National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesize and Characterization of a Novel Nano Graphene Oxide Sulfolene derive3215322315687710.21608/ejchem.2021.26377.2536ENHawraaRadyDepartment of Chemistry, College of Science, University of Misan, Maysan, Iraq0000-0003-4819-6535SafaaNajimDepartment of Chemistry, College of Science, University of Misan, Maysan, Iraq0000-0002-0759-0184Journal Article20200322Carbon-based nanoparticles, particularly graphite nanoformulations have seized plenty of fancies currently, groundbreaking development is being made with these formulations and the potentials are limitless. Graphene Oxide has a huge molecular structure, carries many functional groups together with hydroxyl, carboxylic, carbonyl and epoxide companies which are best for esterification and amidation reactions. on this observe Nano graphene oxide synthesized using changed Hummer approach and novel graphene oxide sulfolene derive. The synthesized nanocomposites characterised the usage of diverse devices consisting of X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (ft-IR), Proton atomic attractive reverberation (H1-NMR), territory emanation filtering electron magnifying instrument. The crystallite size for the newly synthesized compound (GOSO) from diffraction styles of X-ray turned into calculated the usage of equations: (Debye – Scherer) equation and Williamson – corridor equation and as compared between them.https://ejchem.journals.ekb.eg/article_156877_96b07eeca4bce251901ce80b8f02a968.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Estimation the Efficiency of Sunlight UV on Inactivation COVID-19 Virus3225323415891510.21608/ejchem.2021.39728.2810ENWisam Kadhum H.Al-HashemiCollege of Science, Al-Nahrain University, Baghdad, Iraq0000-0001-6578-7017Dheaa Sh.. ZageerForensic DNA Center and College of Science, Al-Nahrain University, Baghdad, IraqHussam K.RisanCollege of Engineering, Al-Nahrain University, Baghdad, IraqJournal Article20200818The solar UV radiation coming from the sun is considered as the main source of microbial germicide and environmental sterilization. The objective of this study is to estimate the UV dose amount and time required to inactivate coronaviruses by solar exposure. The published trials on 254-nm UV inactivation dose under ultraviolet light exposure of coronaviruses families and the equivalent microbe in terms of D90 (ultraviolet dose for 90% inactivation), or any other dose or/and genome size was examined and summarized. The mean with its confident interval of the unified D90-254 nm inactivation dose of all trials was assumed as ultraviolet susceptibility of the SARS-CoV-2 (COVID-19) virus. The inactivation dose spectrum (sensitivity envelope) for coronaviruses and equivalent microbes as a function of the UV wavelength equivalent to UVB range (280 to 320 nm) was adopted from literature. The UVB solar measurement intensity at Baghdad's geographical location was used over a year at every fifteen minutes and converted from a lump sum to solar spectrum per wavelength in the range of 280 to 320 nm using a simplified mathematical model. A composite action spectrum was drawn that including the virus sensitivity spectrum normalized to 254 nm, UVB solar measurements spectrum, and inactivation effective dose spectrum for coronaviruses. The area under the inactivation effective dose spectrum was calculated numerically to find the equivalent solar flux. The time required to inactivation SARS-CoV-2 (COVID-19) virus is predicted for each value of UVB lump sum intensity to simulate the time required to sterility the outdoor surfaces at all months within Baghdad geographical station. This work should be useful to provide the decision-makers with a clear picture of the sterilization process management of the outdoor surfaces and curfew timing arrangement.https://ejchem.journals.ekb.eg/article_158915_0bc785beb78545ccf1abe73ddaea97df.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, structural, thermal and biological studies for new Schiff base derived from Isoniazid and it's complexes with metal ions3235324315776710.21608/ejchem.2021.42643.2861ENShaimaa AhmadHassanCollege of Remote Sensing &amp; Geophysics , Al Karkh University of Science, Baghdad, Iraq0000-0001-5635-9889Sajid MahmoodLateefDepartment of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, IraqJournal Article20200912A new ligand of Schiff base (L") [methyl (E)-(6-((2-isonicotinoylhydrazineylidene) (phenyl) methyl) -1H - benzo[d]imidazol-2’-yl) carbamate] (3) was prepared from the reaction of isoniazid (1) and mebendazole (2) in presence of HBr (48%) in ethanol. The complexes were prepared from the reaction metal ions M(II)=V, Mn, Co, Ni, Cu, Cd, Zn, and Hg with (L") in ethanol and acetone. All compounds were characterized by FT-IR, 1H NMR,13C NMR, UV.Vis, Mass spectroscopy, magnetic susceptibility measurements, atomic absorption, thermal analyses, elemental microanalysis, molar conductance, and chloride content. The results obtained when evaluating the antibacterial and antifungal activities of the compounds prepared against two types of bacteria and one type of fungi showed that the complexes are more effective than free ligand, while based on a date for all techniques It has been suggested that all prepared complexes have octahedral geometry.https://ejchem.journals.ekb.eg/article_157767_9c55b5ba67f78f7832757abdb7996922.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Factorial Design Optimization of Microwave Digestion for Macro and Microelements in Pregnant Women and Diabetics Multivitamin/Multielement Preparations by Inductive Coupled Plasma Mass Spectrometry (ICPMS)3245325415687910.21608/ejchem.2021.49815.3027ENABUZARALBADRI7587 king Saud 90000-0003-1167-4329Mohamed ElmukhtarAbdelAzizDepartment of Chemistry, Sudan University of Science & Technology, Khartoum, SudanHassanAhmmadDepartment of Chemistry, Faculty of Science, University of Khartoum, Khartoum, SudanJournal Article20201117In the present work, the microwave digestion procedure for the determination of Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Se, V and Zn in multivitamin/multielement (MVM) preparations used for pregnant women and diabetics employing ICP-MS, was optimized by factorial design 33 (27 runs). The microwave digestion conditions temperature (160, 180 and 200ºC), acid mixture volume (3.9, 5.2 and 6.5 ml) and radiation period (10, 15 and 20 min) were selected as factors. Moreover, a multiple response (MR) was built to establish a compromise conditions between the elements. The optimum conditions were found to be 160ºC, 6.5 ml, 20 min for temperature, acid mixture volume and radiation period, respectively. The procedure was validated using standard reference material (SRM3280) and elements recoveries were found to be in the range 88 - 107% and was applied to determination of Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Se, V and Zn in commercial MVM samples obtained from the local market.https://ejchem.journals.ekb.eg/article_156879_834f891ffc860afd2b4c79e605f2a75e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Effect of Refuse Derived Fuel Ash on the Hydration Characteristics of Portland Cement3255326415688110.21608/ejchem.2021.53751.3117ENEisa El-SayedHekalPhysical Chemistry and Building Materials, Faculty of Science, Ain Shams University, Cairo, EgyptWael HusseinHegazyChemistry ,Faculty of science, Suez university, Suez, Egypt.Rasha MostafaKamelChemistry, Faculty of science, Suez university, Suez, Egypt.Khaled AbdelrehimMoustafaChemistry ,Faculty of science, Suez university, Suez, Egypt.0000-0001-6103-6339Journal Article20201216The use of alternative fuels in Portland cement manufacturing reduces the amount of emissions such as CO2 and NOX gases. Also, it causes a considerable energy cost reduction. In addition, the use of alternative fuel has a positive impact on environment as a result of reduction of solid waste disposal. Therefore, the aim of this work is to investigate the effect of residual ashes produced from using RDF solid waste as biofuel in Portland cement manufacture on its properties. The solid waste used in this study is refuse derived fuel (RDF) mainly from municipal waste. The effect of adding different ratios of the ash, produced after burning such solid waste, to Portland cement on its hydration characteristics was investigated. This is done through the determination of standard water of consistency, initial and final setting times, compressive strength, chemically combined water content as well as the phase composition of the hydration products via the XRD examination. The ratios of ash used were: 0.0, 0.5, 1.0, 1.5 and 2.0% by weight of Portland cement. The samples with RDF ash showed relatively high values of compressive strength compared to blank sample at early ages of hydration up to 7 days.https://ejchem.journals.ekb.eg/article_156881_f09bac3f4af69a53d9c88d2d52cf9089.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Protective Effect Of Drug Loaded Nanoparticles On Brain Toxicity In Experimental Animals3265327315342710.21608/ejchem.2021.55927.3196ENMohamed AliShalabyChemistry Department, Faculty of science, Menoufia University, Shebin El-Koum, Egypt.0000-0003-1830-2376Adel A.-H.Abdel-RahmanChemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, EGYPT.0000-0003-3319-8191IbrahimZaidChemistry Department, Faculty of science, Menoufia University, Shebin El-Koum, Egypt.EmanYounessDepartment of Medical Biochemistry, National Research Centre, Cairo, Egypt.0000-0002-6492-1680NadiaMohamedDepartment of Medical Biochemistry, National Research Centre, Cairo, Egypt.Journal Article20201230Salicylates are the group of chemicals that has salicylic acid as the parent compound and have the ability to treat inflammation, pain syndromes, brain and cardiovascular disorders. The present study was designed to investigate the protective effect of loaded sodium salicylates on nanoparticles to treat brain toxicity induced by cisplatin and decrease the drug side effects. Cisplatin 20 mg/kg BW was given alone or in combination with sodium salicylate loaded on nanoparticles (Si-Sc-NPs) [100 mg/kg BW] for three weeks. The obtained results indicate that Si-Sc-NPs decrease oxidative stress markers such as malondialdehyde (MDA), nitric oxide (NO), and paraoxonase-1 (PON-1) activity in brain. There were also decreased in Monocyte Chemo-attractant Protein-1 (MCP-1) activities and Nuclear Factor kappa β (NF-kβ) level of brain tissue while the Butyrylcholinesterase (BChE) activities of brain tissue increased after Si-Sc-NPs treatment. Histopathological results showed that cisplatin group showed several neurodegenerative changes, on the other hand, group treated with Si-Sc-NPs +Cis showed improvement in almost brain structure and mild pyknotic nuclei and apoptotic neurons were observed.https://ejchem.journals.ekb.eg/article_153427_86fac7118632fd8997c03a2d2b68ff62.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Chemical Constituents and Seedlings Growth of Dalbergia Sissoo Roxb. as Affected by Magnetic Diluted Seawater and Bio fertilization Treatments3275328717046610.21608/ejchem.2021.72866.3622ENA.M.Z.SarhanFaculty of Agriculture, Cairo University, Egypt.Amira Sh.SolimanNatural Resources Department, Faculty of African Postgraduate Studies, Cairo University, 12613, Egypt.E.N.Al AtrashHorticultural Research institute, Agriculture research center ( A.R.C. ), Egypt.Ahmed M.SakranHorticultural Research institute, Agriculture research center ( A.R.C. ), Egypt.Journal Article20210420This trial was conducted to investigate the effect of magnetized diluted seawater and bio fertilization on seedlings growth and chemical constituent of Dalbergia sissoo . during the two successive seasons of 2016 /2017 and 2017/2018 at the experimental farm of El-qanater El Khairia Horticultural Research Station, Egypt. Three diluted seawater at concentrations of (2000, 4000 and 5000 mg1-1) as well as control (Nile Water) have taken and four treatments were used namely magnetized diluted seawater alone, biofertilizer with mixtures of Cyanobacteria (algae of Anabaena sp. and Nostoc sp.), biofertilizer plus magnetized technique and the control which non- magnetic and non- biofertilizer. The obtained results demonstrated that different salinity levels significantly reduced increment of seedling height, stem diameter, leaf area, root length and fresh and dry biomass, whereas the high levels of 5000 mg1-1salinity neither the seedlings irrigated with separately saline water nor were treated with magnetization or bio fertilization survived, also salinity caused a reduction in total chlorophylls and total carbohydrates in contrast proline content increased, mineral nutrition's N, P and K % decreased whereas Na increased consequently K+/ Na+ ratio decreased. Treatment of exposure the seedlings to magnetized diluted seawater or non-saline significantly increased all parameters of plant height, stem diameter, leaf area, root length and fresh and dry weight biomass compared to control, also bio fertilization as alone or as a mixture with magnetic device resulted in an increase in total chlorophylls , total carbohydrates in the stem, proline content in leaves and the absorption elements of N, P and K % raised while, Na+ content decreased consequently K+/ Na+ ratio increased.<br /> Therefore, the current study cleared that seedlings of Dalbergia sissoo tolerated salinity level up to 4000 mg1-1 and the magnetization or bio fertilization ameliorated most of the growth parameters and enhanced the status of chemical constituents producing healthy seedlings.https://ejchem.journals.ekb.eg/article_170466_0604c0a1a94f04e6c27718d4a435b07b.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Investigation of the Influence of Membrane Type on the Performance of Microbial Fuel Cell3289329615776810.21608/ejchem.2021.57995.3247ENHayder A.WaheebDepartment of Chemical Engineering, College of Engineering, University of Baghdad, Baghdad, Iraq.Ahmed FaiqAl-AlalawyDepartment of Chemical Engineering, College of Engineering, University of Baghdad, Baghdad, Iraq.Journal Article20210113In this work, microbial fuel cell (MFC) design of five chambers was used to investigate the effect of four types of membranes which are cation exchange membrane (CEM), Cellulose Triacetate membrane (CTA), thin film composite membrane (TFC), and proton exchange membrane (PEM). To study the influence of the membrane type on the cathode performance, the four cathode chambers were filled with 20 g/l NaCl catholyte and the sodium acetate of 1.5 g/l was supplied to the central chamber as anolyte. The results revealed that the membrane proton selectivity plays an important role in the cathodic reduction reaction for electrical generation and water production. It was observed that the PEM has a significant effect on the power generation with a maximum power density of 20.492 mW/m2 with water production of 4.21 g/day. Whereas the competition of the other cations to the proton transfer was clearly observed by using the CTA membrane with power production of 12.646 mW/m2, and the abundance of the water production of 178.16 g/day was attributed to the water transport across the CTA membrane. For studying the influence of the membrane type on the anode performance, the sodium acetate of 1.5 g/l was supplied to the four chambers as an anolyte at a flow rate of 0.0272 cm3/sec and the central chamber were filled with 20 g/l NaCl catholyte. The salt reverse transfer from the cathode chamber to the anode chamber across the CTA membrane contributed to increasing the anolyte electrical conductivity and consequently increased the power production to 12.555 mW/m2. Meanwhile, the effect of the proton selectivity and the electrical resistance of the other membrane were observed in the other chambers. Thus, the usage of CEM, TFC, and PEM produced electrical power of 6.751, 3.004, and 9.712 mW/m2 respectively.https://ejchem.journals.ekb.eg/article_157768_b16a8a76dc46fee8b19db9d6caf235ce.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Performance Evaluation of Dual Purposes Solar Heating System Using Heat Pipe Evacuated Tube Solar Collector3297330315959910.21608/ejchem.2021.58120.3251ENH.H.El-GhetanySolar Energy Department, National Research Centre, Dokki, 12622, Giza, EgyptS.A.HassanSolar Energy Department, National Research Centre, Dokki, 12622, Giza, EgyptJournal Article20210114The aim of this work is to develop dual purposes solar heating system using a heat pipe evacuated tube solar collector. The heat transfer fluid between the thermal loads and the solar collector loop was heating oil. The study provided two thermal loads; a solar water heating system and a solar baking/cooking system that had experimentally investigated under various weather conditions. The experimental pilot unit was installed in the Solar Energy Department, National Research Centre, Giza, Egypt. Several test runs were performed to measure all assigned parameters that affect the system performance. The system is designed to provide hot oil surrounding the inner vessel of the baker with a temperature up to 250o C while the raw food can be baked/cooked and the outlet thermal energy can be used for heating water via an immersed coil in the hot water storage tank; then the relatively cooled oil is returned to the solar collector via hot oil circulating pump. The tested system can be positively contributed to baking and cooking purposes and providing hot water as well. It is considered an environmentally friendly system and can significantly enhance sustainable communities. The system is capable to produce hot water temperature up to 85 oC and an average temperature of about 60 oC during the day which is suitable for residential purposes and industrial process as well The auxiliary heating system can be an electric source in case of using in urban areas and can be renewable energy source like biogas or hydrogen fuels in rural and isolated areas.https://ejchem.journals.ekb.eg/article_159599_3564601ac43bc62b6d5ff88a9cd99b5d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Structural and Morphological Analysis of Nano Sized Anions Doped Hydroxyapatite3305330915688610.21608/ejchem.2021.54675.3274ENALISALEHDepartment of Chemistry, College of Science, University of Misan, Misan, Iraq0000-0001-9755-7427AliRaheemDepartment of Chemistry, College of Science, University of Misan, Misan, Iraq0000-0002-1489-7176HindSalehDepartment of Chemistry, College of Science, University of Misan, Misan, Iraq0000-0002-9430-7462Journal Article20210127Inorganic sulphate and silicate is required by all mammalian cells to function properly, it is the most abundant anion in the human plasma. Sulphate ions are the major source of sulphur which is considered an important element for sustenance of life as it is present in the essential amino and is required by cells to function properly.This paper aimed to compare the constitutional and physical property of pure hydroxyapatite (HA) doped with different kinds of anions such as sulphate ions (SO42-) and silicate ions (SiO44-). The pure phase of HA, SHA (SO42- doped HA), and SiHA (SiO44- doped HA) were successfully synthesised using microwave-assisted precipitation technique method. The acquired materials were recognize using X-ray diffractometer (XRD), Fourier transforms infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray (EDX) techniques. The consequence shows that incorporation of SO42- and SiO44- ions revealed shrinkage along with a-axis and expansion with c-axis. FTIR show diminished in the intensity of the OH group with an addition of anions. The particles shape significantly decreased with incorporation of SiO44- ions and changed to rod shape with addition of SO42-. The Ca/P ratios were in acceptable values. Based on the outcomes, demonstrated that the anions were successfully integrated in the HA crystal with no decomposition in HA phase.https://ejchem.journals.ekb.eg/article_156886_0886651553b92b9cc0d8e1227734dc88.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Chemical Fractionation and Risk Assessment of Some Heavy Metals in Soils, Assiut Governorate, Egypt3311332115690310.21608/ejchem.2021.59371.3276ENSalmanSalmanGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.0000-0002-2173-0438EsmatAbou El-AnwarGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.0000-0001-5947-2254AhmedAsmoayGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.0000-0001-6102-8961HamedMekkyGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.0000-0003-3396-3770WaelAbdel WahabGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.AhmedElnazerGeological Sciences Department, National Research Centre, Dokki, Giza, Egypt.0000-0002-7338-0935Journal Article20210123Toxic elements behavior in Egyptian soil need more studies for the enhancement of soil quality and human health protection. The current study focuses on the mobility assessment of chemical species of As, Pb, Cr, Ni, Cu and Co in soils due to anthropogenic emission using sequential extraction (SE) and risk assessment code (RAC). Generally, the studied soils are alkaline calcareous loam soil. It has a low organic matter (OM) that ranges from 1 to 3.8% and is enriched with As, Pb, Cr, Ni, Cu and Co, which preferentially accumulate in soil clay and silt fraction. SE revealed that the non-residual (bioaccessible) fraction contains about (70.7%) As, (65.2%) Co, (58.8%) Cr, (28.4%) Cu, (6.8%) Ni and (64.5%) Pb, indicates the risk of pollution with As, Co, Cr, and Pb. RAC values indicated a high risk of soil pollution with As, medium risk of Co and Pb, low risk of Cu and Ni, and no risk of Cr. The results pointed out the geogenic source of Cr, mixed source of Co, Cu, and Ni and the anthropogenic source of As and Pb. The spatial distribution analyses of these metals indicated the role of urbanization, traffic, and industry on the releasing of toxic metals into the environment.https://ejchem.journals.ekb.eg/article_156903_01eee40bb4ec7d5a23acfc3e4c04e389.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Potentiometric Determination of Mepivacaine Hydrochloride Local Anesthetic Drug in Pharmaceutical and Biological Fluids Using Ion Selective Electrode3323333415959710.21608/ejchem.2021.50147.3300ENTamer AwadAliEgyptian Petroleum Research Institute (EPRI), 11727, Cairo, Egypt.0000-0002-5897-0005GehadMohamedChemistry, Faculty of Science, Cairo UniversityNaglaaAbd El-HamidChemistry, Faculty of Science, Cairo UniversityJournal Article20210130The objective of this work is to determine mepivacaine hydrochloride (MPVHC) as local anesthetic drug. Modified carbon paste ion-selective electrode was used for the determination of MPVHC in different dosage forms and biological fluids. The study depends on potentiometric titration of MPVHC drug using modified carbon paste (MCPE) as end point indicator electrode. The effects of the paste composition, different conditioning parameters and foreign ions on the electrode performance were investigated and response time of the electrode has been studied. The results obtained showed that carbon paste electrode modified with sodium tetraphenyl borate-MPV ion pair gives the highest potential break at the end point, Nernstian slope, wide concentration range and lower detection limit than the reinckate-, phosphotungestic- and phosphomolybdic-MPV ion pairs. The fabricated electrode obtained Nernstian response of 57.71±0.67 mV decade-1 in the concentration range of 3.1×10-7 – 1.0×10-1 mol L-1 for MCPE electrode. The electrode was found to be operating within the pH range of 3.0–8.0 and exhibited a fast response time (about 14 s), low detection limit of 3.1×10-7 mol L-1 and long lifetime (98 days). The electrode showed high selectivity to the MPVHC drug in the presence of different organic, inorganic and amino acids. The electrode was successfully applied for the determination of MPVHC in pharmaceutical preparations and biological fluids (urine and plasma) with high percent recovery and low standard and relative standard deviation values. The results obtained applying this potentiometric electrode are comparable with British pharmacopeia. The method validation parameters were optimized and the method can be applied for routine analysis of MPVHC drug.https://ejchem.journals.ekb.eg/article_159597_166df07ef038ea476a68873fe6fb27ab.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Tailoring Nano-Copolymer/CNTs Composite and its Application in Drug Delivery3335334915690410.21608/ejchem.2021.60541.3303ENMohamed KamalDarwishChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptMohamed ShabanSaidPhysics Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.
Physics Department, Faculty of Science, Islamic University of Madinah, P. O. Box: 170, AlMadinah Almonawara 42351, Saudi ArabiaRokaya AlySobhPolymer and Pigment Department, National Research Centre, Giza, Egypt0000-0002-5004-2087Ahmed AhmedAbdel-khalekChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptJournal Article20210131This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these ground-breaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.https://ejchem.journals.ekb.eg/article_156904_a0e7e4f219135ef5a68a958e7f400827.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Design, Synthesis, Characterization and Anticancer Evaluation of Novel Mixed Complexes Derived from 2-(1H-Benzimizadol-2-yl)aniline Schiff base and 2-Mercaptobenzimidazole or 2-Aminobenzothiazole3351336415858210.21608/ejchem.2021.60640.3305ENFahad M.AlminderejQassim University College of ScienceArouaLotfiQassim University College of ScienceJournal Article20210131Two Schiff base ligand ((benzimidazol-2-phenyl)iminomethyl)phenol (HL1) (1) and 2-(1-H-benzimidazol-2-yl)phenyl)imino)methyl) naphthol (HL2) (2) was synthesized via condensation of 2-(1H-benzimizadol-2-yl)aniline and respectively salicylaldehyde or naphtylaldehyde. The synthesis of mixed complexes (3)-(6) was realized by reacting ligands HL1 (1) and HL2 (2), copper salt (CuCl2.2H2O) and respectively one equivalent of 2-mercaptobenzothiazole or 2-aminobenzothiazole. The ligands as well as the metal complexes have been identified with multiple spectroscopic techniques. The results data indicate that the copper is linked to ligands via deprotonated phenolic oxygen atom, nitrogen or sulphur atom of co-ligands and the coordination was realized through the azomethine group. X-ray powder diffraction analysis of complexes suggest that posses monoclinic structure for complexes (3) and (4), while complex (5) has orthorhombic structure and rhombohedral structure for complex (6). The in vitro anticancer activities of the different complexes were evaluated and the results revealed an important cytotoxicity of complex (6) against lung human cancer A-549 and very good selectivity with 12.4 values of inhibitory concentration IC 50. The best result was described with complex (4) and present high activities on both A-549 and Caco-2 indicating good selectivity on lung human cancer A-549 and moderate selectivity on colorectal cell line Caco-2 with 10.9 and 15.7 respectively of IC 50.https://ejchem.journals.ekb.eg/article_158582_e41a4a8153ace9aa2887e302734ca5c6.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Effect of the Polymer Structure Diversity on the Eddies Suppression of Basrah Light Crude Oil Turbulent Flow3365337815576210.21608/ejchem.2021.61114.3317ENMahir AsaadJalalDepartment of polymer technology, Polymer research center, University of Basrah, Basrah, Iraq.0000-0002-1748-7930Moayed NaeemKhalafDepartment of Chemistry, College of Science, University of Basrah, Basrah, IraqMouayed AbdulAleeAl-AbdulsayyedDepartment of Chemistry, College of Science, University of Basrah, Basrah, Iraq0000-0001-7465-1939Journal Article20210203Poly(pentaerythritol adipate), poly(pentaerythritol sebacate), and poly(pentaerythritol hexadecandioate) derivatives containing different length alkyl branches were synthesized by two subsequent steps; the reaction of pentaerythritol with (C8-C16) linear aliphatic monocarboxylic acids and then, polymerization of products with (C6-C16) linear aliphatic dicarboxylic acids, using 1% para toluene sulfonic acid as a catalyst. The products were purified and characterized by FTIR, 1H NMR, and 13C NMR spectroscopy. End group analysis was also used as a molecular weight determination technique. The drag-reducing properties of those polymers were investigated in the turbulent flow of Basrah light crude oil using a closed-loop circulation system. Some were found to perform very well DRA and drag reduction efficacy of polymer was further found to be dependent on flowrate, polymer concentration, medium-temperature, and its chemical structure. Also, the effect of the imposed mechanical shear on the polymer stability as a function of time has been investigated using a cylindrical rotator device. It was observed that distance between branch points plays a direct role in contributing to the polymer performance and its mechanical stability.https://ejchem.journals.ekb.eg/article_155762_2b71393649892a92122ea8103b217baf.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Encapsulation of Soy Lecithin Nanoparticles in Gelatin Coating for the Fortification of Gelled Food Products with Phospholipids3379338615454910.21608/ejchem.2021.61610.3333ENAmrEdrisAroma & Flavor Chemistry Department, Food Industries and Nutrition Division, National Research Centre, Cairo, Egypt.0000-0001-8213-0770Journal Article20210207Phospholipids are category of nutrients that are essential for growth and health maintenance. They are commonly supplied from animal-derived foods. However, plant-derived phospholipids like soy lecithin seems also to be potential alternative because they are well received by different category of population who have concerns about animal-derived foods. The purpose of the current investigation is to formulate gelatin-based matrix bearing soy lecithin as a model of gelled food product fortified with plant-based phospholipids. First an aqueous colloidal system containing lecithin nanoparticles is formulated. The average particle size of lecithin was 79.0 nm and its zeta-potential was -49.0 mV. Then, lecithin nanoparticles were encapsulated in gelatin coating using the layer-by-layer electrostatic deposition method. That led to the formation of gelatin-encapsulated-lecithin nanoparticles which has an average particle size 204.0 nm and a zeta-potential +4.0 mV. Upon cooling that system at 4ºC, a hydrogel bearing lecithin nanoparticles is formed. The whole process was evaluated using different techniques in order to verify the encapsulation of lecithin nanoparticles within the gelatin matrix. The physical stability of all formulations before and after encapsulation was monitored during and after storage for 3 months. The concept of this investigation can be useful for fortification of some gelatin-based food products with plant-based phospholipids, which can be used as a dietary supplement for health maintenance and promotion among different populations.https://ejchem.journals.ekb.eg/article_154549_7970432f16d1af5dc258f2e5eb247b1c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Evaluation of Petrophysical and Hydrocarbon Potentiality for the Nubia A, Ras Budran oil field, Gulf of Suez, Egypt.3387340415747110.21608/ejchem.2021.62045.3334ENAhmed GalalElsayedgeological &amp; geophysical engineering dept
faculty of petroleum and mining engineering
suez universityMohamedKassabExploration
Department, Egyptian petroleum research instituteWaleedOsmanPetroleum Eng. &Gas Technology Dept., The British University in Egypt ,(B.U.E)
Geology Dept., Faculty of Pet. & Min. Eng., Suez University, Suez, EgyptJournal Article20210207The present study deals with the Petrophysical Evaluation of Nubia A of Lower Cretaceous age in Nubia Formation, Ras Budran oil field, Gulf of Suez, Egypt. The petrophysical parameters results of Nubia A in Nubia Formation is represented laterally (Iso-parametric maps, such as effective porosity, shale content, net-pay thickness and hydrocarbon saturation maps).A set of well logs has been run for the selected four wells. These wells named (RB-A1, RB-B1, RB-B11 and RB-C1). The minimum suite of logs consisted of gamma ray, density, neutron, and resistivity logs, all the log data are in the form of LAS files.<br /> Nubia Formation is very good reservoir rock in most intervals, where the interpretation of the well logging data indicates that the total porosity ranges from 13.8% to 15%, effective porosity ranges from 13.2% to 15%, shale content ranges between 0.3% to about 2.1%, water saturation from 15.4% to about 52.1%, hydrocarbon saturation ranges from 47.9% to 84.6% and Netpay thickness ranges between 21 ft toabout137.25ft. From Lithological Identification Techniques for Nubia A indicates the presence of mixed lithology has sandstone, shale, dolomite and limestone.<br /> The developments in Ras Budran field for Nubia A towards the central part around RB-B1 well and northwest- southeast, this shown by the increasing of effective porosity and hydrocarbon saturation respectively. There is a good opportunity to drill other Exploratory and development wells to enhance the productivity of the study area because it is containing valuable amount of hydrocarbon accumulation. The best well for this study is RB-A1 has high hydrocarbon saturation 76.2%, effective porosity 13.7% and Net pay thickness137.25 ft.https://ejchem.journals.ekb.eg/article_157471_ee55717377ced2996b45988b18bb09df.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Study of Suggested Chemotherapy Agent of bis ((S) -3-methoxycarbamoyl pentanoate) di chloride bis (ethyl amine) platinum (IV))MPP) using DFT3405341115753610.21608/ejchem.2021.62383.3338ENNasir HamzaKazimDirectorate of Education in Najaf GovernorateLekaa HussainKhadimChemistry Department, College of Education for woman, University of Kufa , IraqJournal Article20210209Abstract<br /> In this paper, we designed the platinum octahedral complex as an anti-cancer drug by applying it to the Gaussian 09W program. The physical properties were calculated using the DFT / B3LYP density function theory for basis sets (LANL2DZ), we also calculated the ultraviolet-visible spectrum (UV), the infrared spectrum (IR), the stability energy, the HOMO and LUMO orbits, the Global properties, and the difference between them and studied the reduction of the octahedral complex to a flat square and its hydrolysis inside the human body, then compared its association with the nitrogenous bases that make up the DNA through nitrogen atom number (N7) and then its association With DNA strand and the results showed that the designed compound achieved high chemical rigidity when linked to methyl. DNA and this indicates its biological effectiveness towards cancer inhibition and compare this result with the well-known treatment against cancer, which is cisplatin, theoretically using the same method and the same basis.https://ejchem.journals.ekb.eg/article_157536_6519d6092d672046afd4758071a83cee.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Uses of some Nano-Sized Organic Wastes to Treat Industrial Wastewater3413342115690910.21608/ejchem.2021.62752.3344ENEmanAbd El-RazikSoils, Water and Environment Res. Inst., Agric. Res. Center, Giza, EgyptAmal M.Abdel-karimPhysical Chemistry department, NRC, Dokki, Giza, Egypt.0000-0001-9210-084xJournal Article20210211Industrial progress led to environmental pollution and one of this pollution is heavy metals which accumulate in water bodies, and this causes a serious health hazard to all living organisms. Chromium is one of the heavy metals that are used in various industries. It is present in wastewater in two toxic forms chromium (III) and chromium (VI). Agricultural byproducts as green tea spoil (GTn) and pomegranate peels (PPn) are used for metal adsorption. Its particle size ranged from 12 to 43 nm investigated by TEM. It is found that, the adsorption of Cr (VI) ions dependent on different parameters such as pH, contact time, adsorbent dose, and particle size. The results showed that the remova1 efficiency of Cr (VI) ions was 99.98 and 98.95% for both GTn and PPn, at pH 7, 210 min contact time, and 1g/100ml dose. The utilization of these sources of agricultural byproducts would solve some disposal problems as well as techniques in using cheaper materials for the adsorption of heavy metals in aqueous wastewater due to its abundantly available, biodegradable, and reuse material.https://ejchem.journals.ekb.eg/article_156909_545039b50c8d9f808901c9416269a209.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701MicroRNA-146a Expression and Serum Interleukin-17 Level as potential biomarkers for Rheumatoid Arthritis3423342915960010.21608/ejchem.2021.62848.3355ENHeba AhmedElmaltfaculty of medicineAmr MahmoudIbrahimfaculty of medicineMina WassefGirgissfaculty of medicine0000-0003-0857-399XJournal Article20210215Small non-coding RNAs are microRNAs (miRNAs) that can play a role in controlling various immune functions. MicroRNA-146a (miRNA-146a) is regarded as an essential element in posttranscriptional gene expression regulator, indicating a possible function in autoimmune diseases. Aim: The aim of the research was to evaluate the expression of miR-146a and Interleukin-17 serum levels as potential markers for rheumatoid arthritis (RA) diagnosis and to investigate its association with the activity of the disease. Methods: This research comprised 60 subjects divided into 30 RA patients and 30 healthy individuals. The rate of erythrocyte sedimentation rate (ESR), anti-cyclic-citrullinated peptide (anti-CCP) antibodies rheumatoid factor (RF), C-reactive protein (CRP) and serum IL-17 level were estimated. Using reverse transcriptase real time polymerase chain reaction quantitative, the relative quantification of miR-146a expression was determined. Results: There are highly pronounced statistical variations was observed between patients and healthy controls, with relative expression of miR-146a, (ESR), CRP, IL-17 and (anti-CC). There are also extremely important statistical differences (p < 0.001) between the various patient subgroups with respect to miR-146a relative expression. IL-17 level in the RA group was higher than in the control group. Positive associations were noticed between the levels of IL-17, ESR, CRP, (anti-CCP) and miR-146a. Conclusion: This study showed that even the expression of miR-146a was highly significant in RA patients, the level of expression was associated with the activity of the disease. Also, the increase in serum IL-17 in patients with RA compared with healthy controls played an important role in the diagnosis of the inflammatory and destructive characteristics of RA.https://ejchem.journals.ekb.eg/article_159600_56a65d880f911062c8505a4fd95cab86.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Cloud Point Extraction Procedure for Preconcentration of Co2+, Ni2+ and Cu2+ from Water and Biological Samples Using a thiosemicarbazone Derivative as a Complexing Agent3431343715882410.21608/ejchem.2021.63390.3360ENEmanErfanChemistry Department, Faculty of Science, Mansoura University, MansouraWael I.MortadaUrology and Nephrology center, Mansoura University
Urology and Nephrology center, Mansoura University0000-0001-7797-0302HalaEl AsmyChemistry department, Faculty of Science, Mansoura UniversityM.M.El-DefrawyChemistry Department, Faculty of Science, Mansoura University, EgyptJournal Article20210216An accurate and simple preconcentration procedure was presented for cloud point extraction of Co2+, Ni2+ and Cu2+ from water, blood and urine samples. The procedure based on complexation of the metal ions with (E)-2-(2,4-dihydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide (DHBPHC) and subsequent extraction into a surfactant-rich phase of Triton X-114. The optimized procedure (50 mL solution; pH 6; 1 × 10–4 mol L-1 of DHBPHC; 0.08% (v/v) Triton X-114) exhibits linear range up to 500 µg L-1 and limit of detection of 0.34, 0.94 and 0.83 µg L-1 for Co2+, Ni2+ and Cu2+, respectively. Most potentially interferants did not impact the extraction process. The procedure was applied for preconcentration and determination of Co2+, Ni2+ and Cu2+ in water, blood and urine by flame atomic absorption spectrometry.https://ejchem.journals.ekb.eg/article_158824_586f72eeffa9c9f842375b25ca5af66b.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701C-Phycocyanin isolated from Microcystis aeruginosa Kützing mitigates renal injury induced by potassium dichromate via toll-like receptor-4 down regulation in rats3439345015960110.21608/ejchem.2021.63657.3362ENAbeerSalamaPharmacology Department, National Research Centre, Dokki, Cairo, 12622, Egypt0000-0001-9870-5583Rehab A.HusseinPharmacognosy Department, National Research Centre, Dokki, Cairo, 12622, EgyptWalaa S. A.MettwallyChemistry of Natural and Microbial Products Department National Research Centre, Dokki, Cairo, 12622, EgyptMohamed S.HelmyMolecular Biology Department, National Research Centre, Dokki, Cairo, 12622, EgyptGamila H.AliWater Pollution Research Department, National Research Centre, Dokki, Cairo, 12622, EgyptJournal Article20210217C-Phycocyanin is among the most promising microalgal derived molecules with an array of pharmacological activities. Toll-like receptors (TLRs) have a vital role in regulating inflammatory response in renal injury. The aim of this study was to evaluate the possible renal therapeutic effect of phycocyanin isolated from Microcystis aeruginosa Kützing harvested from high rate algal pond on potassium dichromate (PD)-induced renal injury in rats. Rats were assigned randomly into: Group I: Normal control group. Group II: Rats injected with a single injection of PD (15 mg/kg; s.c) and served as renal injury group. Group III and IV: Rats received C-phycocyanin (25 & 50 mg/Kg; orally), after PD injection, daily for 7 days. Injection of PD induced a marked renal injury, evidenced by a significant increase in kidney functions and renal contents of malondialdehyde (MDA), tumor necrosis factor–alpha (TNF-α), toll-like receptor 4 (TLR4), heat shock protein 70 (HSP70) and insulin growth factor-1 (IGF-1) In addition PD reduced renal content of reduced glutathione (GSH) and exhibited tubular degeneration and necrosis. C-phycocyanin has renal therapeutic effect against renal injury induced by PD through improving kidney function, down regulation of oxidative stress and TLR4/TNF-α/HSP70 inflammatory pathway as well as modulation of IGF-1.https://ejchem.journals.ekb.eg/article_159601_d6bb7694038123f18d6f709c115eb885.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride3451345615511110.21608/ejchem.2021.43857.2923ENEnas S.ThanoonDepartment of chemistry , college of science
university of Mosul0000-0003-4576-1981Abdussamed M.A.SaeedSection of Basic Sciences, College of Agriculture and Forestry, University of Mosul, Mosul, Iraq0000-0002-8064-7458Journal Article20201007A simple, sensitive and green spectrophotometric method for the determination of metoclopramide hydrochloride (MTC) has been developed. The method is based on the reaction of MTC with p-dimethylaminobenzaldehyde (DAB) in acidic aqueous medium (pH 2) in the presence of anionic surfactant sodium dodecyl sulfate (SDS) to give a yellow colored Schiff’s base with a maximum absorbance at 452 nm. Obedience to Beer’s law is achieved in the concentration range 0.2–18.0 µg ml-1 (5.6×10-7 - 5.1×10-5 mol l-1), with relative error about 1%, relative standard deviation of less than 0.8% and molar absorptivity 3.02×10-4 l mol-1cm-1. The effect of the presence of some common pharmaceutical additives has been investigated. The developed procedure has been successfully applied to the determination of the drug in pharmaceutical formulations.https://ejchem.journals.ekb.eg/article_155111_120da53fa069231779b435f6f7c252dd.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Molecular Docking , Electronica, Structural Characterization of Xanthanolides Derivative A: PM3 Model and ADMET.3457346315691010.21608/ejchem.2021.63311.3364ENZaheda AhmedNajimDepartment of Chemistry, College of Education for Pure Science, Mosul University, Mosul, Iraq0000-0002-1135-3501Journal Article20210217This piece of work is concerned with characterization and studying the overgrown natural products known as Xanthananolide derivatives, by applying quantum mechanical model represented by PM3 (Parametric Method) as a semi-empirical method.<br /> Energy minimization was first carried out. The molecular structure with minimized energy was indemnified and assigned as the most stable conformation.<br /> The molecular orbital energy HOMO and LUMO are determined and they were used as descriptor for the estimation of the reactivity of the nucleophilic cite.Simulation of ADMET (Absorption Distribution Metabolism Excretion Toxicity) was performed related to skin permeability, blood brain barriers (BBB), binding of protein CYP2D6( cytochrome p4502D6), absorption of gastrointestinal binding.<br /> Good oral bioavailability was noted by compound 5.https://ejchem.journals.ekb.eg/article_156910_a920d662f41c5cf2d0e801405a170753.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Antiproliferative Evaluation and Molecular Docking studies of some Sulfonyl-α-L-amino acid Derivatives coupled with Anisamide Scaffold3465347415455210.21608/ejchem.2021.64272.3381ENAlaaeldin M.F.GalalChemistry of Natural Compounds Department, Pharmaceutical
and Drug Industries Research Division, National Research Centre,
33 El Bohouth St. (former El Tahir St.)&mdash;Dokki, Giza P.O. 12622,
Egypt0000-0003-1557-0033KhaledMahmoudPharmacognosy Department
National Research Centre,
El-Behooth St., 12622 Dokki, Giza, Egypt0000-0002-1364-4951Journal Article20210222A series of sulfonyl-α-L-amino acid derivatives coupled with anisamide scaffold, previously synthesized, were evaluated in vitro for their antiproliferative activity against human cell lines namely, Caucasian breast adenocarcinoma (MCF7), hepatocellular carcinoma (HEPG2), Colon cell line (HCT116), and pancreatic cell line (PaCa2) and comparing their results with skin fibroblast cell line (BJ1) as a normal cell line, using MTT cell proliferation assay. The results showed that 2-(4-{[(5-Chloro-2-methoxy-benzoyl)amino]methyl}phenyl)sulfonyl-L-cysteine (5), 2-(4-{[(5-Chloro-2-methoxy-benzoyl)amino]methyl}phen-yl)sulfonyl-L-glutamine (14), and 2-(4-{[(5-Chloro-2-methoxy-benzoyl)amino]methyl}phenyl)sulfonyl-L-tryptophan (18) were the most active molecules against HEPG2, MCF7, and PaCa2 cell lines with IC50 51.9, 54.2, and 59.7 µg/ml respectively. On contrary, 2-(4-{[(5-Chloro-2-methoxy-benzoyl)amino]methyl}phenyl)sulfonyl-L-valine (3) has a high selectivity index for (MCF7) and (PaCa2) cell lines at, IC50 90.9 and 69.5 µg/ml, respectively. Similarly, 2-(4-{[(5-Chloro-2-methoxy-benzoyl)-amino]methyl}phenyl)sulfonyl-L-glycine (1) and 2-(4-{[(5-Chloro-2-methoxy-benzoyl)amino]methyl}phenyl)sulfonyl-L-lysine (10) have cytotoxic selectivity towards (HEPG2) cell line with a high selectivity index with IC50 85.1 and 87.0 µg/ml, respectively. Moreover, a docking study was performed to predict the correct binding geometry for each binder and compare it with its activity.https://ejchem.journals.ekb.eg/article_154552_95732d7a548ca44681c9ba0739426535.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Studies on the Effect of Some Pyrimidine Derivatives on the Corrosion of Iron in 1M Hydrochloric Acid3475348815960310.21608/ejchem.2021.64425.3387ENK. M.Abdel-AzimElectrochemistry Research Laboratory, Chemistry Department, Faculty of Education, Ain Shams
University, Roxy , Cairo, EgyptM.SalehElectrochemistry Research Laboratory, Chemistry Department, Faculty of Education, Ain Shams
University, Roxy , Cairo, EgyptN. S.AbdelshafiElectrochemistry Research Laboratory, Chemistry Department, Faculty of Education, Ain Shams
University, Roxy , Cairo, Egypt.K. F.KhaledElectrochemistry Research Laboratory, Chemistry Department, Faculty of Education, Ain Shams
University, Roxy , Cairo, Egypt.Journal Article20210309The effect of three pyrimidine derivatives namely, 6-amino-3,4-dihydropryimidin-2(1H)-thione (Pyr-3) , ethyl (R)-2-mercapto-4-methyl-6-phenyl-1,6-dihydropyrimidine-5-carboxylate (Pyr-7) and ethyl (R)-6-(4-chlorophenyl)-2-mercapto-4-methyl-1,6- dihydropyrimidine-5-carboxylate (Pyr-9) on the corrosion of iron in 1.0 M HCl in absence and presence of various concentrations ranging from 10-3 to 10-7 M has been studied. Both electrochemical (potentiodynamic, electrochemical impedance spectroscopy and electrochemical frequency modulation) and computational studies (quantum chemical calculations and molecular dynamic simulations) have been used in this study. Electrochemical investigations show the effectiveness of the studied pyrimidine derivatives as corrosion inhibitors. The best inhibition efficiency reached 98% for Pyr-9 at 10-3 M. The studied pyrimidine derivatives were of mixed type inhibitor. Equivalent circuit for the studied system was determined. The studied pyrimidine derivatives follow Langumir adsorption isotherm. Computational study confirms the experimental investigation.https://ejchem.journals.ekb.eg/article_159603_356c2c030d4b6bb85032af4947ee096f.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice3489349815960510.21608/ejchem.2021.64882.3391ENMosabGadNational research centre, Nutrition and food Science Department0000-0003-0322-298XHassanZ. HassounaNutrition and Food Science Department, National Research Centre, 12622, Giza, Egypt.KhaledMahmoudPharmacognosy Department, National Research Centre, 12622, Giza, Egypt.0000-0002-1364-4951Ahmed A.Abd-RabouHormones Department, Medical Research Division, 2Stem Cell Laboratory, Center of Excellence for Advanced Science, National Research Centre, 12622, Giza, Egypt.0000-0002-9875-7591Amal S.Abdel-AzeemNutrition and Food Science Department, National Research Centre, 12622, Giza, Egypt.Amany M.HegazyNutrition and Food Science Department, National Research Centre, 12622, Giza, EgyptMohamed S.Abdel- LattifeDepartment of Biochemistry, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.Fouad A.AhmedDepartment of Biochemistry, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.Journal Article20210224The objective of this study was to evaluate the potential toxicity of methanolic extracts of Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens). Single oral dosage was administered to male mice at increasing concentrations of 100, 250,500,1000 and 2000 mg/kg body weight to assess the median LD50, which causes the death of 50% (one half) of the mice. Blood samples were collected at the end of the 14 day toxicological trial for the liver and kidney function tests. The results showed that the LD50 of P. roxburghii was 1708.3 mg/ kg body weight and of N. graveolens 1562.5 mg/kg body weight. The acute toxicity had detrimental effects on the liver and kidney function. Based on this finding, a second trial was designed, and the mice were administered day after day intragastrically one tenth (1/10) the LD50 of each plant extract for a whole month. At the termination of the 30-day trial, blood samples and organs were collected for liver and kidney function tests. The long-term administration of 1/10 the LD50 dosages had no significant adverse effects neither on the liver and kidney functions nor on the histopathological examination. In conclusion, further studies are warranted to determine the potential application of these plant as natural therapeutic products.https://ejchem.journals.ekb.eg/article_159605_cfe3e16979ece5587855517e7c5416dd.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701GC/MS-Based Metabolomics Profiling Approach and Determination of Ameliorative effect of Chiliadenus montanus extract towards CCl4 induced Hepatotoxicity in Albino Rats3499351015576410.21608/ejchem.2021.65354.3401ENMona AbdullahMousaDepartment of Phytochemistry and Plant Systematics,Division of Pharmaceutical Industries,National Research Center, El Buhouth st., Dokki
Dokki, Cairo, EgyptAli MohamedElhagrasiDepartment of Phytochemistry and Plant Systematics,Division of Pharmaceutical Industries,National Research Center, El Buhouth st., Dokki
Dokki, Cairo, EgyptAlaaeldin Sayed SayedEwaseMinistry of Environment , Nature Conservation Sector, Cairo, Egypt.Abdelmohsen M.SolimanTherapeutic Chemistry dept.
National Research Centre, Dokki, Giza, Egypt0000-0001-8816-5309Sahar AwadallahHusseinHead of department of Phytochemistry and Plant Systematics,Division of Pharmaceutical Industries,National Research Center, El Buhouth st., Dokki
Dokki, Cairo, Egypt0000-0002-6305-508XJournal Article20210227The current study aimed to evaluate the GC/MS profiling of Chiliadenus montanus leaves extract which consists of 48 compounds, nine of them are major and represented 52.55 % from the total peak areas. The ameliorative effect towards the CCl4-induced hepatotoxicity in male Wistar rats through measuring certain biochemical parameters content in the liver were analyzed. CCl4 diluted 1:9 (v/v) in olive oil was injected intraperitoneally followed by oral administration of methanolic plant extract (200 mg/kg body weight).<br /> The CCl4-treated rats showed a significant decline in the studied hematological parameters, the serum levels of high-density lipoprotein (HDL), albumin (A) as well as the hepatic levels of glutathione (GSH) and activities of catalase (CAT), superoxide dismutase (SOD) , glutathione reductase (GR), elevation in the levels of total lipids (TL), triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), globulin (G), total bilirubin (TBil) , alanine and aspartate aminotransferase and alkaline phosphatase (ALAT and ASAT, ALP) and the hepatic levels of malondialdehyde (MDA). In contrast, the administration of methanol extract, notably improved all the studied parameters. This study showed that CCl4 administration to Wistar rats, at a high dose level, could induce a hepatic injury in addition to certain hematologic and metabolic alterations. The work was extended to examine tissue histopathology. <br /> In conclusion, C. montanus leaves methanol extract, resulted in an attractive candidate for ameliorating of hepatotoxicity induced by CCl4 through scavenging free radicals, improved liver functions, and normalizing the liver histopathological architecture. <br /> Yet, the treatment with methanol extract could ameliorate these alterations via their antioxidative effect. Further studies are required in order to identify the molecules responsible of the pharmacological activities.https://ejchem.journals.ekb.eg/article_155764_e88db844d7874a585845873996aa6f09.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Cellulases and animal feed production by solid-state fermentation by Aspergillus fumigatus NRCF-122 mutant3511352015690810.21608/ejchem.2021.62744.3347ENMohamedFadelMicrobial Chemistry Department, Genetic Engineering and Biotechnology Research Division. National Research Centre, Dokki, Giza. Egypt.Ahmed A.HamedMicrobial Chemistry Department, Genetic Engineering and Biotechnology Research Division. National Research Centre, Dokki, Giza. Egypt.0000-0002-9997-9284Ahmed M.Abd-ElazizMolecular biology department, Genetic Engineering and Biotechnology, and Biotechnology Research Division. National Research Centre, Dokki, Giza. Egypt.0000-0001-6720-484xManal M.E.GhanemMolecular biology department, Genetic Engineering and Biotechnology, and Biotechnology Research Division. National Research Centre, Dokki, Giza. Egypt.Amira M.RoshdyMicrobial Chemistry Department, Genetic Engineering and Biotechnology Research Division. National Research Centre, Dokki, Giza. Egypt.0000-0001-6809-9949Journal Article20210212A high cellulase-producing fungus was isolated from agricultural waste compost, purified, identified genetically as Aspergillus fumigatus NRCF-122 (accession no. MT318341), and improved by UV-irradiation for cellulase production (named as A. fumigatus mutant-17). Optimal cellulase production conditions were studied using sugar beet pulp “SBP” as the substrate of solid-state fermentation "SSF" technique. The optimal conditions were: initial moisture content ratio (1:2 w/v), incubation temperature (30°C), initial pH of solid culture (10), incubation period (4 days), aeration area (1:100 ratio ((1%)), SBP substrate weight : flask volume of moistened SBP in a 250 mL Erlenmeyer flask, fungal inoculum (seeding) culture age (3 days) and inoculum size (20%, v/w). Studies were also involved the effect of different nitrogen sources where urea is the best nitrogen source for cellulase production. Concerning the application of bioethanol production from yeast, using rice straw cellulose as a source of fermentable reducing sugars), the lingo-cellulosic waste rice straw was first pretreated (with NaOH 1.5%) to reduce crystallinity of cellulose & removing lignin and other inhibitors, enhancing the subsequent process (saccharification) of rice straw cellulose. Then, its cellulose was saccharified enzymatically by cellulases (produced from SBP as substrate (under SSF condition) as substrate under the optimum conditions) resulting in reducing sugars. one of the largest livestock production operating costs is the feed bill. In our study we evaluated the resulted crude protein content of the fermented SBP and the results declared that, the total digest nutrient (TDN) and gross energy performance were increased, where as crude fiber, acid detergent fiber ADF & neutral detergent fiber NDF were decreased, thereby upgrading the feed quality of biologically treated SBP.https://ejchem.journals.ekb.eg/article_156908_d29d7cbe4f7a61c7b49ee7162e4f3830.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Influence of Extract Derived Cell Cultures of Broccoli against Osteoporosis in Ovariectomized Rats3521353915960410.21608/ejchem.2021.64803.3419ENAbeerSalamaDepartment of Pharmacology, National Research Centre, Dokki, 12622, Cairo, Egypt0000-0001-9870-5583Mohamed F.AbdelhameedDepartment of Pharmacology, National Research Centre, Dokki, 12622, Cairo, Egypt0000-0001-6100-6498SamyMostafaDepartment of Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622, Cairo, EgyptSomaia A.NadaDepartment of Pharmacology, National Research Centre, Dokki, 12622, Cairo, Egypt0000-0003-2631-5089Hussein STahaDepartment of Plant Biotechnology, National Research Centre, Dokki, 12622, Cairo, EgyptAsmaa AAmerDepartment of Pharmacognosy, National Research Centre, Dokki, 12622, Cairo, Egypt0000-0001-7208-3288Journal Article20210304This study was conducted to enhance broccoli secondary metabolites; using plant biotechnology techniques and tissue culture as well as to evaluate the therapeutic effect of broccoli extract against osteoporosis in ovariectomized (OVX) rats. Cell culture technique was implemented in order to achieve and produce polyphenols from leaf explants of broccoli. The high-performance liquid chromatography (HPLC) technique was used to evaluate the polyphenolic profiles of ethanolic extracts for cell cultures compared to the dried inflorescences of broccoli (cultivated plant). However, total phenol and flavonoid contents were determined by spectrophotometric technique. Induction of osteoporosis was performed via ovarectomy operation where rats were divided into 5 groups (10 rats each). Group 1: Sham operated control group and the remaining rats were ovariectomized for 12 weeks to produce osteoporosis model. Group 2: Ovariectomized osteoporotic positive control group. Groups 3-5: Ovariectomized rat daily received 17‐β‐estradiol (10 µg/kg), broccoli cell suspension culture ethanol extracts (300 & 600 mg/kg) orally. The obtained results showed that Murashige and Skoog basal nutrient medium (MS) fortified with 2.25 µM of 2,4-Dichlorophenoxyacetic acid (2,4-D) and 0.55 µM of kinetin (kin.) showed the best medium for calli production. Addition of methionine enhanced polyphenolic production in cell suspension culture which was identified by HPLC. Administration of broccoli cell suspension extract elevated the uterine weight, high density lipoprotein-cholesterol and estradiol 2 (E2) serum levels and reduced serum levels of lipid profile, liver and kidney functions, osteocalcin and total procollagen type 1 N-terminal propeptide (TPINP). In conclusion, broccoli may be a promising sources of secondary metabolites; polyphenol contents and flavonoids for treatment of bone loss and cell damage in osteoporosis.https://ejchem.journals.ekb.eg/article_159604_c6ec2989fc7f71e363fd6ce468d693d7.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Terbium Bipyridyl Complex as a Photo Probe for the Determination of Carbohydrate Antigen CA15.3 in Different Breast Cancer Patient Samples3541354615726310.21608/ejchem.2021.66294.3421ENM. S.AttiaChemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt.A. O.YoussefChemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt.M.GomaChemistry Department, Faculty of Science, Aswan University, Aswan, EgyptT.IbrahimChemistry Department, Faculty of Science, Aswan University, Aswan, EgyptJournal Article20210305A novel, simple, sensitive and selective spectrofluorimetric method has been developed for the assessment of Carbohydrate Antigen (CA 15.3) in serum samples of breast cancer patients by using photo probe Tb-Bipyridyl (Tb-Bipy) complex. The determination method Based on the quenching of the luminescence intensity of Tb-Bipy complex by different concentrations of CA 15-3 in acetonitrile at pH 8.0 and λex = 340 nm. The quenching of luminescence intensity Tb-Bipy complex especially the electrical band at λem = 545 nm is typically used for determining the Carbohydrate Antigen (CA 15.3) in different body fluids. The dynamic range which is found for the assessment of Carbohydrate Antigen (CA 15.3) concentration is 0.1-15.4 U mL-1, and the limit of detection (LOD) and quantitation limit of detection (LOQ) are (0.109 and 0.57) U mL-1, respectively. This method was practical, simple and relatively free from interference effect. It was successfully applied to measure Carbohydrate Antigen (CA 15.3) in samples of human serum and from this method we can assess some biomarkers of cancer related diseases in human body.https://ejchem.journals.ekb.eg/article_157263_5b73ceac8be45e6c481ce291c2807459.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Preconcentration and spectrophotometric determination of Fe(III) by cloud point extraction using Zincon as complexing agent3547355317076710.21608/ejchem.2021.68424.3496ENSara El SayedMohamedAnalytical chemistry, faculty of science, mansoura universityWaelMortadaUrology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptWeamAbo ElmaetyAnalytical chemistry, faculty of science, mansoura universityMagdiKhalifaAnalytical chemistry, faculty of science, mansoura universityJournal Article20210318A cloud point extraction (CPE) process was described for the separation and spectrophotometric analysis of Fe(III) in different water samples and blood as chelating agent. The complexation reaction between Fe(III) and Zincon was elaborated at pH 5.0 using acetate buffer and the complex was quantitatively recovered in a mixed micelle system composed of cethyltri methyl ammonium bromide (CTAB) and Triton X-114. This reaction was carried out at room temperature in the presence of 0.05 mol L-1 Na2SO4 as salting-out electrolyte. The linearity was up to 1000 µg L-1. The preconcentration factor was 50. The precision (as relative standard deviation) and the limit of detection were 2.5% and 3.1 µg L-1, respectively. The proposed procedure was used for the spectrophotometric detection of Fe(III) in water and blood samples and the data were statistically comparable to those achieved using ICP-OES technique.https://ejchem.journals.ekb.eg/article_170767_e0df4952b25d06e76f62819600485b74.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, Spectral, Thermal and Biological Studies of Some Transition and Inner Transition Schiff base Metal Complexes3555357116703810.21608/ejchem.2021.71817.3578ENEmanKhalilChemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt0000-0002-3761-9582WalaaMahmoudChemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt0000-0001-9187-4325MaherEldessoukyChemistry Department, Faculty of Science, Cairo University, Giza, 12613, EgyptGehadMohamedChemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt0000-0002-1525-5271Journal Article20210410The new bidentate Schiff base ligand (L) named N1-(diphenylmethylene)naphthalene-1,8-diamine was prepared by the condensation reaction of benzophenone and 1,8-naphthylenediamine. The complexes with Mn(II), Ni(II), Zn(II), La(III), Er(III), and Yb(III) metal ions were prepared and characterized by using elemental analyses (C, H, N and M), FT-IR, 1H NMR, molar conductivity, magnetic moment, UV-Vis, mass and scanning electron microscope (SEM). The temperatures of decomposition of the Schiff base ligand and metal complexes were investigated using thermal analyses. The metal complexes were found to have the formulae [M(L)(H2O)3Cl]Cl.nH2O (M = Mn(II) (n = 4); Ni(II) (n = 2))], [Zn(L)(H2O)2Cl2] and [M(L)(H2O)2Cl2]Cl (M = La(III), Er(III) and Yb(III)) according to the elemental analyses data. The geometrical structure of all complexes was found to be octahedral. The molar conductivity of the complexes in DMF indicated the electrolytic nature of all complexes except Zn(II) complex was non-electrolyte. From the spectroscopic data, the Schiff base ligand acts as NN-bidentate ligand. The biological and anticancer activities of the Schiff base ligand and its complexes were investigated against two bacterial strains, two fungal strains and breast cancer cell line (MCF-7). Docking studies were performed to study the possible interaction between the Schiff base ligand with the active sites of the 3HB5 and 5JPE receptors.https://ejchem.journals.ekb.eg/article_167038_eb6eb18e868459785734ea05b7bb2abd.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701In vitro Cytotoxicity, Antimicrobial, Antioxidant Activities and HPLC Finger Print Analyses of the Extracts of Ceiba insignis Leaves Growing in Egypt3573358616699210.21608/ejchem.2021.73023.3618ENAbdel-Wanes AnterAbdel-AzizTheodor Bilharz Research InstituteMonaAbdel-MotagalyTheodor Bilharz Research InstituteMagda AhmedAbdallahdepartment of chemistry, faculty of science, cairo universityRasha ShaabanShaabanBiochemistry department, TBRINadia SayedOsmanmedicinal chemistry, TBRINehal MElwanchemistry department, faculty of science, cairo universityJournal Article20210418Polyphenols - rich plants can be used to reduce health disorder resulting from cancer and infectious diseases. Methodology: Different solvent extracts of Ceiba insignis leaves were evaluated for their in vitro cytotoxic, antimicrobial, and antioxidant activities, while their chemical profiles were investigated via high‑performance liquid-chromatography (HPLC) fingerprint analyses. Results: Showed that methanol, butanol, and dichloromethane extracts of Ceiba insignis leaves exhibited a moderate cytotoxicity against HepG2 with IC50 values of 98.54, 75.38, 40.71 µg/ml respectiviely, while petroleum ether and water exhibited weak activity with IC50 values of 118.15 and 170.03 µg/ml respectively and very weak activity was recorded with ethyl acetate extract with IC50 value of 924.05µg. Moreover, methanol, dichloromethane, petroleum ether, and ethyl acetate exhibited strong antimicrobial activities with inhibition zones (20-25 mm), (15-30 mm), (14-16 mm), and (16-28 mm) respectively, while butanol and water exhibited low to moderate activity with inhibition zones (0-18 mm), and (0-16 mm) respectively. On the other side, strong DPPH antioxidant scavenging activity was recorded within petroleum ether extract with IC50 (24.72 μg/ml), while the least antioxidant activity was recorded within ethyl acetate with IC50 (97.50 μg/ml). HPLC finger-print analyses revealed the presence of major compounds; syringic acid in dichloromethane extract, gallic acid, chlorogenic acid & syringic acid in ethyl acetate extract, and naringenin & gallic acid in methanol, butanol and water extracts, this finding provides an insight into the usage of the tested species as a source of naturally occurring antioxidant, cytotoxic and antimicrobial agents.https://ejchem.journals.ekb.eg/article_166992_dbf7f06fdb8e19a90fcf0bb47a436034.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Halogens Substitution Effects on Electronic and Spectral Properties of Carbon Nanotube Molecules studying with the DFT method3587359517017210.21608/ejchem.2021.74728.3680ENRajaaMohammadDepartment of Physics , College of Science, University of Kerbala, Karbala, Iraq.SabeehJassimDepartment of Physics, College of Science, University of Misan, Misan, Iraq.0000-0002-2347-6314LumaAhmedDepartment of chemistry, College of science, University of Kerbala0000-0002-0338-6637Journal Article20210501The carbon nanotubes (CNTs) in a zigzag (4, 0) shape before and after substituted with F, Cl, and Br atoms were used as a basic computer model depending on the Quantum Espresso package DFT process (in the present work. This method demonstrated that the electronic structure, bandgap, total energy, FTIR spectrum, Raman spectrum, and depolarization spectrum can all being calculated. The simulated results are discovered that the increase in impurity atom size from F to Br as donor groups on nanotubes reduce the energy gaps from 0.959 eV to 0.674 eV, the ionization potentials from 6.088 eV to 5.729 eV, the electron affinities from 5.129 eV to 5.054 eV, and the firm energies from 5.609 eV to 5.392 eV. As a result, these substituted compounds have a high activity to act as a catalyst with broad absorption bands of the solar spectrum in the following order: Br+CNTs > Cl+CNTs > F+CNTs > CNT. This behavior will provide a better output for the solar cells and photovoltaic devices. The increment in HOMO, LUMO, and total energy magnitudes with increasing the impurity atom size from F to Br is given maximum changes, decreases band gaps, and elevated entropy values because of elevating in random.https://ejchem.journals.ekb.eg/article_170172_b640e2e50eaa6b9b79bdb851517af13c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Produced Water Treatment Design Methods in the Gas Plant: Optimization and Controlling3597360315511210.21608/ejchem.2021.56149.3205ENEbrahiem EsmailEbrahiemChem. Eng. Dept., Faaculty of Eng., Minia university. Minia, Egypt.Abdelaziz ANoamanChemical Engineering Department, Faculty of Engineering, Minia University, Minia, EgyptMoustapha IMansourChemical Engineering Department, Faculty of Engineering, Alexandria University, Alexandria 21544, Egypt.Mohamed SAlmutairiMinistry of Electricity and Water, Kuwait, Kuwait, P.O.12010Journal Article20210101Oil and gas industry produces a huge volume of produced water that contains hydrocarbons, heavy metals, and other pollutants. In the oil and gas industry, produced water, treatment, and management represent a growing challenge. Increasing the oil and gas industry activities, the production of produced water is increased all productions areas all over the world. Its treatment for reuse, management, and disposal represents a significant challenge from an environmental perspective. It is estimated that for every 1 barrel of oil produced, there are 8 to 10 barrels of produced water recovered. In this paper, a comparison of the different techniques for the primary and secondary produced water treatment that are widely applied in industry was investigated to choose the best applicable technology to achieve the required treated produced water specification in the gas project. A technical and economic comparison were conducted. It has been found that de-oiling hydrocyclone followed by induced gas flotation unit is the best choice.https://ejchem.journals.ekb.eg/article_155112_21be7da80b0b9fa531ce0f84342f85c7.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Presenting Shape Memory Polymers SMP and some Reinforcement materials for gaps filling in Archaeological Bones3605361416527210.21608/ejchem.2021.69586.3526ENSamiaaGaballahMA student in Conservation, Faculty of Archaeology, Cairo University, Giza, EgyptMehrez E.El-NagarTextile Research Division, National Research Center (Affiliation ID: 60014618), Dokki, Cairo, EgyptGomaaAbdel-MaksoudConservation Department, Faculty of Archaeology, Cairo University, Giza, EgyptAhmed M.YoussefPackaging Materials Department, National Research Centre, 33 El-Bohouth St. (formerly El-Tahrir
St.), Dokki, P.O.12622, Giza, Egypt.Journal Article20210326Mummies and bones are potentially materials since they retain the memories of the ancients and revealed the degree of their greatness. Bones are organic materials that include proteins like collagen, minerals including calcium hydroxyapatite, as well as other substances. By assisting with other factors (physical or chemical), the essence of bone allows microorganisms as well as insects to assault it. The aspects that can be formed as a result of this degradation process are known as holes. Gaps are also a challenging task for bone artifacts, especially in the excavation area. This current article review focused on the factors that create holes. In addition to the survey about the shape memory polymers aerogels (SMPA) and reinforcement materials which can be utilized to adapt to the old bones, as well as improvement materials to render certain old reinforced polymers provide shape memory behavior. The examination and investigation analysis tools which could be utilized for evaluating the treated bones with certain shape memory polymers aerogels were also addressed in the article review.https://ejchem.journals.ekb.eg/article_165272_4a41cd116a7fac9ad92123018d83ff43.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Implication of Aluminum in Exerting Some Health Disorders Among Exposed Workers3615362216489010.21608/ejchem.2021.69699.3531ENSafiaBeshirProfessor of Environmental Health and clinical pathology. Environmental and Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, EgyptWeamShaheenAssociate Professor of environmental health, Environmental and Occupational medicine department, NRCEmanEL-tahlawyProfessor of Public Health. Environmental and Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, Egypt.Journal Article20210327The present study aimed to evaluate implication of aluminum in exerting male reproductive and thyroid hormonal disorders and lipid profile changes among aluminum workers. Cross-sectional study was carried on 56 male aluminum workers in aluminum welding factory. Aluminum dust level was measured and questionnaire was conducted for all participants. Urinary aluminum level, serum total cholesterol, triglycerides, high density lipoprotein, high sensitive c-reactive protein, apolipoprotein- E, total antioxidant capacity, malondialdehyde, luteinizing hormone, follicle stimulating hormone, testosterone,17-beta-estradiol, free triiodothyronine, free thyroxin and thyroid stimulating hormone were measured in both groups. Aluminum dust mean concentration was 1.6 ± 0.3 mg/m3 in the present study. Urinary aluminum, serum triglycerides, very low density lipoprotein cholesterol, high sensitive C-reactive protein and malondialdehyde levels were significantly higher while total antioxidant capacity was significantly lower among the exposed workers compared to controls. Serum follicle stimulating hormone and free triiodothyronine were significantly higher while free thyroxin was significantly lower in the exposed group compared to controls. No effect of smoking on all measured parameters was reported except for luteinizing hormone. Negative correlation was found between duration of exposure and 17-beta-estradiol. Urinary aluminum level was negatively correlated with total antioxidant capacity on one side and positively correlated with malondialdehyde on other side. Induction of oxidative stress and inflammation might be the possible mode of action by which aluminum exert male reproductive hormonal disorders and lipid profile changes. Aluminum may disrupt thyroid hormones. Pro inflammatory effect of aluminum was verified by the inflammatory markers.https://ejchem.journals.ekb.eg/article_164890_4658f327e2797ce74a8545b0a071c009.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, Characterization, scaling up and use of Calcium Carbonate Nanoparticles to prepare nanoporous PVC film3623363415687810.21608/ejchem.2021.49234.3012ENAhamed IAbd-ElhamidUniversities and Research Centres DistrictH. F.AlyHot Laboratories Centre, Atomic Energy Authority,13759, EgyptHesham M.A.SolimanAdvanced Technology and New Materials Research Institute, City of Scientific Research and Technology Applications, P. O. Box 21934, Alexandria, Egypt0000-0003-4000-1297M. A.AklFaculty of Science, Mansoura University.Aref M.EAbd ELRahmannanotechnology depaetmentTamer AbdElrazikCity of Scientific Research and technological applications (SRTA)0000-0002-6203-7488Journal Article20201114CaCO3 nanoparticles were synthesized from CaCl2 and Na2CO3 using a new, fast and straightforward technique. Factors affecting on the particle size such as the concentration of Ca2+ and CO32-, PEG weight dissolved in Ca2+ solution, flow rate, temperature, media type, PEG weight dissolved in the used medium, the concentration of CO32-, stirring speed, medium volume and additive dissolved within Ca2+ solution were investigated. The obtained particles were characterized by SEM, XRD, EDS, IR and TGA. The characterization clarified that the particles prepared were spherical with a size range of 19-30 nm, ultra-pure, and calcite. Moreover, the preparation system was redesigned to be a continuous preparation system. The histogram showed that the CaCO3 nanoparticles obtained were homogenous in size (30 nm). Finally, the obtained nanoparticles were utilized in the preparation of nanoporous PVC film with pores size range 80-120nmhttps://ejchem.journals.ekb.eg/article_156878_a733b3a7fed4229d433a0b2aacbfead1.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Chemical Modification and Characterization of Chitosan for Pharmaceutical Applications3635364915833910.21608/ejchem.2021.61809.3331ENMohammed A.AlmuallaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Basra University, Basra, IraqMazin N.MosaDepartment of pharmaceutical chemistry, College of Pharmacy, Basra University, Basra, Iraq.0000-0001-8092-7428MohammedSattarDepartment of Pharmaceutics, College of Pharmacy, University of Basrah, Basrah, IraqJournal Article20210206Nine crosslinked chitosan derivatives (CLCS) were prepared using three different types of crosslinkers: glutaraldehyde, glyoxal and terephthaldehyde. The prepared CLCS were used to control the acyclovir (ACV) release in order to improve its oral bioavailability. The CLCS were prepared by Schiff based reaction and characterized by means of infrared spectroscopy (FTIR), x-ray diffraction measurements, thermogravimetric inspection, differential scanning calorimetry, and scanning electron microscopy (SEM). Establishment of an imine (C=N) bond was evidenced in FTIR. Compared to raw chitosan, the crosslinked chitosan derivatives showed more amorphous structure and exhibited more water holding capacity that increased with raising the crosslinking percent. In SEM, the CLCS demonstrated areas with rough surfaces and grooves that did not present in the smooth chitosan surface. The difference in swelling degree with varying crosslinker amount was also examined. The crosslinked chitosan displayed less swelling and the degree of swelling decreased with increasing the density of crosslinking agent. The CLCS investigated in controlling the release of acyclovir by being incorporated with ACV in granules formulations. In vitro drug release results exhibited sustained release of ACV affected by the type and percent of crosslinker.https://ejchem.journals.ekb.eg/article_158339_6fbd9e4d30b668ace972c30691be51e5.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Structural Characterization and Gamma-Ray Shielding- Parameters of Some Phosphate Glasses Containing By-Pass Cement Dust and Barium Oxide3651365815576110.21608/ejchem.2021.43013.2884ENRagbGasserPhysics department, Faculty of Science, Al-Azhar University, Cairo, EgyptOsamaYassinPhysics department, Faculty of Science, Al-Azhar University, Cairo, EgyptSayedM.SalemPhysics department, Faculty of Science, Al-Azhar University, Cairo, EgyptJournal Article20200921By-Pass Cement Dust, as an industrial cement waste, was used to prepare some gamma-ray shielding glasses aiming to protect people and environment from hazard radiations, some phosphate glasses containing different amounts of by-pass cement dust have been prepared by the melt quenching method. The selected molecular composition was [(100-x) % P2O5 - (x) % By-Pass Cement Dust (where x=30,35,…,60)] in steps of five. The obtained experimental density and molar volume values were inspected and were then compared with those obtained empirically for the close packed structure of the corresponding compounds. These comparisons evidenced the short-range order and randomness character of the studied samples. From the IR analysis, different phosphate speeches appeared in the glass networks, as well as some silicate groups appeared in the spectra of all samples due to the presence of considerable amount of SiO2 in by-puss cement dust. Also, the present CaO act to increase Q2 and Q1 species as well as to increase the non-bridge oxygen, The tetrahedral are classified using the Qi terminology .where i represent the number of bridging oxygen's per tetrahedron It appeared also that, as by-pass cement dust was increased, the intensities of O-H and H-O-H groups decreased which indicated that CaO (the major constituent of by-pass cement dust) decreases the absorption of water and strengthening the studied samples. The suitability of such glasses to act as gamma-ray shielding materials was also examined and a correlation between the chemical composition (By-Pass Cement Dust content) and gamma-ray attenuation behavior was established.https://ejchem.journals.ekb.eg/article_155761_29d8866103e7e67d0a11a0dfc7701273.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents3659366417763710.21608/ejchem.2021.79840.3931ENSilkySethySMAS, KR Mangalam University, Gurugram, HaryanaSudip KumarMandalDr. B. C. Roy College of Pharmacy and A.H.S., Durgapur-713206, West Bengal, Indiaorcid.org/0000-0003-Ewies FawzyEwiesOrganometallic and Organometalloid Chemistry, Chemical Industries Division, National Research Centre0000-0002-4832-5766NeerupmaDhimanAmity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201303, IndiaArunGargSMAS, KR Mangalam University, Gurugram, HaryanaJournal Article20210609A substituted benzimidazole and benzindazole derivatives had been synthesized having antihypertensive activity through antagonizing the angiotensin II (Ang II) receptors. The in vivo antihypertensive activity of the compounds was done with acute renal hypertension model. Two compounds TG 1 and TG 3 were found to have antihypertensive activity comparable to Telmisartan which is a prototype for Angiotensin II receptor antagonists class of drugs.In an antihypertensive study the compounds TG 1, TG 2 and TG 3 had systolic blood pressures of 147.2 mm/Hg, 168.2 mm/Hg, and 126.3 mm/Hg, respectively. This systolic blood pressure was lower than the disease control vehicle-treated rodents, which had a systolic blood pressure of 167.2 mm/Hg. The diastolic blood pressure was 119.7 mm/Hg, 124.7 mm/Hg and 88.83 mm/Hg, respectively and that of the disease control vehicle-treated rodents was 122.3 mm/Hg. TG 3 had comparable decrease in the MABP to Telmisartan. These encouraging results make compound TG 3 effective anti-hypertensive drug candidate and worthy of further investigation.https://ejchem.journals.ekb.eg/article_177637_499375a0ebd5da7eaaf6aa3c44d0992d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Improving the Physical Properties of Polyvinyl Alcohol (PVA)-Melanin Doping3665367015391210.21608/ejchem.2021.46441.3061ENMagdy M. GhannamGhannamCairo University, Faculty of Science, Biophysics Department, Egypt,0000-0001-6596-161XBadreeahAwadKing Saud University, College of Science, Physics & Astronomy Dept.,11451Riyadh, Kingdom Saudi ArabiaMohammed SAl-AyedKing Saud University, College of Science, Physics & Astronomy Dept.,11451Riyadh, Kingdom Saudi ArabiaAmany A.AlyCairo University, Faculty of Science, Biophysics Department, Egypt,26312092102165Journal Article20201224The Polyvinyl alcohol (PVA) is an artificial polymer that used in many medical applications but it has a few disadvantages that can overcome with the addition of chemical compounds. <br /> The present study aimed to investigate the efficacy of melanin to improvement the properties biopolymer PVA by doping with of melanin and reinforce the PVA electrical, optical and mechanical properties to prevent it from deformation with time or temperature. In the present work, dielectric relaxation and spectrophotometric techniques were used to characterize the biopolymer PVA doped melanin of different concentration. Reduction of dielectric constant of PVA accompanied with increased in conductivity with the doped melanin concentration. Moreover, relaxation times dropped with an increase of melanin content in PVA. A small shift in Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy of PVA due to increasing the concentration of melanin that caused to increase OH in PVA. A behavior can be used in electronic industries and medical applications.https://ejchem.journals.ekb.eg/article_153912_17dbae0252175a72e3701c1a81226657.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Determining Cadmium Activities and Predicting Solid- Phases Which Control Its solubility in the Soil irrigated with Sewage Water, in Egypt3671367915690710.21608/ejchem.2021.61677.3332ENRababOmerSoils, Water and Environmental Research Institute, Agricultural Research Center, Giza, EgyptSamirEl-gendiSoils, Water and Environmental Research Institute, Agricultural Research Center, Giza, EgyptGamalEl-SayedFaculty of Science, Benha University, Benha, EgyptJournal Article20210208Abstract<br /> The present study included determination of the active portion of Cadmium and predicting its possible solid phases which controlling its activities in sludge amended soils <br /> The results showed that the measured Cd2+activities (using the competitive chelation method) increased with the prolonged use of sewage effluent water in irrigation. As shown from the Table (3) increased Cd2+activity by 9.94 folds than the control soil sample. Furthermore, the results were negatively correlated with pH values (r= 0.81). <br /> Also, the present data clearly show that the tested remedial materials with the three rates of amending (1, 2, and 3% w/w) had great influences on the values of Cd activities. The obtained Cd activities were (4.65006E-09 and 6.89868E-09), (3.7353E-09 and 6.00091E-09), and (4.61439E-09 and 5.93551E-09) in C1, C2, and C3 Zero valent iron- and Rock phosphate amended soil, respectively.<br /> Plotting the determined Cd activities of the tested soil samples on the constructed stability diagrams of the various cadmium minerals indicated that the obtained values of Cd using the competitive chelation method, were lie below the diagrams of the constructed Cd minerals, Suggesting that there are possibility of other minerals could controlling the solubility of Cd in sewage effluent irrigated soil at Egypt.https://ejchem.journals.ekb.eg/article_156907_a510406bfd5f01e73f025140f211c406.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis and Thermoluminescence of Novel Ag3PO4:Ba2+ Nanophosphor as Gamma Radiations Detector3681369015706510.21608/ejchem.2021.62097.3335ENA.El-AdawyPhysics Department, Faculty of Science, Menoufia University, EgyptA.HusseinPhysics Department, Faculty of Science, Menoufia University, EgyptE.R.ShehaNuclear physics department, Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, EgyptS.Abdel-SamadNuclear physics department, Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, EgyptAhmad A.HassanMetallurgy department, Nuclear Research Center, Atomic Energy Authority, Egypt.M.Al-AbyadNuclear physics department, Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, EgyptJournal Article20210208Ba<sup>2+</sup> activated Ag<sub>3</sub>PO<sub>4</sub> (APB6) orthophosphate as novel synthetic nanophosphor material were prepared using different impurity concentrations (1, 3, 5, 6 and 7 wt%) of BaCl2 salt. Coprecipitation method was used in preparation. The prepared nanophosphors were characterized via X-Ray Diffraction (XRD) and High-Resolution Transmission Electron Microscopy (HR-TEM) and the results confirmed the existence of nanoparticles. The thermoluminescence (TL) properties of the samples were extensively studied, where the APB6 sample with 6 wt% Ba2+ showed considerable TL characteristics. All the studied samples were subjected to optimum thermal annealing of 500oC for 1h and a heating rate of 5oC/s was applied. The TL response of APB6 nanophosphor exhibited the highest value in comparison with that of other compositions. In addition, APB6 sample revealed a good linearity of TL response within the gamma rat doses between 15 and 100 Gy, where a linear response is obtained with .0.9925 correlation coefficient. It also showed relationally low rate of fading of about 26% within a 50 days of storage. These good characteristics make the new prepared APB6 phosphor to be highly considered as a new potential TL dosimeter and can efficiently be used as γ-irradiation detector in many applications of ionizing radiation.https://ejchem.journals.ekb.eg/article_157065_a821f7b729116b56685c91e8ee2b86da.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives3691370116111710.21608/ejchem.2021.65453.3404ENAhmedEl-ShareefDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.AbdelhaleemHusseinDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.AbubakerEladasyDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.IsmailOthmanDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.AhmedKhamesDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.0000-0002-0536-1935Journal Article20210228New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzoylisothiocyanate and aminopyrazoles. The antimicrobial activities were also studied and have been found that; Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial specieshttps://ejchem.journals.ekb.eg/article_161117_b276471c5766ac67d0a52f01ad20d3a4.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701A Developed Method for the Estimation of Diclofenac Sodium via Coupling with Diazotized 4-Aminoacetophenone3703370916501010.21608/ejchem.2021.68509.3497ENSaharFadhelCollege of science/Diyala University/IraqAbbas Shebeeb HasanAl-kadumiCollege of science/Al-Karkh University for science/Iraq.Nuha A.ImranCollege of science/Diyala University/IraqMarwah H.AbdulateefCollege of science/Diyala University/IraqJournal Article20210319A recommended, simple and sensitive method for the spectrophotometric determination of diclofenac sodium drug (DLC) in pharmaceutical formulations was represented in this work. The method is based on the coupling of DLC with diazotized 4-Aminoacetophenone in basic medium to form an intense yellowish-brown colored diazocoupling product that showed maximum absorbance at 362 nm. The effect of various factors such as amount of the reagent, time of the reaction and order of addition were investigated. The experimental results indicated a good linearity (r2 = 0.9954) over a concentration range of (2- 40) µg/L with a detection limit of 0.447 µg.L-1 diclofenac sodium under the optimized conditions. The pharmaceutical excipients did not exhibit any interferences. The low value of the standard deviation alongside good correlation coefficient confirms the applicability of the method. Accordingly, the proposed method has been successfully applied to the determination of diclofenac sodium in pharmaceutical formulations. The results were statistically compared with standard methods by means of t-test and f-test at 95% confidence level with no significant differences observed.https://ejchem.journals.ekb.eg/article_165010_a2356d7f5666365f6e3d2a989556131b.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives3711371616608210.21608/ejchem.2021.68873.3508ENYasserMustafaPharmaceutical Chemistry Department, College of Pharmacy, Mosul University-41002, Nineveh, Iraq.0000-0002-0926-7428Raghad RiyadhKhalilDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraqhttp://orcid.org/000Eman TareqMohammedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraqhttp://orcid.org/000Journal Article20210321Compounds having their chemical structure based on coumarin framework have enticed much research concern not only because of the variance structural characteristic but also the pluralism of the bioactivities. In this report, four derivatives of 7-halo-4-coumarinylacetic acid referred to as RY1-RY4 were synthesized, and their chemical backbones were confirmed via the employed spectrophotometers. The pharmacokinetic profiles of the synthesized halocoumarins were inspected in silico using a free online software named the pre-ADMET program. The potential of the synthesized halocoumarins as antitumor applicants was evaluated utilizing 5-fluorouracil as a reference drug and the well-authenticated protocol based on the MTT as a visible indicator against eight standard tumor-cell lines. The outcomes acquired from this assessment indicated that the synthesized halocoumarins, except RY1, have less impact as antitumor agents comparing with the standard drug. Also, the halocoumarins revealed roughly the same fashion of activity versus the test cell lines with the greatest inhibitory influence reported against MCF-7 and HeLa. From the calculated pharmacokinetic data and outcomes exhibited from antitumor assessment, the authors concluded that the synthesized halocoumarins, particularly RY1, offered potential applicants as antitumor agents with broad-ranged activity. Besides, the compounds RY1 and RY2 may provide highly valuable scaffolds for synthesizing agents with a powerful antitumor activity versus the breast and cervical cancer phenotypes.https://ejchem.journals.ekb.eg/article_166082_fceb1388efed1c94ff44a196130ac632.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Enhancement for the fluorescent properties of new synthesized GFPs chromophore3717372716489110.21608/ejchem.2021.71465.3569ENBahaaElgendyChemistry department, faculty of science, Benha university, EgyptM.M.AzabChemistry department, faculty of science, Benha university, EgyptMarwaGamilChemistry department, faculty of science, Benha university, EgyptHesham H.El-FekyChemistry department, faculty of science, Benha university, Egypt0000-0002-8276-2222Journal Article20210407An alternative method for the synthesis of new GFP chromophore analogous that possess good photo physical properties which can be used as efficient biomarkers. These compounds have low fluorescence most probably due to their Z–E photo isomerization. These chromophores have suitable site for complexation with transitional metals. Forming complexes with metal ions can inhibit their photo isomerization and enhance the fluorescent properties.https://ejchem.journals.ekb.eg/article_164891_88efb4e7f4feebff228be5ec80ef12af.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Phytochemical Investigation and Differential Effects of Cestrum elegans Isolated Compounds as Antimicrobial and Virucidal against Hepatitis A Virus3729373817623910.21608/ejchem.2021.71934.3581ENSami MohamedNasrTheodor Bilharz Research Institute0000-0001-8683-3131Nehal MElwanchemistry department, faculty of science, cairo universityMonaAbdel-MotagalyTheodor Bilharz Research InstituteAbdel-Wanes AnterAbdel-AzizTheodor Bilharz Research InstituteMosadGhareebMedicinal Chemistry, Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, EgyptJournal Article20210411A new steroidal saponin, named as (25R)-6α-[(β-D-glucopyranosyl) oxy]-5α-spirostan-3β-yl β-D-glucopyranosyl (1''→3')-O-β-D-glucopyranosid (2) was isolated from the flowers of Cestrum elegans. In addition, a known steroidal saponin (1), a flavonoid compound (3) along with a triterpene saponin (4) were isolated for the first time in genus Cestrum and identified based on their chromatographic properties, chemical and spectral data (HR-ESI-MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC). The four compounds are characterized by different effects against Gram positive, Gram negative bacteria, antifungal and antiviral activities. The maximum non-toxic concentration (MNTC) on vero cell line was 1.56 µg/mL for all compounds. While compound 1 and 3 showed the highest biological activities against hepatitis A virus possess 34.3% and 25% antiviral activity respectively..https://ejchem.journals.ekb.eg/article_176239_e682c69964ff547dda0ad73e34f3ebaf.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Lyopene Nanoparticles Ameliorate The Antioxidants, Antimicrobial And Anticancer Potencies Of Tomato Pomace.3739374917359110.21608/ejchem.2021.71766.3583ENHabiba A.AhmedPlant Biochemistry Department, National Research Center, 12622 Dokki, Giza, Egypt.0000-0003-1150-9841Zeinab A.SalamaPlant Biochemistry Department, National Research Center, 12622 Dokki, Giza, Egypt.Salah H.SalemFood Toxicology and Contaminants Department, National Research Center, Cairo, Egypt.Hanan F.AlyTherapeutic Chemistry Department, National Research Center, 12622 Dokki, Giza, Egypt.AmrNassrallahBiochemistry Department, Cairo University Research Park, Cairo University, 12613 Giza, Egypt.0000-0002-2229-2855FatenAbou-ElellaBiochemistry Department, Cairo University Research Park, Cairo University, 12613 Giza, Egypt.Ahmed M.Aboul-EneinBiochemistry Department, Cairo University Research Park, Cairo University, 12613 Giza, Egypt.Journal Article20210411Nanoparticles are the basic essential element of nanotechnology and it exhibits characteristic features based on their properties such as size, morphology and other size dependent properties. Their applications on agriculture, food and medicine are widely used nowadays. Agro-waste materials cause a global environmental problem worldwide. Maximizing the benefits of such waste material is a very important issue. The present investigation aimed to use nano-formulation techniques by using polyethylene glycol 8000 to produce nano-lycopene extracted from tomato waste (pomace) as well as evaluation the antioxidant, antimicrobial and anticancer activity of produced lycopene-NPs. The results of antioxidant activity using ABTS and DPPH assays revealed that nano-formulation of Lycopene increases the scavenging activity compared with lycopene. Also, both lycopene and lycopene-NPs showed antibacterial activity against all tested bacteria and antifungal activity against tested fungal species. MIC for lycopene and lycopene-NPs was determined. DNA damage induced by oxidative stress protection analysis indicated that lycopene-NPs has a great potential in DNA damage prevention compared to their respective controls. The MTT assay exhibited cytotoxic activity against three cancerous cell lines, MCF-7, HCT-116 and HepG2. As well as lycopene-NPs biosafety was tested against normal cell lines (BJ-1 and MCF-12F) compared to lycopene.https://ejchem.journals.ekb.eg/article_173591_43e6d4754aaa3c03650f63613ac1e757.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Microwave-assisted Dyeing of Wool Fabrics with Natural Dyes as Eco- Friendly Dyeing Method: Part I. Dyeing Performance and Fastness Properties3751375916570110.21608/ejchem.2021.72134.3588ENMorsy A.El-ApaseryDyeing, Printing and Auxiliaries Department, Textile Industries Research Division, National Research Centre,
Cairo 12622, Egypt0000-0002-4686-2007Abdelhaleem M.HusseinDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptNahed M.Nour El-DinEcology and Range Management Department., Ecology and Dry Lands Agriculture Division, Desert Research
Center, 1 Mathal El-Mataria St, 11753 Matariya, Cairo, EgyptMohamed O.SalehDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptAbu-Bakr A.El-AdasyDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptJournal Article20210412In this study different Mixtures of folk plants (Artemisia monosperma and Phlomis floccose )in different proportions and different concentrations of the mixture are used to obtain new natural dyes and applying them to woolen fabric using microwave radiation and then studying the effect of extraction time and the pH of the dyeing bath on the strength of color and then studying the fastness of these dyes against light and Washing and perspirationhttps://ejchem.journals.ekb.eg/article_165701_92685a33dde6427d5eb11eed5e886188.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Microwave-assisted dyeing of wool fabrics with natural dyes as eco- friendly dyeing method: part II. The effect of using different mordants3761376616570210.21608/ejchem.2021.72139.3589ENMorsy A.El-ApaseryDyeing, Printing and Auxiliaries Department, Textile Research Division, National Research Centre, Cairo 12622, Egypt0000-0002-4686-2007Abdelhaleem M.HusseinDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptNahed M.Nour El-DinEcology and Range Management Department., Ecology and Dry Lands Agriculture Division, Desert Research Center, 1 Mathal El-Mataria St, 11753 Matariya, Cairo, Egypt.Mohamed O.SalehDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptAbu-Bakr A.El-AdasyDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, EgyptJournal Article20210412Our current study aims to study the effect of different metallic mordantson the new natural dyes that we were able to extract in a previous study. The extent to which the intensity of color is affected by the presence of metallic mordantshave been studied and also the effect of the concentration of each mordant on the natural dyes was investigated, and then the changes that took place on the color axes were screened, and then the fastness of the new dyes were studied after applying them to the woolen fabrichttps://ejchem.journals.ekb.eg/article_165702_820d9369b6f726811747d7b827ea049e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Optimized Synthesis of Biopolymer-Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity3767379017740510.21608/ejchem.2021.75677.3709ENTaha FarghalyHassaneinChemistry Department, Faculty of Science, Helwan University, Cairo, Egypt0000-0003-1829-9605Aya SamirMohammedChemistry Department, Faculty of Science, Helwan University, Cairo, Egypt0000-0003-2660-0824WaelMohamedDepartment of Polymers & Pigments, Chemical Industry Division, National Research Centre,
Dokki, Giza 12622, Egypt
Abstract0000-0001-5246-7620Rokaya AlySobhDepartment of Polymers & Pigments, Chemical Industry Division, National Research Centre,
Dokki, Giza 12622, Egypt
Abstract0000-0002-5004-2087Magdy KandilZahranChemistry Department, Faculty of Science, Helwan University, Cairo, Egypt0000-0001-7280-0734Journal Article20210508Owing to their unique properties, zinc oxide nanoparticles (ZnO NPs) have a broad range of exciting applications. However, the problem of nanoparticles aggregation remains challenging. So, biopolymers of polysaccharides can provide green and promising stabilizers as alternatives to the current toxic chemical stabilizers during ZnO NPs synthesis. The main idea in this investigation is to tune ZnO NPs with an appropriate texture, shape, and size for antibacterial application. So, this work compares the use of three different eco-friendly stabilizers namely starch, carboxymethyl cellulose, and hydroxyethyl cellulose as alternatives capping agents in the fabrication of ZnO NPs at various times. The optimized ZnO NPs sample was obtained using starch as the optimum stabilizer at reaction conditions of 0.5 h, room temperature (25 °C), 1:2) MZn:MNaOH) ratio and 1% (w/v) starch concentration. The optical, texture, and structural properties of prepared ZnO NPs were characterized by UV–Vis, DLS, zeta potential, FT-IR, and TEM techniques. ZnO NPs showed a mean zeta potential of −21.6 mV, explaining that they are moderately stable. The analysis by TEM confirmed that the NPs were spherical and have an average size of 23 nm. The antibacterial properties of ZnO NPs against Gram-positive (Bacillus subtilis and Staphylococcus epidermidis) and Gram-negative (Enterobacter cloacae and Escherichia coli) bacteria were evaluated based on the zone of inhibition (ZOI) values expressed in mm. The results showed promising performances for their antibacterial activity against the tested bacteria which indicated a strong antibacterial activity of ZnO NPs against B. subtilis, S. epidermidis, and E. cloacae with ZOI values of 17, 14 and 16 mm, respectively, and it showed moderate activity against E. coli (ZOI = 10 mm). The synthesis of biopolymer stabilized ZnO NPs by this approach could be eco-friendly and cost-effective and synthesized ZnO NPs can serve as promising antibacterial agents.https://ejchem.journals.ekb.eg/article_177405_ad9a0cbf9b3f9dc3ec16ae982d10e0e4.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Design, Synthesis and Antiviral Evaluation of New N-(4)-(benzo[d][1,3]-dioxol-5-yl)thiosemicarbazone Derivatives3791380017666810.21608/ejchem.2021.72649.3603ENSamir Y.AbbasOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, EgyptWael M.TohamyOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt0000-0003-0680-3085Wahid M.BasyouniOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, EgyptKhairy A.M.El-BayoukiOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, EgyptReham M.DawoodMicrobial Biotechnology Department, National Research Centre, Dokki, Cairo, EgyptMostafa K.El-awadyMicrobial Biotechnology Department, National Research Centre, Dokki, Cairo, EgyptFarid M.SroorOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt0000-0003-1283-2157Journal Article20210416A new series of N-(4)-substituted thiosemicarbazone derivatives 4-8 incorporating a benzo[d][1,3]dioxole moiety were synthesized through the reaction of N-(4)-(benzo[d][1,3]dioxol-5-yl)-thiosemicarbazide with various carbonyl compounds such as aromatic aldehyde, heterocyclic aldehyde, acetophenone, heterocyclic ketone and cyclic ketone derivatives. The structure of the prepared thiosemicarbazones was established based on spectroscopic IR, 1H-NMR, 13C-NMR and elemental analyses data. The antiviral activity of the synthesized compounds was tested against Bovine Viral Diarrhea Virus (BVDV).https://ejchem.journals.ekb.eg/article_176668_f22a4b2a020a2572fcf22984dafd648d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Seawater Reinforces Synthesis of Mesoporous and Microporous Zeolites from Egyptian Fly Ash for Removal Ions of Cadmium, Iron, Nickel, and Lead from Artificially Contaminated Water3801381617740710.21608/ejchem.2021.73834.3661ENLubna AbdelazizIbrahimAssociate prof. at Water Management Research Institute, National Water Research Center0000-0001-6128-1668ElSayed ElBastamyElSayedCentral Laboratory for Environmental Quality Monitoring (CLEQM), NWRC, Egypt.Journal Article20210426This study focuses on the production of mesoporous and microporous zeolites via fusion pre-treating fly ash with NaOH followed by hydrothermal treatment utilizing seawater. Three pretreatments for fly ash were carried out utilizing 1:1, 1.2:1, and 1.4:1 of NaOH:fly ash ratio to compare the removal efficiency for cadmium Cd(II), iron Fe(II), nickel Ni(II), and lead Pb(II) from artificially contaminated water. The impacts of several variables including concentrations, weights, pH, and contact times were examined to acquire knowledge on the adsorption rate. X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), and Brunaauer-Emmett-Teller (BET) were utilized to investigate zeolite structures. N2 adsorption/desorption isotherms demonstrated that the synthetic zeolites were mesoporous and microporous materials with a higher specific area (347, 240, and 127 m2/g) than the values for raw fly ash (15m2/g). The X-ray diffraction outcome suggested that the synthetic products mainly belonged to phillipsite, carbonate cancrinite, and hydroxysodalite. These outcomes showed that fly ash and seawater from power plants are appropriate for synthesizing high-quality zeolites. For contaminated water treatment, the products are effective for removal Cd(II), Fe(II), Ni(II), and Pb(II) at pH 7, contact time 45 min, and dose 1 g/L. Zeolites recycling outcomes showed that the removal efficiency of investigated metal ions by Z1, Z2, and Z3 was reduced by an average of 7%, 5%, and 3% after regeneration.https://ejchem.journals.ekb.eg/article_177407_a6f2908cbb4f941465fd1d31d7f94923.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Design, Synthesis and Molecular Docking of New Benzimidazole Derivatives of Potential Antimicrobial Activity as DNA Gyrase and Topoisomerase IV Inhibitors3817383917243110.21608/ejchem.2021.75953.3714ENWafaa A.ZagharyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, P.O. Box 11795, Cairo, EgyptManal M.AnwarDepartment of Therapeutic Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt0000-0002-3967-4534Somaia S.Abd El-KarimDepartment of Therapeutic Chemistry, National Research Centre, Dokki, Cairo 12622, EgyptGhada E.A.AwadChemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Cairo, 12622, EgyptGehad K.HusseinChemistry Department, Faculty of Pharmacy October 6 University El-Giza, EgyptNadia M.MahfouzChemistry Department, Faculty of Pharmacy October 6 University El-Giza, EgyptJournal Article20210510A new series of benzimidazole derivatives 3a-3d, 4a-4c, 8a-8d, 9a,9b, 10a-10d and 11 was synthesized and evaluated as antimicrobial agents against various gram-positive, gram-negative bacteria and fungi using vibramycin and fluconazole as positive controls for the antibacterial and antifungal activities, respectively. The examined microbial strains showed variable sensitivities against the target compounds.The examined microbial strains showed variable sensitivities against the target compounds. The minimum inhibitory concentration (MIC) was determined for the compounds showed zone of inhibition ≥ 16 mm (4a, 4c, 8a, 10a). The latter derivatives were also examined as S. aureus DNA gyrase/topoisomerase IV inhibitors. The compounds 4a, and 8a represented the most promising activity for both enzymes in ATPase assay (IC50 4a 0.39, 0.52 and 8a 0.66, 0.28 µM respectively) as well as the safest profile against the human normal WI38 cells upon comparing with Ciprofloxacin and Novobiocin. Compounds 8a showed dual inhibitory effect against both targets DNA gyrase and topoisomerase IV in supercoiling and decatenation assay (IC50 0.443 and 1.15 µM respectively). Both compounds 4a and 8a can be considered as lead compounds for further structural modifications to obtain more potent DNA gyrase and topoisomerase inhibitors as antibacterial agents. Molecular docking study was performed for the most promising compounds to explore the pharmacophoric moieties that governed their binding with amino acid residues of DNA gyrase and topoisomerase IV using MOE software. The results revealed a binding mode and docking scores comparable to those of a reference ligand and consistent with their DNA gyrase and topoisomerase IV inhibition activity.https://ejchem.journals.ekb.eg/article_172431_07d9df0e69a35eddaf4e0c59c868262e.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Cost-effective Clean Electrochemical Preparation of Ferric Chloride and its Applications3841385117572110.21608/ejchem.2021.75921.3717ENMona A.Abdel-FatahChemical Engineering & Pilot Plant Department, Engineering Research Division, National Research Center
33 El-Bohouth St., Dokki, Cairo, Egypt, Post Code 126220000-0003-1371-8938S. I.HawashChemical Engineering & Pilot Plant Department, Engineering Research Division, National Research Center
33 El-Bohouth St., Dokki, Cairo, Egypt, Post Code 12622H. H.ShaarawyChemical Engineering & Pilot Plant Department, Engineering Research Division, National Research Center
33 El-Bohouth St., Dokki, Cairo, Egypt, Post Code 12622Journal Article20210511In this investigation, a green, cost-effective clean electrochemical process for preparing a highly concentrated ferric chloride (FeCl3) solution has been proposed. Many operating conditions, affected the used anodic dissolution process for FeCl3 production, were studied. Generating ferrous hydroxide electrochemically then dissolving it by hydrochloric acid and oxidized with chlorine free mixed oxidant, were proceeded steps to reach the production of our target ferric chloride. It is a green, clean, and novel process because it is environmentally and industrial safer than the traditional production technology. The most important studied experimental variables were applied like applied current density, sodium chloride concentration, electrolyte pH, at the most controlling operating parameter which is optimum electrolysis time. Experimental results revealed that optimum current density was 300 mA/cm2; using 30gm/L saline solution, electrodes gap distance 5 cm, and stirring rate 150 rpm at pH 6.5 for 270 minutes, respectively. At these optimal operating parameters, 40% FeCl3 concentration can be prepared to consume 202 watts/liter of high quality with low capital, & operating costs. The economic indicators show that the running cost of production of 40% ferric chloride solution using the proposed cleaner electrochemical production technology will be 241.66$/ton and the suggested price is 450$/ton with a net profit of 156$ with high cash flow using the proposed green technology. The proposed methodology for FeCl3 production reviews the importance of using cleaner production and sustainable development indicators. <br /> https://ejchem.journals.ekb.eg/article_175721_109adec83e7483905e2068cd0fef418d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Determination of Trace Nitrite Amounts in Soil by Developed Cloud Point Extraction-Spectrophotometry Method3853385916569610.21608/ejchem.2021.61363.3325ENAliAbdulwahidDepartment of Chemistry, College of Science, University of Basrah, Basrah 61001, Iraq0000-0003-4245-7618YossraMarichDepartment of Chemistry, College of Science, University of Basrah, Basrah 61001, Iraq0000-0002-9058-7866HasanainAbdulkareemDepartment of Chemistry, College of Science, University of Basrah, Basrah 61001, IraqHadiAl-LamiDepartment of Chemistry, College of Science, University of Basrah, Basrah 61001, Iraq0000-0001-8716-6385Journal Article20210204A new and simple method for the selective and sensitive determination of trace amounts of nitrite in soil samples is developed by a combination of cloud point extraction (CPE) and spectrophotometry technique. The procedure is based on the Griess reaction on 3,3`-dimethyl benzidine with nitrite in the presence of 1-naphthol in acidic media to form a yellow diazo dye, which shows absorption at lambda max 455 nm. The formation of colored diazo dye is followed by extraction into the Triton X-114-rich phase. CPE method parameters such as surfactant amount, temperature, and incubation time are evaluated and optimized. The results showed a very good linear range of 10-1250 µgL-1, with good regression coefficients (R2) ≥ 0.9997 and a preconcentration factor of 12.5. The limit of detection (LOD) describes as 3SDblank/m, and the limit of quantification (LOQ) describes as 10SDblank/m, where ‘m’ is the slope of the calibration curve and they are equal to 7.50 and 22.71 µgL-1 respectively. The recommended method can apply to determine the ultra-trace amount of nitrite in soil samples.https://ejchem.journals.ekb.eg/article_165696_8a97685d9169b7e2fb98c0f36a336567.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis and Evaluation of New Cationic Polymeric Surfactant Based on N-phthalimidomethyl methacrylate3861387215882210.21608/ejchem.2021.54791.3224ENSh.M.AlazrakChemistry Department, Faculty of Science, Benha University, Benha, EgyptS.AwadBasic Science Department, Faculty of Engineering , Benha University, Benha, EgyptA.A.KhalilChemistry Department, Faculty of Science, Benha University, Benha, EgyptW.El-DougdougChemistry Department, Faculty of Science, Benha University, Benha, EgyptJournal Article20210106In our previous work N-phthalimidomethyl methacrylate (NPMMA) monomer was prepared through the reaction of N-hydroxymethyl phthalimide with methacrylic acid in the presence of N, N-dicyclohexylcarbodiimide (DCCI) as a condensing agent. Then a new series of copolymers containing imidazole have been synthesized through the reaction of NPMMA monomer with 1-vinylimidazole (VIM) in the presence of benzoyl peroxide as initiator. The copolymer composition was determined by 1H NMR spectroscopy and the values of monomer reactivity ratio (r1= 0.756, r2= 1.033, and r1r2= 0.781) were calculated through Fineman Ross and Kelen-Tüdös methods. Conversion of copolymers to surfactants was achieved through quaternization of the imidazole nitrogen with dimethyl sulphate. The chemical structure of the produced monomer, copolymers, co-polymeric surfactants was confirmed by spectroscopic tools. The surface properties included surface tension, foaming power, emulsion stability, critical micelle concentration (CMC) have been measured in aqueous medium by traditional procedures. Also the different air/ water interface parameters including effectiveness (πcmc), efficiency (Pc20), maximum surface excess (Γmax) and minimum surface area (Amin) were also recorded. Moreover, the biodegradability for these cationic surfactants has been investigated and their D % was ranged from 67 to 100 %.https://ejchem.journals.ekb.eg/article_158822_b39025104d2a7285a1b5a28280aa302d.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Modulation of cancer therapy using nano-organometallic compounds: preparation, spectroscopic characterization and cytotoxic evaluation.3873388715960210.21608/ejchem.2021.64313.3379ENAbdouEl TablDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt.MoshiraAbd-El WahedDepartment of Pathology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.EmanMohamedDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt.MohammedAbu-SettaDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt.Journal Article20210221New series of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) organometallic complexes with hydroxyl benzylidene malonohydrazide ligand have much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure activity relationships and elucidation of the specification of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS and ESR) spectroscopy, as well as magnetic moments, conductance, elemental and thermal analyses. Molar conductance in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (7) and (8) showed isotropic and anisotropic types indicating an octahedral geometry with covalent bond character. However, Co(II) complexes (3) and (4) showed anisotropic type where, g┴ > g|| >2.0023, indicating compressed tetragonal distortion around Co(II) ion. Cytotoxic evolution of the ligand and its complexes have been carried out. Complexes showed enhanced activity in comparison to the parent ligand or standard drug applied.https://ejchem.journals.ekb.eg/article_159602_605c4b8c1bcbeb7b43d5bd5e21fb9a2a.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, Characterization and Analytical Applications of Chemically Modified Cellulose for Remediation of Environmental Pollutants3889390115960710.21608/ejchem.2021.65793.3412ENMagda A.AklDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, EgyptAbdelrahman S.El-ZenyDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, EgyptMohamed A.HashemDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, EgyptEl-Sayed R. H.El- GharkawyDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt0000-0003-4193-0207Journal Article20210302Carbohydrazide functionalized cellulose (CH-MC) was prepared and characterized using some qualified techniques such as Scanning Electron Microscopy (SEM), Infra-Red (FT-IR), Elemental analysis (EA) and Thermogravimetric analysis(TGA) . The prepared CH-MC was employed for uptake of heavy metal ions such as, Hg2+and Cu2+ from different samples. Sorption parameters: such as pH, temperature, time of sorption and the concentration of sorbent were investigated to determine the best conditions for sorption. The kinetic of sorption agreed with the second-order model and the chemical adsorption is the rate-limiting step. In addition, the sorption isotherm experiments revealed that the best adequate with Langmuir model which the maximum adsorption capacities for Cu2+and Hg2+ metal ions on CH-MC are 43.3 and 64 mg/g, respectively. The real samples including Hg2+ and Cu2+were used for analytical applications on the present methodology and the observed data is promising.https://ejchem.journals.ekb.eg/article_159607_55c1cce6f464a9e5451dd673458784c3.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Effect of Antioxidants Intake on Oxidative Stress Among Mobile Phone Users3903391216323510.21608/ejchem.2021.69368.3521ENWeamShaheenAssisstant Professor of Environmental Health and Occupational Medicine. Environmental and Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, EgyptNagat M.AmerProfessor of Public Health. Environmental & Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, EgyptSalwa F.HafezProfessor of Occupational Medicine. Environmental & Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, Egypt.ShafikaNasserProfessor of Public Health. Public Health and Community Medicine Department Faculty of Medicine Cairo UniversityMahaGhobashiProfessor of Public Health. Public Health and Community Medicine Department Faculty of Medicine Cairo UniversityGeorgeMorcosAssistant Professor of Medical Biochemistry Department Faculty of Medicine,
Cairo University, Egypt. Basic Medical Science Department, Faculty of Medicine, King Salman International University.Mona AdelHelmyResearcher of Public Health. Environmental & Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, Egypt.Journal Article20210324The current study aimed to assess mobile phone usage intensity and evaluate potential oxidative stress exerted among mobile users then evaluate the effect of antioxidants supplement on oxidative stress status. Intervention study done on 150 students using mobile phones from both technical nursing institute and faculty of nursing, Cairo .University. Only (108) students completed to the post intervention phase. Questionnaire and assessment of electromagnetic field exposure from mobile phones was done. Malondialdyde, superoxide dismutase and catalase were measured pre and post supplementation. Mobile phones with two SIM cards, non-android mobiles and mobile phones owned by the medium users group had significant higher electromagnetic emissions. Malondialdyde was significant higher in high mobile users. Significant negative correlation between emissions from mobile phone and superoxide dismutase. After supplementation, significant improvement in superoxide dismutase and Catalase among both groups using mobiles (>5years and <5years), using one or two phones, using one or two SIM cards and in android mobile users. Moreover, Malondialdyde show significant reduction among non-android mobile users. It was concluded that exposure to low emissions from mobile phones could be fixed by dietary modification and increase antioxidant intake.https://ejchem.journals.ekb.eg/article_163235_b084ff498611b26652d5a480285a52bd.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Synthesis, Speciation, DNA Binding, Electrochemical and Antiproliferative Properties of Pd(II) Complexes Designed to Improve the Interaction with DNA3913392617995110.21608/ejchem.2021.74711.3679ENHaneen HAL-GedanyChemistry Department, Faculty of Science, University of Jeddah, Jeddah , Saudi ArabiaAzza AbdelwahabShoukryDepartment of chemistry, Faculty of Science, Cairo Universityhttps://orcid.org/00Saedah R.Al‐MhayawiChemistry Department, Faculty of Science, University of Jeddah, Jeddah , Kingdom of Saudi ArabiaJournal Article20210430With the success of cisplatin, extensive research resulted in the discovery of carboplatin (a second-generation drug), where the chloride is replaced by 1,1-cyclobutanedicarboxylate. In the current study, we continue our previous work on the binding behavior of [Pd(byp)(H2O)2]2+ with structural features enhancing the interaction with DNA. [Pd(byp)(gly)]+ (1) and [Pd(byp)(CBDCA)] (2), where byp is 2,2´-bipyridine, gly is glycine, and CBDCA is cyclobutane-1,1´-dicarboxylic acid, were synthesized and characterized. The stability constants and stoichiometries of the complexes formed between various DNA units and [Pd(byp)(H2O)2]2+ were investigated. The binding properties of (1) and (2) with CT-DNA were analyzed by UV-vis spectroscopy, viscosity measurements, and cyclic voltammmetry. The (Kb) value for complex (1) (Kb= 4.36x103 M−1 ) , suggests an electrostatic binding together with hydrogen bonding with the negative sites of CT- DNA. The higher (Kb) value of complex (2) (Kb= 2.11x104 M−1) indicates an intercalation binding mode, whereby a ring-opening reaction of CBDCA occurs, followed by the reaction with guanosine 5'-monophosphate to form [(Pdbyp)(CBDCA-O)(5'-GMP)]. The results from UV-Vis spectroscopy, thermal denaturation, viscosity, and cyclic voltammetry data, all reveal electrostatic binding of complex (1) and intercalation mode of complex (2). The antitumor effects of the two complexes were tested. The two complexes display dose-dependent anti-proliferation activity with a prediction of improved efficacy against cancerhttps://ejchem.journals.ekb.eg/article_179951_14a857c44d76d28f52cba198be823d40.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Improving structure and properties of lead phosphate glass through precipitation of few crystals from CeO23927393316758610.21608/ejchem.2021.53105.3124ENFauzia ZaidGjamphysics department , faculty of science, Mansoura universityGomaaEldamrawiPhysics Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.Mahrous ShakerMeikhailPhysics Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.MohamedAbdelghanyGlass Research Group, Physics Department, Faculty of Science, Mansoura University, Mansoura 35516, EgyptJournal Article20201219New lead-cerium phosphate glasses in the system xCeO2(50-x)PbO-50P2O5 were successfully prepared by the melt-quenching process. The amorphous and/or crystalline character of the as prepared compositions were confirmed by both X-ray powder diffraction (XRD) and electron diffraction patterns (EDP) related to transmission electron microscopy (TEM). The surface morphology and the analytical amounts of glasses constituents have been studied by scanning electron microscopy (SEM) equipped with Energy-dispersive X-ray spectroscopy (EDX) apparatus. It was found that P2O5 as a host network can dissolve extremely high concentration from CeO2 without crystallization of the host glass network. Some cerium phosphate (CeP2O6) clusters can be formed and precipitated in the main amorphous network, particularly in glasses of high CeO2 contents ˃ 20 mol%. Formation of such type of clusters has an effective influence on enhancing material structure and properties, since the hardness number of the studied materials is highly enhanced. The chemical shift 31P NMR of glasses is improved toward increasing shielding process by the effect of CeO2 addition.https://ejchem.journals.ekb.eg/article_167586_1c25af443f6d9c3e794970c2a4f32f30.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Evaluation of Sand Filter as a Non-conventional Post Treatment of Oil Refinery Wastewater: Effect of Flow Rate3935394215882310.21608/ejchem.2021.61387.3318ENHossam F.NassarEnvironmental Science and Industrial Development Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt.0000-0002-5410-154XMariamFawzyWater Pollution Research Department, National Research Centre, Giza, 12622, Egypt0000-0002-0552-5581Journal Article20210203This work aims to evaluate the treatment efficiency and feasibility of a sand filter as a post treatment for a primary treated effluent from activated sludge process (ASP) of oil refinery wastewater (ORWW) at different flow rates. There are several factors influencing the treatment efficiency of the used sand filter including; wastewater characteristics, sand media and flow rates. The treatment unit consists of opaque sand filter column fabricated from PVC material. It was fed by a primary treated effluent from ASP of ORWW. The average concentrations of raw ORWW for turbidity, Chemical oxygen demand (COD), Biological oxygen demand (BOD), Total suspended solids (TSS) and phenol were 419 NTU, 409 mgO2/L, 118 mgO2/L, 111 mg/L and 2 mg/L, respectively. The sand filter was operated at three different flow rates namely; 120 L/h, 240 L/h and 360 L/h. The experimental results proved that 240 L/h is the optimum flow rate. The achieved removal values at this flow rate were 79.04%, 55.82% and 63.55 for turbidity, COD and TSS, respectively. The treated permeate complies with the National Regulatory Standards for irrigation and/or safe discharge on water streams after slight disinfection.https://ejchem.journals.ekb.eg/article_158823_dfd244294f864140a2f6311c55e3ab2c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Structural and some physical properties of Sodium Boro-phosphate Glass Containing Mill Scale.3943395017571810.21608/ejchem.2021.68425.3494ENA. S.El-SayedEgyptian Metrological Authority, Cairo, EgyptA. G.MostafaPhys. Dept., Faculty of Science, Al-Azhar University, Nasr City, Cairo, EgyptW.E.MadcourN.R.C., Egyptian Atomic Energy Authority, Cairo, EgyptM. Y.HassaanPhys. Dept., Faculty of Science, Al-Azhar University, Nasr City, Cairo, EgyptJournal Article20210318Sodium boro-phosphate glasses containing different amounts of mill scale (65% FeO and 35% Fe2O3) [an iron industry waste formed during the rolling process to produce steel plates] were prepared by the melt quenching technique. The structure and some physical properties of the prepared glasses were investigated using different tools. The amorphous phase of the prepared glass samples was confirmed from their X-ray diffraction. The experimental and empirical densities were found to increase, while the experimental and empirical molar volumes were found to decrease, as mill scale content was increased. By comparing both the experimental and empirical values of density and molar volume, the amorphous nature and short range order character of the studied glasses was confirmed. It was found also that all glass samples behave like semiconductor and both electronic and ionic conductivities were present in these glasses. The correlated barrier hopping model is the appropriate conduction mechanism. The conductivity was found to increase as mill scale content was increased from 10 to 25 mol% , then decreased at sample contains 30 mol% of mill scale, The IR analysis indicated that the iron cations occupy the glass network modifier positions, while the iron cations occupies the glass network former positions only in the sample containing 30 mol% of mill scale. It indicated also that phosphorous cations occupy mainly the tetrahedral coordination state. The volume, mass and molar magnetic susceptibility measurements exhibited gradual increase as mill scale content was increased in the sample composition and all the samples exhibit paramagnetic character.https://ejchem.journals.ekb.eg/article_175718_5e01ee78625257f085f477bc4468347c.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701A new philosophy in fabrication pesticides (Abamectin) and Essential oils (Orange oil) into nano-form3951395915998610.21608/ejchem.2021.62582.3426ENBassem A.SoudyApplied Center of Entomonematodes, Faculty of Agriculture, Cairo University, Giza, Egypt.Sally F. M.AllamZoology and Agricultural Nematology Department, Faculty of Agriculture, Cairo University, Giza, Egypt.M. F .HassanZoology and Agricultural Nematology Department, Faculty of Agriculture, Cairo University, Giza, Egypt.Nasr .S .Khalilpesticides analysis Research Department Central Agricultural Pesticide Laboratory, Research Institute, Agricultural Research Centre, Dokii, Giza, Egypt.Dalia AbdellahYoussefDepartment of Pests and Plant Protection, National Research Centre, Dokki, Cairo, Egypt.Journal Article20210306A new philosophy and new formulation of pesticide nanoemulsion abamectin and limonene have been tested for its adult activity against Tetranychus urticae Koch. The presence of abamectin and limonene in the formulation was confirmed by Transmission Electron Microscope and Gas Chromatography-Mass Spectrometer. The dose-response data of T. Urticae indicated that the abamectin and limonene TC was more toxic to the pest than its commercial one. Arranged the toxicity values of some treatment based on LT50 values tested against T. urticae in descending orders as follows abamectin1.8%, nano abamectin TC, nano abamectin 1.8%, and abamectin TC. Nano abamectin TC is the second level but is the lowest dose with high absorption and fast toxicity. It was shown that nano orange oil TC was the most effective essential oil and thymus oil was the least effective oil. LC 50 values were 11.21%, 12.17%, 16.11% and 19.17 % for nano orange oil TC. orange oil 6%, nano orange oil 6%, and orange oil TC respectively after 96hr post-treatment. Time of Absorption on Plant Leaves per minutes was the lowest time in leaves absorption nano orange oil (10.33,15.16,21.14,21.25,23.12,33.09,39.13 and 48.08 respectively) for (nano orange oil TC, nanoabamectin TC, orange oil TC nano orange oi l6% nanoabamectin 1.8% abamectin 1.8% orange oil 6% abamectin TC respectively).nano orange oil was more absorption than orange oil TC by 21%. Our findings indicated that nano shape in TC form and then make pesticide formulation was more effective and more absorption in plant leaves against T. Urticae than abamectin and limonene in normal shape and formulation nano shape conversion. The required concentration for controlling T. Urticae decreased more then. because active ingredients became more speared in formulation This approach might be successful examples for decreasing the resistance of this pest to pesticides and reduce environmental pollution.https://ejchem.journals.ekb.eg/article_159986_3a8150a05f0b8d1a213d359924936016.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Role of CNK1, Ephrin B1, GPR19 and SMURF1 in breast cancer early diagnosis, metastasis and drug resistance3961396917570910.21608/ejchem.2021.77940.3833ENAfnanAbdrabouBiochemistry department, faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt.0000-0001-6985-2955Sara MRadwanBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt0000-0002-7994-093XReham AEl ShimyClinical and chemical Pathology, National Cancer Institute NCI, Cairo University, Cairo, Egypt.0000-0002-1470-985XHalaEl MesallamyBiochemistry, Faculty of Pharmacy, Sinai University, Sinai, Egypt0000-0001-8190-536XJournal Article20210530Abstract:<br /> Background: The extracellular signal-regulated kinase (ERK) pathway is a key signaling pathway involved in the regulation of normal cell proliferation, survival and differentiation. However, aberrant regulations of the ERK pathway contribute to cancer and other human diseases.<br /> Objective: This study was designed to investigate the role of some ERK pathway effectors such as the connector enhancer of kinase suppressor of Ras1 (CNK1), Ephrin B1, G protein-coupled receptor 19 (GPR19) and SMAD ubiquitination regulatory factor 1 (SMURF1) in breast cancer (BC) diagnosis and metastasis risk prediction.<br /> Methods: The study involved 50 (ER-PR-Her2+=6, ER+PR+Her2+=11, ER-PR-HER2-=8, ER+PR+Her2-=25) newly diagnosed BC patients, 15 chemotherapy resistant BC patients, 15 benign breast tumor patients and 10 controls. All total 65 BC patients (including the chemotherapy resistant group) were subdivided into two groups: metastatic BC (17 patients), and non-metastatic BC group (48 patients). CNK1, Ephrin B1, GPR19 and SMURF1 serum levels were analyzed using ELISA.<br /> Results: The study revealed significantly higher serum levels of CNK1, Ephrin B1, GPR19 and SMURF1 in all malignant groups (ER-PR-Her2+, ER+PR+Her2+, ER-PR-HER2-, ER+PR+Her2-), as well as a significant elevation in the chemotherapy resistant BC group as compared to non-resistant group (P < 0.001). They also revealed excellent value for de novo BC diagnosis and metastasis prediction.<br /> Conclusion: CNK1, Ephrin B1, GPR19 and SMURF1 may be considered as novel biomarkers for BC diagnosis and prediction of metastasis risk.https://ejchem.journals.ekb.eg/article_175709_c428b13ea28616693855ac198a4d9a28.pdfNational Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRTEgyptian Journal of Chemistry0449-228564720210701Activity of inorganic salts on different properties of synthetic leather3971397918246910.21608/ejchem.2021.77438.3781ENOla A.MohamedTanning Materials and Leather Technology Department, Chemical Industries Division, National Research
Centre, Cairo, Egypt.Amira S.Abd-El-AllNatural and Microbial Products Chemistry Department, Pharmaceutical Industries Research Division, National
Research Centre, Cairo, Egypt.Ragab A.MasoudTanning Materials and Leather Technology Department, Chemical Industries Division, National Research
Centre, Cairo, Egypt.HamedElsayedTanning Materials and Leather Technology Department, Chemical Industries Division, National Research
Centre, Cairo, Egypt.0000-0002-6463-258XJournal Article20210524As a matter of fact, it has been witnessed that the synthetic leather is becoming the main substitute to its natural leather counterpart. This phenomenon has been observed in the vast majority of fields where these materials are being exploited such as: vehicles interior materials and furniture skin materials. All of which urges the presence of fundamental characteristics that include but not limited to the soft texture, flexibility, mechanical strength and durability. Since these have the responsibility of being easy to burn, flame retardancy is required. In this article inorganic salts with different concentrations are used as flame retardants to synthetic leather as they cheaper and safer than halogenated one; Pot. Persulfate K2S2O8 (FRA), Sod. Nitrite NaNO2 (FRB), Di Sod. Tetaborate (Borax) Na2B4O7(FRC), Sod. Sulphite anhydrous Na2SO3 (FRD) and Sod. thiosulphite -5-hydroxy Na2S2O3 5H2O (FRE). The current article addresses the focal role of inorganic salts with variable concentrations plays in the process of enhancing the synthetic leather flame retardants. The treated leather was evaluated with different tests, physical properties as thickness, hardness, water vapor permeability and water absorption were determined. In addition, mechanical properties, tensile strength and elongation at break % of the treated leather were evaluated. Thermal stability was determined through, thermal gravimetric analysis (TGA) and the enhancement in the flame retardancy of leather was investigated using horizontal burning test. Correspondingly, delaying firing process help in caring the synthetic leather from burning; led to save money. So the treated synthetic leather be able to use for different manufacturing applications.https://ejchem.journals.ekb.eg/article_182469_8031d0b076a14392bc6edca9573d7d2f.pdf