2024-03-29T14:30:46Z
https://ejchem.journals.ekb.eg/?_action=export&rf=summon&issue=307
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds
3-(3,4-DICHLORO (or 3,4-dimethyl)benzoyl)] prop-2-enoic acids 1 ..... react with o-xylene and p-xylene under Friedel-Craft's reaction conditions giving acids 2 or 3, respectively. They were converted into the corresponding pyridazinone 4 derivatives upon treatment with N2H4 in boiling ethanol . The pyridazine derivatives 9,10,11 can be synthesized as a pro-drug due to their more potent and less peripheral effects than non-acidic or weakly acidic NSAIDs. Also, triazolopyridazine, oxazinone and furanone were also investigated.
3-Aroylprop-2- enoic acids
Pyridazinone
Triazolopyridazine
furanone
Pyridine
Oxime and Oxazinone
2012
10
01
579
593
https://ejchem.journals.ekb.eg/article_1427_613ca974ffc4c1363f54bcdd3a3f634a.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Synthesis of Some New Pyrimidines and Pyrrolo [2,3-d] Pyrimidines as Potential Antimicrobial Agents
CYCLOCONDENSATION reaction of compound 1 with oxalyl
choloride in acetone and dimethyl formamide afforded pyrrolo
[2,3-d] pyrimidine derivative 2 , which was reacted with p-amino
acetophenone, p-aminobenzenesulfonamide (sulpha drugs), thiosemicarbazide
, ethyl chloroacetate and benzoyl acetonitrile to give
compounds 3, 4a-c, 5, 6, and 7, respectively. Condensation reaction of
acetyl derivative 3 with 3, 4, 5-trimethoxybenzaldehyde afforded
compound 8. 2(1H)-pyridone and imino pyridine derivatives 9, 10 were
obtained by the reaction of compound 8 with ethyl cyanoacetate or
malononitrile in presence of ammonium acetate. Moreover, chalcone
derivative 8 was condensed with thiourea to give compound 11. Michel
condensation reaction of 3 with ethyl cyanoacetate and 3-
indolcaroxaldehyde leads to the formation of the pyridine 12 in one step
reaction. Bromination of compound 13 afforded 14, which was reacted
with thiourea to give compound 15. Furthermore, compound 13 was
allowed to react with hydroxyl amine hydrochloride and phenyl
hydrazine to give compounds 16 and 17, respectively. The antimicrobial
activity of some of synthesized compounds was evaluated.
Pyrimidine
Pyrrolo [2
3-d] pyrimidine derivatives
Condensation reaction
Cyclization and Antimicrobial activity
2011
10
31
595
608
https://ejchem.journals.ekb.eg/article_1428_dea24f2c3952ccf6989f0c0f94b567d6.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones
3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with .......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.
α
β-Unsaturated ketones
1
5-Diketones
Nicotinonitriles
pyrazole
Isoxazole
Pyran and pyridine derivatives and Antimicrobial activity
2011
10
31
609
622
https://ejchem.journals.ekb.eg/article_1429_eb7783db5df9e8ca778905ce08621e91.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Infrared Absorption Spectra of Some Gamma Irradiated Borate Glasses Containing Nickel and Titanium Ions
INFRARED absorption spectroscopy for a number of borate number of borate glasses containing nickel and titanium nickel and titanium ions was carried out before and after subjecting to gamma radiations. All glasses were melted in Pt-2% Rh crucibles in an electrically heated furnace at 1100°C for two hours.
All measurements were recorded using a Jasco FT/IR-300 E infrared spectrophotometer in the range of (4000-200) cm
-1.
The response of the glasses studied to γ-rays radiation is related to the formation, accumulation and annihilation of induced defects and hence the observed changes in the FTIR spectra can be utilized to confirm the changes in the structure arrangements of the building groups after irradiation.
2011
12
31
623
637
https://ejchem.journals.ekb.eg/article_1430_6af509893187cf7af7bcaab0ba9cffb5.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Reaction of 1, 3-Di-(1-piperidyl)-2-nitropropane with Thiophenol and Hydrogen Sulfide and Preparation of 5-Nitrohexahydropyrimidin-2-thione
THE CHEMISTRY and biological activities of Mannich bases …….have received considerable interest. The alkylation of amines, active methylene compounds and thiols with Mannich bases has been the subject of extensive studies as the products are of considerable synthetic and pharmaceutical interest.
2011
12
31
639
646
https://ejchem.journals.ekb.eg/article_1431_ac19feeb58dc02fcdd3f7c6cc644f49e.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Characterization of Synthesized Phenylthiazoly-liminomethyls and Some Metal-Complex Derivatives Irradiated with γ-Rays
Treaction between the amine, 2-amino-4-phenylthiazole and the aldehydes salicylaldehyde and o-phthalaldehydic acid, respectively in 1:1 molar ratio. The metal-complex derivatives of Fe3+, Co2+, Ni2+, Cu2+, Zn 2+ and La3+ were also prepared for each ligand. The elemental analysis, IR, UV-Visible, 1H NMR and MS spectral analyses served the structure elucidation.
The products were γ-irradiated and the post-radiation UV-Visible results were studied. Some radiolysis products were suggested with the assistance, of the obtained MS results. The TGA events described the thermal stability and coordination establishment of the metal derivatives.
In association with the UV-Visible data and magnetic behavior of metal- complexes, the octahedral geometry was suggested for most of the investigated products. However, Cu-complexes revealed distorted arrangement. Most of the derivatives exhibited low molar conductance values illustrating the association of amines in the coordination sphere and the non-electrolyte behavior.
The antimicrobial activity tests showed significant inhibition against the Gram-positive
Bacillus subtilis (NCTC-1040) by the Cu-complexes. Nevertheless, only the Cu-complexes of II displayed similarly against Streptococcus pyogens (ATCC-19615). The Co- complex of II revealed also significant inhibition against the Gram-negative E.coli as well as against the fungus Aspergillus fungatus .
Schiff-base
metal-complex
spectral analysis
-Irradiation and Antimicrobial activity
2011
12
31
647
662
https://ejchem.journals.ekb.eg/article_1432_0396f747a2e9ffc05ef25a543ec411e6.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Eco-Friendly Technology for Textile Printing Using Innovative Self Printing Paste
TARA SEEDS were subjected to mechanical crushing sieving and soaking in water followed by filtration to obtain galactomannan gum. Rheological properties of this gum were investigated before and after the gum was treated with sodium hydroxide (0. 5 to 10%).
Experience gained from this study was used to concurrently isolate eco-friendly galactomannan gum and safety natural dye from Tara seeds in one step process. Evaluation was made of the obtained self printing paste for printing cotton, wool and silk fabrics in presence and absence of different mordants. It was found that pastes of Tara gum treated with sodium hydroxide at a range of 0.5 to 2 % exhibit non-Newtonian pseudo plastic behavior, whereas the latter is converted at higher alkali concentrations to non- Newtonian Thixotropic behavior; similar to pastes prepared from the untreated gum. The colored printing paste, which was isolated from Tara seeds, could successfully be used in printing of silk, wool and cotton fabrics without any additives, but the shade was only confined to one color. It was also found that the K/S values of silk and wool are practically equal meanwhile they are higher than that of cotton. Mordants enhance printing and create different colors, depending upon their nature. For example the K/S of printed cotton samples displays the highest value with tannic acid and the lowest with alum and follows the order: tannic acid > copper sulphate > ferrous sulphate > potassium dichromate > alum ; an order which is also valid for wool and silk fabrics.
Fabrics printed by the self printing paste acquire color fastness to rubbing, to washing, and to perspiration ranging from very good to excellent, besides, resistance of the prints to alkali treatment.
Tara gum
Self printing paste
Mordants
Cotton
Wool and Silk
2011
12
31
663
678
https://ejchem.journals.ekb.eg/article_1433_d54e0d4ebb65d2352b1874327c21549e.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Functionally Substituted 1,2,4-Triazoloquinoline, Tetrahydro-quinolinone and Benzotriazolotriazine Derivatives from 5,5-Dimethylcyclohexan-1,3-Dione and Arylmethylenemalonic Acid Derived Michael Acceptors
SEVERAL new functionally [1,2,4]triazolo[1,5-a]quinoline-4- …… carbonitriles (8a-c) and [1,2,4] triazolo[1,5-a]quinoline-4-carbox-amides 12a,b were prepared from Nʹ-(5,5-dimethyl-3-oxocyclohexen-1-yl)benzohydrazide (5) and arylmethylene nitriles 2a-c and 2d,e, respactively.Reacting 2-oxo-3H-indol-3-ylidene malonic acid derivatives 3a,b with 5 afforded dioxospiro [3H-indole-3,4ʹ-quinoline]-3ʹ-carbonitrile (15) and 2- oxo-[1H] indol-3-ylcyanoacetate (17), respactively.Treating 5 with the enaminoester 18 gave hexahydro-7,7-dimethyl-2,5-dioxoquinolin-3-yl]benzamide (20). Coupling of 5 with the aryl diazonium salts and heteroaryl diazonium salts gave the hydrazones (21) and tetrahydro-[1,2,4]triazolo[5,1-c] [1,2,4] benzotriazine-6-ylidene)benzohydrazide (26).
2011
12
31
679
690
https://ejchem.journals.ekb.eg/article_1434_8226e0274cf208fb64b25bc29e6a22a5.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines
ASERIES of new 6,7,8,9-tetrahydrodibenz[ b,f][1,4]oxazepin-11(10H)-ones (3) was prepared by alkylation of salicylamides 1 with 2-chlorocyclohexanone followed by cyclodehydration of the resulting 2-cyclohexyloxybenzamides 2. New pyrido [2,3-b] [1,4]benzoxazepin-6(5H)-ones (8) were prepared by reacting salicoyl chlorides 4 or their corresponding acids 5 with 3-amino-2-chloropyridines 6 followed by treatment of the resulting amides 7 with sodium methoxide. Some of the new compounds were subjected to preliminary screened for their tranquilizing effect.
Dibenz[b
f][1
4]oxazepin-11(10H)-ones
Pyrido [2
3-b] [1
4] benz- oxazepin-6(5H)-ones
Tranquilizers and Diazepam
2011
12
31
691
701
https://ejchem.journals.ekb.eg/article_1435_227b6e4db5fb7508040d6b4cc989e3ad.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
54
5
Studies on Substituted Heteroarenes: New Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo[4,3-bpyridine, Pyrano [3,2-c]quinoline, Benzo [f] chromene, Benzo[h] chromene, Chromeno [8,7-h]chromene, Chromeno[6,5-f] chromene and 2H-chromene Derivatives
SEVERAL new pyrazolo[4,3- b] pyridines )7a,b( were prepared by reacting arylmethylenenitriles )1a,c or 1i,j( with 4-nitrosoantipyrine )4(. Reacting 1a,b,d with 4-azidomethylcarbonylantipyrine 8 gave 2-aminopyrrole (14). Pyrano[3,2-c] quinolines (20a,b and 23) were obtained by reacting 4-hydroxyquinoline (15) with 1g, h;2b, respectively.Reaction of 1 with naphthalenediols 24,27 and 29 yield naphthodipyrans 26a,b,28a,b and 30a,b, respectively. Spironaphthodipyrans (32,33) and spironaphthopyrans (36,37) were prepared through reaction of 2a with naphthalenediols (24,27,34 and 35), respectively. Condensation of thioxothiazole (38) with 3,5-dibromo-2-hydroxybenzaldehyde gave 2H-chromene-3-carboxamide (42). 38 also reacted with 1c and 2a to gave 3,5-dicyanopyridines (45 and 47), respectively. Reaction of 2-cyano-N`-(1-thiophen-2-yl)ethylidene) acetohydrazide (49) with 1a,b afforded 3,5-dicyanopyridines (53).
2011
12
31
703
721
https://ejchem.journals.ekb.eg/article_1436_fb14e259d21314d49c30eddd90a7508b.pdf