectively. The proposed method was applied successfully for the analysis of the investigated drugs in tablet form. The results obtained were statistically compared with a reported method using the </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">student’s t </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-test and F-variance ratio tests.</span></span>https://ejchem.journals.ekb.eg/article_1215_f0fb00748671781618718ba5bba34d83.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities243255121710.21608/ejchem.2010.1217ENJournal Article20100225
<span style="font-size: xx-small;">THE 2-DAIZO-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide cou coupled with either malononitrile or ethyl cyanoacetate to give the hydrazo derivatives 4a and 4b, respectively. The latter products underwent hetero-cyclization to give pyrazole, pyrimidine and pyridazine derivatives. The antimicrobial evaluation of the newly synthesized products was measured and most of the products showed interesting activities. </span>https://ejchem.journals.ekb.eg/article_1217_6a913d5fc42b92e41142104f1672c902.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Synthesis of Some Analogs of Bradykinin Hormone Using Modified Solid Phase Peptide Synthesis and Microwave Technique (Part 1)267277121910.21608/ejchem.2010.1219ENJournal Article20100317
<span style="font-size: xx-small;">THREE analogs of Bradykinin, (Lys</span><span style="font-size: xx-small;">1</span><span style="font-size: xx-small;">) BK, (Lys</span><span style="font-size: xx-small;">9</span><span style="font-size: xx-small;">) BK and (Lys</span><span style="font-size: xx-small;">1, 9</span><span style="font-size: xx-small;">) …… BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of Arg</span><span style="font-size: xx-small;">1,9 </span><span style="font-size: xx-small;">by Lys on the salt bridge between the guanidine group of Arg</span><span style="font-size: xx-small;">1 </span><span style="font-size: xx-small;">and the carboxyl group of Arg</span><span style="font-size: xx-small;">9</span><span style="font-size: xx-small;">, was investigated. The analogues will be tested </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman,Times New Roman; font-size: xx-small;">in vitro </span></span></em><span style="font-size: xx-small;">for their effect on heart rate of rats and in isolated organ for the arterial pressure. </span>https://ejchem.journals.ekb.eg/article_1219_1611eb0c15171b6132588fe0326668f7.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies279299122110.21608/ejchem.2010.1221ENJournal Article20100329NEW peptide series of 2-(2-oxo-2H benzo[h] chromen-4-yl) acetyl <span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;">........</span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">derivatives 3</span></span><strong><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-</span></span></strong><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">5, 15-20 and their corresponding methyl esters 6-14 were synthesized. Structures of the synthesized products were characterized by correct elemental analysis, IR, Mass and </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H-NMR spectroscopy. DNA binding activities were performed. Some synthesized compounds showed high binding affinity against DNA. Virtual screening using molecular docking studies of the synthesized compounds were performed, the molecular docking results indicate that, most of the synthesized compounds are more suitable inhibitors against carbonic anhydrase isozyme (CA) than reference drug.</span></span>https://ejchem.journals.ekb.eg/article_1221_624f7b6f05d15bee4a76a5ab841bc1e5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Synthesis and Investigation of 2-Propylpentanoyl Amino Acid and Dipeptide Conjugates as Novel Anticonvulsants301314122210.21608/ejchem.2010.1222ENJournal Article20100412
<span style="font-size: small;">THE CENTRAL nervous system (CNS) requires the anticipation of a number of neuro-active amino acids and peptides</span><span style="font-size: xx-small;">(1) </span><span style="font-size: small;">for its normal function. Thus, - aminobutyric acid (</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">GABA</span></span></em><span style="font-size: small;">), glycine, histadine, tyrosine, arginine, taurine, aspartic and glutamic acids, are involved in the synthesis of neurotransmitters neuromodulators, or their neuro-agonists. In particular, glycine is an inhibitory neurotransmitter</span><span style="font-size: xx-small;">(1) </span><span style="font-size: small;">that is found in mammalian proteins and tissues. Its role primarily appears to involve the inhibition of neuronal activity in the striatum, substantia nigra and cerebellum. Analougously, -aminobutyric acid (GABA)</span><span style="font-size: xx-small;">(2) </span><span style="font-size: small;">is a constituent of mammalian tissues particularly the brain and spinal cord. It is synthesized in GABA ergic neurons, and interacts with postsynaptic receptors to exert its inhibitory effects. </span>
On the other hand, the collective terms “convulsive disorders”, “seizure disorders” and “cerebral seizures” are currently, synonymously considered, for epileptic convulsions. Such disorders are common neurological symptoms of a complex nature and, frequently, undetermined etiologies.
With the existing medications, however, approximately 25% of epileptic patients are not seizure free, regardless of their therapy optimization. In addition to the apparent health hazards, considerable socio-economic problems are intrinsically encountered with the prevalence of untreated epilepsy.
In that context, 2-propylpentanoic acid (
<em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">generic name: Valproic Acid (</span></span></em><span style="font-size: small;">trade names</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">: Depakene®</span></span><strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">,</span></span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">“Abbott Lab”</span></span></em><span style="font-size: small;">) is one of the essential antiepileptics, that are still predominant in the current clinical practice</span><span style="font-size: xx-small;">(3)</span><span style="font-size: small;">. </span>https://ejchem.journals.ekb.eg/article_1222_d0d318ac90ebafb0938cb2c2a82c6851.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228553220100430Chemistry of Phosphorus Ylides, Part 30. Reaction of Camphorquinone Derivatives with Active Phosphacumulenes and Stabilized Phosphonium Ylides315327122310.21608/ejchem.2010.1223ENJournal Article20100414THE REACTION of the bifunctional camphorquinone(1) , its monophenylhydrazone (13) and monooxime (16) with the active phosphacumulenes (2) was performed. Phosphanylidene- cyclobutylidenes (5), azitidine bicyclo heptanones (14) and phosphanylidenes (17) were obtained, respectively. On the other hand, the stabilized phosphonium ylides (6) react with the above mentioned substrates (1, 13, and 16) to give the corresponding oxaphosphetane (8), phosphanylidene (10) oxatricycloundecadiene (12), azaphosphetidines (15) and the azatricyclo- undecadienone (19).https://ejchem.journals.ekb.eg/article_1223_9b18b8e66991250e5d376cb701c65ee7.pdf