2024-03-29T00:24:11Z
https://ejchem.journals.ekb.eg/?_action=export&rf=summon&issue=279
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Utility of 4-(4-Bromophenyl)-4-oxo-but-2-enoic Acid in Synthesis of Some Important Heterocyclic Compounds
THE PRESENT work deals with the generation and synthesis of different heterocycles
via the treatment of 3-(4-bromobenzoyl) prop-2-enoic acid (1) with thiourea, ethylcyanoacetate malononitrile & acetylacetone in presence of amm.acetate and / or piperidine , 2-amino-5-phthalimidomethy l1,3,4-thiadiazole, methyl thioglycolate 4-bromoaniline and ethylacetoacetate to afford Michael and aza-Michael adduct that cyclized by hydroxyl amine and hydrazine hydrate, respectively. Additionally, utility of 2-(2-amino-5-phthalimidomethyl 1,3,4-thiadiazol-2-yl)-4-(4-bromophenyl)-4-oxo-butanoic acid (4) as a key starting material to synthesize some important heterocycles include fused oxoimidazolo [2,3-b]-1,3,4-thiadiazole.
4-Bromophenyl-4-oxo-2-butenoic acid
Pyridine
Pyrimidine
Phthalazinhydrazone
Benzisoxazolone
Phthalimide
Thiadiazole imidazolothiadiazole and Pyridazinone
2012
02
28
1
13
https://ejchem.journals.ekb.eg/article_1127_60147b2643d02090412cdfd0b465ddf3.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex
Smagnetic resonance in combination with thermal analysis measurements were used to verify and describe the physicochemical properties of the synthesized moxifloxacin (MOX) Zirconium (IV) metal complex. The spectroscopic and elemental analysis data support the formation of the complex with the formula C21H23FN3O4Zr(H2O)2.0.5H2O. Results revealed that complexation between Zirconium (IV) and moxifloxacin exhibited significant increase in antibacterial activity especially against Gram negative organisms. In addition, a simple, rapid, reliable, and sensitive spectrofluorometric method is developed for the determination of MOX. The method depends on the chelation of MOX with zirconium (IV) to produce fluorescent chelate (MOX/ Zr). Different factors affecting the relative fluorescence intensity of the resulting chelate were studied and optimized. The relationship between the concentration and relative fluorescence intensity was rectilinear in the range of 0.1–4 μg/ml. The limits of detection and quantitation are 0.06 and 0.11 μg/ ml, respectively. At the optimum reaction conditions, the drug–metal chelate showed excitation maximum at 333 nm and emission maxima at 485nm. The developed method was applied successfully for the determination of the studied drug in its pharmaceutical dosage forms with a good precision and accuracy.
Moxifloxacin
Metal complexation
Spectrofluorometric
Thermal analysis and Antibacterial
2012
02
28
15
31
https://ejchem.journals.ekb.eg/article_1128_6f0eed43aa860f36287f7ae89ab11245.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Synthesis of Core/Shell Nano Finish for Antimicrobial Cotton Fabrics
SILVER loaded chitosan /methoxy polyethylene glycol chloro ……triazine (Ag/chit-MPEGT) core/shell nano particles were synthesized as a durable finish for cotton fabrics. Ag/chit-MPEGT was firstly synthesized by reaction of silver loaded chitosan (Ag-chit) with methoxy polyethylene glycol dichlorotriazine. The latter was prepared by reaction of MPEG with 2,4,6-trichloro-s-triazine in acetone and sodium carbonate. Silver loaded chitosan(Ag/chit) nanoparticles were prepared by Ionotropic gelatin method. The resulting Ag/chit-MPEGT core/shell nano-particles were characterized by IR-spectra, 1H NMR spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM) and elemental spectroscopy imaging (ESI). The cotton fabric is treated with the prepared core/shell nanoparticles using the conventional and convenient pad-dry-cure techniques to impart the durable antimicrobial properties. Citric acid was used as a crosslinking agent to improve the morphology, the crease resistance and the durable press finishing of the treated fabric. The latter was tested for the fabric surface morphology, crease resistance, break tensile strength, elongation–at-break, air permeability and antimicrobial activity.
2012
02
28
33
56
https://ejchem.journals.ekb.eg/article_1130_d1030c34793bd2c93e4f07883022bffc.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
New Palladium (II) Complexes Bearing Benzopyran Derivative Ligands: Synthesis and Characterization
PALLADIUM complexes of (4-methoxyphenyl benzopyran, 4- fluorophenyl benzopyran and 4-(2 -chloro-5-nitro) phenyl benzopyran ligands) have been synthesized and characterized using different tools such as IR, UV/Vis, 1H-NMR, elemental analysis, thermal analysis, and mass spectroscopy. The mode of binding Pd (II) ion with the ligands shows that the Pd (II) ion binds with the ligands through the amino group nitrogen atom and cyanide group nitrogen atom of the ligands which revealed a square-planar coordination geometry at the metal center [Pd L1.2Cl] 0.5H2O,[Pd L2 .2Cl] 1.5H2O and [Pd L3 .2Cl].
2012
02
28
57
72
https://ejchem.journals.ekb.eg/article_1131_06178b030d3301aeb342e042f8746248.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Effects of River Inputs on Mediterranean Coastal Shore Line in front of Damietta Estuary
THE WATER quality characteristics and some heavy metals cations (Fe2+, Mn2+, Zn2+, Cu2+ and Pb2+) of Damietta estuary and in front of Mediterranean coastal shoreline were evaluated through four successive cruises (February 2008 to November 2008). Twelve sites were selected from the two sectors. The results obtained showed that serious deterioration of quality of water at Damietta estuary compared with Mediterranean shoreline. The concentrations of major cations and anions increased progressively while moving away from Damietta Estuary to the sea which reflect the effect of seawater intrusion into estuary. Contrarily, nutrient salts values in the estuary showed elevated values due to heavily polluted waste water poured into estuary where the nutrient salts content of the Mediterranean Sea water depend on its levels in Damietta Estuary. The distribution order of heavy metals concentrations in water samples was Fe > Mn > Pb > Zn > Cu > Cd.
2012
02
28
73
84
https://ejchem.journals.ekb.eg/article_1132_b76fd6834d8279b9b8bedf7a055c52f5.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Fabrication and Characterization of Nano-Hydroxyapatite\ Chitosan Biocomposites with and without Citric Acid Addition
BIOCOMPOSITES composed of carbonated apatite and chitosan in ….. the presence or absence of citric acid were fabricated through a co-precipitation method. The prepared biocomposites were characterized by Fourier transformed infrared spectroscopy (FT-IR), X- ray diffraction (XRD), Thermo gravimetric analysis (TGA), Transmission electron microscopy (TEM), and Scanning electron microscopy (SEM). The results proved that the presence of citric acid in the composite accelerated HA formation and reduced its particle size. Also, the compressive strength increased for HA/chitosan composite compared to HA alone and more increased with addition of citric acid which enhanced the binding strength between HA particles. The HA/chitosan composite with ratio 70% HA and 30% chitosan, especially with citric acid, may be promising for bone grafting and bone tissue engineering applications.
Apatite
Chitosan
Biocomposites
Citric acid and TEM
2012
02
28
85
97
https://ejchem.journals.ekb.eg/article_1134_714c43f6a08567098e45fdc47118da70.pdf
Egyptian Journal of Chemistry
Egypt. J. Chem.
0449-2285
0449-2285
2012
55
1
Synthesis of Some Heterocyclic Molecuoles from New Benzoxazinones and Quinazolinones
THE BENZOXAXAZINONE 3 was prepared and treated with
…... hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine to give different quinazolinones 4,5 and benzoimidazoles 6, 7, respectively.Product 4 reacted with different aldehydes forming different Schiff’s basses 9,10a - e. Also, it reacted with different Grignard reagents giving alcohols(11a,b) and ketones 11c,d, according to the bulkiness of the reagent. Finally, dibromo, monobromoamino and diaminoquinazolinones (12,13 a-d) & (14 a-d) were prepared upon addition of bromine to 4, followed by reacting different amines according to their molar ratios. Some benzoxazinone, and quinazolinone derivatives were tested for their antifungal and antibacterial activities and gave promising results.
Quinazolinones
Benzoxazinones and Schiff’s base
2012
02
28
99
110
https://ejchem.journals.ekb.eg/article_1135_3a1c22d9083ae199826b5b07bd7dc48d.pdf