2024-03-29T10:00:35Z
https://ejchem.journals.ekb.eg/?_action=export&rf=summon&issue=6668
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Synthesis, Reactions, and Antimicrobial Activity of N-Hydroxy-triacetonamine Derivatives
Mahmoud
Yousif
Ahmed
Fayed
Nabil
Yousif
Simple and one step method for preparation of N-hydroxy-2,2,6,6-tetramethyl-4-piperidone is reported. N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with formaldehyde, formaldehyde and piperidine to afford compounds (3) and (4) respectively. Compound (1) reacts with sodium azide and α-bromosugar to afford corresponding products. Compound (1) reacts with 2-(4-chlorobenzylidene)malononitrile to afford 1,6-napthyridine derivative (9). N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with p-chlorobenzaldehyde and cyanoacetamide to produce 1,6-napthyridine derivative (10a). N-Hydroxy derivative (1) reacts also with p-chlorobenzaldehyde and ethylcyanoacetate to afford 1,6-napthyridine (10b). Antimicrobial screening of some of the synthesized compounds has been performed.
2
6
6-Tetramethyl-4-piperidone
triacetonamine
N-hydroxy-triacetonamine
Formaldehyde
2019
08
01
1359
1366
https://ejchem.journals.ekb.eg/article_28325_aaa973f9fee4fadfd6770e6d8a62dd39.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Effect of Friction Stir Welding Process Parameters and Post-Weld Heat Treatment on the Corrosion Behaviour of AA6061-O Aluminum Alloys
Mostafa
Eldeeb
Lobna
Khorshed
Sayed
Abdallah
Ahmed
Gaafer
Tamer
Mahmoud
The aim of the present work is to study the effect of rotation and welding speeds as well as the T4 and T6 post-weld heat treatments (PWHT) on the corrosion behavior of AA6061-O aluminum plates joined using friction stir welding (FSW). The corrosion properties of welded joints were studied by Potentiodynamic polarization and Immersion tests. The results showed that both T4 and T6 PWHT improves the corrosion resistance of stirred zones compared to base alloy. However, joints of T4 showed lower corrosion resistance compared to T6. Increasing welding speed or reducing rotation speed increased the corrosion resistance of joints.
Friction Stir Welding
AA6061 aluminum alloy
Immersion test
Potentiodynamic polarization test
2019
08
01
1367
1375
https://ejchem.journals.ekb.eg/article_28683_e29a50b74bbe182051dd372f8cd67c47.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Microwave Assisted Peptide Synthesis of Some Rationally Designed Cell Penetrating Peptides from C-Kit Receptor
Shaimaa
Osman
Sarah
Jones
Mohamed
Zewail
Abdelgawad
Rabie
Ahmed
Shalaby
John
Howl
In the interest of public health, cell-penetrating peptides (CPPs) have proven to be important way for the highly efficient intracellular delivery of bioactive cargos like peptides, proteins, and oligonucliotides. It is feasible to combine one or multiple CPPs with bioactive cargos either by direct chemical conjugation or, more rarely, as non-covalent complexes. The term bioportides was introduced to describe monomeric CPPs that are intrinsically bioactive. One of the consistent problems that may compromise the in vivo applications of CPPs and bioportides, is the stimulation of mast cell (MC) secretion. Therefore, in this study two decapeptides, S6 and S6P, has been designed from the c-kit protein, a mast cells receptor, and synthesized using the technology of microwave assisted solid phase peptide synthesis. In an attempt to find bioportides from the c-Kit protein, and studying their structure- activity relationship, the present work was carried out, investigating the effect of the presence of the phosphotyrosine moiety as an active site in the synthesized peptides.
Microwave assisted solid phase peptide synthesis
Cell-penetrating peptide
Bioportides
C-Kit receptor
2019
08
01
1377
1389
https://ejchem.journals.ekb.eg/article_28326_f669e745d1325ddc44a89c6a3679444d.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Physical Distinguishable of Heterogeneous Overlapping Resulting from Stamp-pad and Laser Printing Inks
Samia
Shraa
Abdel Aleem
Abo Elmagd
Yasser
Moustafa
Al-Sayed
Bakr
Ahmad
Shabana
Ibrahim
Abd El-Aziz
Detecting the arrangement of intersecting stamp-pad ink and toner laser printing strokes is an excellent method of examining the documents originality. In this study, different six brands of stamp-pad inks, five laser printers of various brand and model, three types of paper surface, two kinds of seal materials and three methods of seal manufactures were utilized to produce the samples of heterogeneous intersecting strokes. A combination of the microscopic method as a digital microscope and analytical instrumental technique as Raman spectroscopy were performed to determine the arrangement of intersecting strokes. The digital microscope succeeds in detection the arrangement of intersecting strokes of some stamp-pad ink and fails in detection the others depending on their brands and colors through notation four physical properties at intersection point the specular reflection, the ink and toner gloss, gaps and spreading. The Raman spectroscopy determined the ink or toner stamped or printed later by comparison the spectra of pure ink, toner and their intersections and succeeds in detection all samples through the spectral data such as peak location and peak intensity. The combination of a digital microscope and Raman spectroscopy which applied here successfully discriminates the arrangement of intersecting strokes of toner and all brands of stamp-pad inks regardless of their brands and color.
Forensic discrimination
Strokes intersection
Stamp-pad inks
Toner laser printer, Seal inks
2019
08
01
1391
1412
https://ejchem.journals.ekb.eg/article_28843_5b7907d8c0ee549485759766ac8a8267.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Shear Properties of Apparel Fabrics Using Different Spun Yarns
Ahmed
Ramadan
Mohamed
Abo Hayes
The shear properties of a fabric determine its performance properties as well as the appearances where it is subjected to a wide variety of complex deformations during usage as apparel. In This paper, woven fabrics have been made of cotton spun yarns with three different spinning techniques (ring spun, open-end spun and compact ring spun yarns) in weft direction. Some twill based weave structures were manufactured on the weaving machine with varying the weft density level. The Kawabata Evaluation System were used to measure the shear properties; shear rigidity, shear hysteresis at 0.5 deg. shear angle and shear hysteresis at 5 deg. shear angle. A statistical analysis was performed to get the effect of decided parameters on shear. A highly significant effect of the weave structures and weft density on the measured shear properties were found, while the type of weft yarns has insignificant effect. A multiple linear regression equations were derived to get a mathematical relationship between the influencing parameters; (the float length, yarn diameter, and weft density) and the shear properties. The derived regression equations had high correlation coefficients values.
woven fabric
shear angle
spinning techniques
weave structure
apparel fabrics
Kawabata Evaluation System
Regression Analysis
2019
08
01
1413
1418
https://ejchem.journals.ekb.eg/article_27794_e5c2dc141c9e79eb51c634f8809dad1d.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Facile Synthesis of Textile-Based Filter for Industrial Wastewater Treatment
Heba
Gamal
Nour
Attia
In this study, cotton and polyester textile fabrics have been treated with polyaniline layer to use as smart filter for industrial wastewater treatment. The developed filters were effective to anchor the dissolved dye wastewater molecules. The polymerization of polyaniline chains on textile fabrics was assured by microscopic techniques. Also, the electrical resistance of treated samples was significantly reduced recording 20 and 40 kΩ for cotton and polyester-PANI filter respectively. The textile-based filter was tuned to be selective to negative dye molecules dissolved in water. The mass ratio of dissolved dyes was varied with developed filter and achieved 45% removal efficiency. The developed textile-based filter was characterized using various spectroscopic and microscopic techniques. The concentration of waste dyes molecules before and after treatments was determined and efficiency of filter was evaluated.
Wastewater
Textile fabrics
Polyaniline
Filter
Textile filters
2019
08
01
1419
1426
https://ejchem.journals.ekb.eg/article_27447_b9968d140451d2794cf1129bd4812a81.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Synthesis, Antimicrobial Activity and Quantum Calculations of Novel Sulphonamide Derivatives
Asmaa
Fahim
Eman
Ismael
The reactivity of 2-bromo-N-(phenylsulfonyl)acetamide derivatives 3a-c towards some nitrogen-based nucleophiles was studied in this investigation and gave the corresponding aminothiazole 6a-c, amino-oxazole 7a-c, quinazoline-2-yl 10a-c; respectively. Furthermore, the reaction of acetamide derivatives 3a-c with aminopyridine gave pyridine-4-ylamino 12a-c. Reaction of acetamide derivatives 3a-c with benzo-2-thiol derivatives afforded benzo [d] thiazol-2-ylthio 14a-c and 1H-benzo[d]imidazol-2-yl)thio derivatives 16a-c; respectively. The synthesized compounds displayed good antimicrobial activity. Additionally, compounds 12a and 14a exhibited high activity towards most of the strains. The computational calculations for 12a and 14a were carried out via HF/6-31G(d) and DFT B3LYP/6-31G(d) basis sets and the corresponding results of HOMO–LUMO energy gap and Mulliken atomic charges were tabulated. This correlation between experimental and theoretical calculations provided a good confirmation for anticipated new compounds.
Sulfonamide derivatives
antimicrobial activity
Computational study
2019
08
01
1427
1440
https://ejchem.journals.ekb.eg/article_27448_1a92e9ee0c0abc3a3dd8e9ddde48d200.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Hydrazone Analogues: Molecular Modeling, Synthesis, In- vivo Anti-Nociceptive Activity and in-vitro Antimicrobial Activity
Jebastin Sonia Jas
M
Marimuthu
G
B.
Prithivirajan
The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic resistant pathogens, functioning an ever- increasing used for new drugs. In an effort to develop antimicrobial agents a series of hydrazones derivative (4a-e) were synthesized from chalcones. Substituted hydrazides were reacted with chalcone in the presence of acetic acid and hydrazone derivatives were synthesized. The synthesized hydrazones were characterized on the basis physical and spectroscopic data and were evaluated for their antimicrobial activity against various bacterial and fungal strains using disc diffusion method using nutrient agar media. In addition, the antinociceptive activities of the products were evaluated. Our data showed that many derivatives have promising activities as antinocicepative agents.Furthermore the assessment of structural similarity of the target compounds with various standard drugs was done. Evaluation of the compounds revealed remarkable antibacterial, antifungal and antioxidant activity. In addition, an in silico docking study was performed in order to explain the possible interactions and the docking scores of all the compounds into the crystal structure of DNA Gyrase (Pdb code : 3U2D) using Online docking server program.
Chalcone
hydrazone
docking
DNA Gyrase
Anrtomicrobial activity
antinocicepative
2019
08
01
1441
1450
https://ejchem.journals.ekb.eg/article_27687_ac739ad18921501a46c1d57d7e9e37c0.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Ultrasound One Pot Synthesis of Fused Quinazolinones and Quinazolinediones, Screening and Molecular Docking Study as Phosphodiesterase 7A Inhibitors
sherin
Elfeky
Tariq
Sobahi
Magdy
Gineinah
Nesreen
Ahmed
Phosphodiesterase 7A enzyme is one the most recent targets for designing potent anti-inflammatory agents with minimal side effects. Quinazolinones are unique building blocks of wide biological activities. Different Quinazolinones were reported to act as Phosphodiesterase 7A inhibitors anti-inflammatory particularly against choronic inflammation and autoimmune disease. Ultrasound is a green convenient method for synthesis of different heterocyclic ring system that is advantageous in terms of yield and reaction time. Ultrasound was used for one pot synthesis of 3-substituted 6-aryl-dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 3-Aryl quinazoline-2,4(1H,3H)-diones. Seventeen compounds were synthesized in good yields. The synthesized compounds were inspected for in vitro inhibitory activity against phosphodiesterase7A enzyme. Molecular docking was used to study the mode of interaction of all the synthesized compounds into the enzyme phosphodiesterase 7A binding site. Five compounds showed high inhibitory activity of enzyme Phosphodiesterase 7A at micro-molar level compared to reference drug. The compounds showed good recognition at the enzyme binding site in the molecular docking. There was a good agreement between the molecular docking and the biological screening results.
Docking study
Phosphodiesterase 7A inhibitory assay
In vitro screening
Quinazolinedione
Dihydroisoindoloquinazolinone
2019
08
01
1451
1466
https://ejchem.journals.ekb.eg/article_27688_93a6b246ef61d40ce3d6751fd216985c.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Effect of Magnetic Treatment of Potable Water in Looped and Dead End Water Networks
Emad
El-Kashef
Ashraf
El-Shamy
Ahmed
Abdo
Elshafie A. M.
Gad
Amr A.
Gado
Potable water was exposed to permanent magnetic field (PMF) with a magnetic flux density (B=1.45 T ± 0.05) to investigate its effect on some water parameters for different time intervals at open and closed flow conditions at flow rate of 41.93 L/min and 52.16 L/min , respectively. Such as these parameters are; electrical conductivity (EC), total dissolved solids (TDS), pH and temperature. In the existence of this permanent magnetic field, so these pervious parameters were also studied as a function of water flow rate in case of the open loop system. The results showed that the PMF fluctuates the tested parameters of the outflow of this potable water at the previous flow conditions. These effects are owing to the hydrogen bond network. Theoretical approach of calculating inter-molecular interaction energy of H-bonded systems of water clusters under the effect of magnetic field is performed using DFT (Density Functional Theory) level with B3LYP function on Gaussian 09 Program.
TDS
EC
Flow rate
Permanent magnetic field
potable water
2019
08
01
1467
1481
https://ejchem.journals.ekb.eg/article_27689_1a2796c383e24195dcabad353f4cbc39.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Biophysical Properties of Polymethyl Methacrylate Blended with Maleated Castor Oil Filled with Calcium Carbonates in the Micro and Nano Scales
Mona
Saied
Azza
Ward
Azima
Saad
Kamal
Nasr
Hamdeya
Zayed
The biophysical properties of films prepared from polymethyl methacrylate (PMMA) blended with maleated castor oil (COMA) with composition 70/30 wt% filled with different concentrations of calcium carbonate (CaCO3) in the micro and nano scales have been studied. The incorporation of the filler in the polymeric matrix exhibits remarkable improvement in its properties. The prepared films were characterized through different techniques such as, thermo gravimetric analysis TGA, scanning electron microscope SEM, differential scanning calorimetry DSC, in addition to dielectric properties which were carried out at range of frequency from 0.1 Hz to 5 MHz and temperature range from 30 to 90 oC. The data obtained for the two investigated systems indicate that the dielectric permittivity ε' and dielectric loss ε" increased by increasing either the concentration of the filler or the temperature. The analysis of the imaginary part of the electric modulus M" which was carried out using Havriliak-Negami function revealed three relaxation times characterizing the conductivity relaxation, segmental molecular motion and the local motion of the side groups attached to the main polymer chain. The slight decrease in such relaxations noticed above 60oC (Tg) could be attributed to the cooperative reorientation motion of the polymeric segments, while that happened at concentration above 30 wt % from the micro and above 10 wt % from the nano filler could be attributed to the retardation of the dipole matrix which become weak.This result is supported by the calculations of the activation energies carried out using Arrhenius equation.The electrical conductivity σ were studied over frequency range (0.1Hz to 5 MHz) indicated that COMA is recommended to be used for electrostatic dissipation applications. Moreover the enzymatic degradation was carried out by immersing the prepared films in phosphate buffer solution. The weight remaining was found to decrease with the increase in either the time of immersing or the concentration of the filler added.
Biophysical,Castor oil
Dielectric permittivity
Electrical conductivity σ
Enzymatic degradation
2019
08
01
1483
1498
https://ejchem.journals.ekb.eg/article_28187_a3fb3afde0b89110f6313d21a0ef7295.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Removal Comparative Study for Cd(II) Ions from Polluted Solutions by Adsorption and Coagulation Techniques Using Moringa Oleifera Seeds
A. A.
Swelam
sheref
saied
Ahmed
hafez
The Moringa oleifera seed (MOS) was characterized by pHzpc, Fourier transform infrared spectroscopy (FT-IR), X-ray and scanning electron microscopy (SEM) in order to get an insight of the surface charge, functional groups, and morphology of the biosorbent, respectively. The MOS studies were conducted on Cd (II) with different parameters, such as solution pH, contact time, initial concentration of the pollutant and temperature were examined. Experimental results revealed an increase of the removal percentage of Cd (II) using adsorption compared with coagulation technique with increases of the initial Cd (II) concentration and contact time. However, an opposite trend was observed with an increase of the solution temperature and solution pHs value. The Freundlich isotherm linear equation are better described for the adsorption process and coagulation process for the removal of Cd (II) ions. By Comparing the thermodynamic parameters of Cd (II) removal, such as ∆H, ∆S and ∆G, distinct behaviours were observed, where adsorption process is positive values along all temperatures while coagulation process showed negative values (with exception of -∆G at 277 K). According to S* value, the adsorbent system are very high while the coagulation system are very low Keywords; Moringa Oleifera seeds, Cd (II), Adsorption, Thermodynamics.
Keywords
Moringa Oleifera seeds, Cd (II), Adsorption, Thermodynamics
2019
08
01
1499
1517
https://ejchem.journals.ekb.eg/article_28473_1009e610d8f129c19d96c5304ef32287.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Spectroscopic Investigation of Para-Methyl and Para-Methoxy Maleanilinic Acids in Comparison with Thermal Analyses and Theoretical Calculations and Evaluation of Cytotoxicity Against Carcinoma Cells
mohamed
Zayed
Mohamed
El-Desawy
AZZA
Eladly
Two novel N-maleanilinic acid derivatives (I-II) namely (E) – oxo -4- ((4- methyl phenyl) amino)-4- oxobut-2-enoic acid (p-MMA) and (E) -4- ((4- methoxy phenyl) amino)-4- oxobut -2- enoic acid (p-MOMA) were prepared by solvent free reaction between maleic anhydride and a p- methyl and p-methoxy aniline derivatives in a good yield. These compounds were synthesized and investigated using elemental analyses, FT-IR and thermal analyses under argon atmosphere. The crystallographic structures of studied compounds were investigated by X-ray diffraction (XRD). The molecular structures of the titled compounds in the ground state were optimized by DFT/B3LYP and HF methods with 6-311G++ (d,p) basis set. Calculations were carried out by GAUSSIAN 09 suite of programs. Natural bond orbitals (NBO) analysis and frontier molecular orbitals were performed using NBO 3.1 program implemented in the Gaussian 09 package are presented at the same level of theory. Thesis results were tabulated. This research aims chiefly to correlate between the structures of these investigated derivatives using experimental techniques in comparison with the theoretical molecular orbital (MO) calculated parameters. This correlation between experimental and theoretical calculations provided a good confirmation of the proposed structures of the newly prepared compounds. The derivatives were found to be highly effective against Hepatocellular carcinoma cells > Breast carcinoma cells > colon carcinoma cells. It was recognized, that cancer cells over expression promotes tumorigenic functions; were suppressed by p-MMA > p-MOMA inhibitors.
N-maleanilinic acids
spectroscopy (FT-IR)
thermal analyses
XRD
DFT calculations
biological activity against Carcinoma cells
2019
08
01
1519
1536
https://ejchem.journals.ekb.eg/article_28474_739891cb60198e5e3f4c88d0ddc8ac89.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Removal of Phosphate Ions from Wastewater by Treated Hydrogel Based on Chitosan
Ghada
Mahmoud
Mohamed
Abdel Khalek
Eman
Shoukry
Mona
Amin
Aya
Abdulghany
Chitosan/ Gelatin/2-(Dimethylamino) ethyl methacrylate (Cs/Gltn/PDMAEMA) hydrogel was synthesized by gamma irradiation for the expulsion of phosphate ions from wastewater. Chemical adjustment of the hydrogel with thiourea was performed to introduce thiol groups Cs/Gltn/PDMAEMA-treated. More over trapping of SiO2 into the hydrogel matrix to acquire Cs/Gltn/PDMAEMA/SiO2 composite. It was found that the gelation increases with increasing PDMAEMA content in the hydrogel. The maximum gelation performed at an equal ratio of Cs/Gltn at a radiation dose of 15 kGy. The adsorption capacities of the prepared systems towards phosphate ions were investigated. It was obtained that the maximum removal is achieved at pH 6 through 180 min. However, the removal percent decreases with increasing phosphate ions concentration and temperature. The ability of the prepared adsorbents towards phosphate ions removal are ascending ordered in the sequence of Cs/Gltn/PDMAEMA hydrogel, Cs/Gltn/PDMAEMA-treated , and Cs/Gltn/PDMAEMA/SiO2 composite. The pseudo-second-order equation fits well the adsorption kinetics. The adsorption isotherm follows the Freundlich model higher than the Langmuir model
Adsorption
Composite
Hydrogel
phosphate removal
watertreatment
Chitosan
Gamma Irradiation
2019
08
01
1537
1549
https://ejchem.journals.ekb.eg/article_28584_d517486c21aa7131e5b3077ba470121d.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2019
62
8
Solvent Extraction Techniques of Lipid from Algal Species in Wastewater Treatment Station
Esraa
Ahmed
Sana
Abo Elenin
Asmaa
hamouda
Hamada
Mahamoud
Biodiesel production process relies of various key steps one of which is the lipid extraction from microalgae cells using economic techniques. In this study, Algal community structure and physicochemical parameters of the wastewater treatment plant (Beni-Suef, Egypt), are determined from March 2016 to February 2017. In this study, we focused on the lipid extracted from wild mixed culture of Chlorella sp. which is the dominant from December 2016 to February 2017. Lipid content and fatty acid profiling of Chlorella sp. are investigated using three different methods (1) conventional extraction (CE), (2) ultrasonic assisted extraction (UAE) and (3) microwave assisted solvothermal extraction (MASE). MASE showed the highest lipid yield of 37.9±0.13%. SEM micrographs showed that MASE had the most distributive effect for algae cells compared to UAE and CE. Six different solvents are tested for MASE technique namely hexane: isopropanol (3:2), hexane: ethanol (1:1), chloroform: methanol (1:1), diethyl ether, ethanol and methanol. A strong linear relation between the direct electric constant and yield percent is obtained with methanol showing the highest yield. The GC-analysis of extracted lipids shows that methanol resulted in the highest percentage of palmitic acid (45.5%). The chemical composition of extracted lipids shows promise towards further conversion to biodiesel.
solvent extraction
Lipids recovery
wastewater treatment plant
saturated fatty acid
Solvent polarity
GC analysis
2019
08
01
1551
1562
https://ejchem.journals.ekb.eg/article_28755_b93cd92f05b40bf146089ad75e143417.pdf