TY - JOUR ID - 205619 TI - Synthesis, and Biological Studies of New Azo–azomethineCompounds Based onSulfathiazole and Sulfadiazine JO - Egyptian Journal of Chemistry JA - EJCHEM LA - en SN - 0449-2285 AU - al-hilfi, dhuha asaad AU - jadou, bushra kamel AD - chem.dept.college of science.basrah university AD - basrah university-IRAQ Y1 - 2022 PY - 2022 VL - 65 IS - 5 SP - 337 EP - 345 KW - Antibacterial KW - antioxidant KW - azo- azomethine KW - Sulfathiazole KW - Sulfadiazine DO - 10.21608/ejchem.2021.100924.4690 N2 - Two new series of azo-azomethine compounds based on sulfathiazole and sulfadiazine were synthesized. Condensation of sulfathiazole diazonium salt and sulfadiazine diazonium salt with 3-ethoxy-4-hydroxy benzaldehyde. These new azo compounds were reacted with sulfathiazole, sulfadiazine,3-hydroxy aniline, 2-amino-4,6-dimethyl pyridine, and 4-bromoaniline respectively, to form the new azo-azomethine compounds. All compounds were characterized by CHN analysis, IR, 1H NMR, and mass spectroscopic data. Antibacterial activities were studied for these compounds in‐vitro and showed some promising activity against Escherichia coli and Staphylococcus aureus. The antifungal activity against Candida albicans and Aspergillus niger was studied and showed good activity. The antioxidant activity was evaluated by using antioxidant tests via the free radical scavenging (DPPH) method and showed good antioxidant activities. UR - https://ejchem.journals.ekb.eg/article_205619.html L1 - https://ejchem.journals.ekb.eg/article_205619_93c0e73615bc51fb40132fb83cc97973.pdf ER -