TY - JOUR ID - 217683 TI - In Vitro Evaluation Of Antioxidant And Cytotoxic Activity Of Isolated Compounds From Pittosporum Eugenioides JO - Egyptian Journal of Chemistry JA - EJCHEM LA - en SN - 0449-2285 AU - Hamed, Manal Mortady AU - Refahy, Lailal Abdel-Ghany AU - Shafei, Azza Abbas AU - Abd El Aziz, Eman Gamal AD - Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt AD - Medicinal Chemistry Department, Theodor Bilharz Research Institute (TBRI) AD - Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt AD - Sheben Elkom Hospital, Menofiya, Egypt Y1 - 2022 PY - 2022 VL - 65 IS - 10 SP - 321 EP - 328 KW - Pittosporum eugenioides KW - Antioxidant activity KW - Cytotoxic activity KW - (DPPH) KW - Artemia salina L DO - 10.21608/ejchem.2022.117564.5311 N2 - Ten compounds were isolated from the n-butanol extract of Pittosporum eugenioides leaves and evaluated for their antioxidant properties and cytotoxic activity. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical using ascorbic acid as standard antioxidant and total antioxidant capacity (TAC) (phosphomolybdenum assay). The overall antioxidant activity of compounds 1, 2, 3 and 4 showed the strongest one among the tested compounds with values of 1.28±0.97, 3.21±0.24, 5.40±0.08 and 7.09±0.07 μg/ml, respectively compared to the SC50 value of the positive ascorbic acid control was 7.9±0.78 μg/ml. Also, these compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina L.). The LC50 values ranged between 11 to 25 μg/ml, for the compounds 1-10. The present study reveals that the selected plants would exert several beneficial effects by virtue of their antioxidant and cytotoxic activity and could be harnessed as drug formulation. UR - https://ejchem.journals.ekb.eg/article_217683.html L1 - https://ejchem.journals.ekb.eg/article_217683_e07689c3d77c666a4723ea8206cf93e9.pdf ER -