TY - JOUR ID - 217575 TI - Preparation of poly (N-vinyl-2-pyrrolidone)/ammonium persulfate hydrogel embedded silver nanoparticles JO - Egyptian Journal of Chemistry JA - EJCHEM LA - en SN - 0449-2285 AU - Fahmy, Hesham AU - Okda, hager AU - Amr, Ahmed AD - Textile Research and Technology Institute, National Research Center, Dokki, Giza, Egypt Y1 - 2022 PY - 2022 VL - 65 IS - 9 SP - 37 EP - 45 KW - Hydrogel KW - poly (N-vinyl-2-pyrrolidone) KW - Drug Release KW - Silver nano particles DO - 10.21608/ejchem.2022.116818.5276 N2 - The current study aims to synthesis crosslinked poly (N-vinyl-2-pyrrolidone) (CPVP) and poly (N-vinyl-2-pyrrolidone) containing silver nanoparticles (CPVP/Ag-NPs) hydrogels using ammonium persulfate (APS) as an initiator and silver nitrate as a precursor. Factors affecting crosslinking of such matrices were studied. The results obtained revealed that the optimum reaction conditions to prepare CPVP were: PVP concentration (70%), PVP molecular weight (40000 Dalton), APS/PVP weight ratio (100%), reaction temperature (90 OC), and reaction time (40 min). The aforementioned synthesized hydrogels were characterized via IR, XRD, SEM, as well as EDX analysis. The results confirmed that such prepared gels have remarkable antibacterial properties. The UV–Vis absorption spectrum proved that Ag-NPs were formed during CPVP synthesis. The release profiles of sodium diclofenac form the CPVP gel at pH 4 and 7 were studied. UR - https://ejchem.journals.ekb.eg/article_217575.html L1 - https://ejchem.journals.ekb.eg/article_217575_2de34edf5a99e068380ecbe21db7b670.pdf ER -