National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate
777
790
EN
10.21608/ejchem.2010.1263
<span style="font-size: xx-small;">ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate or formamide afforded -2- propylquinazolin-4(3H)-one (3). Behaviour of quinazolinone towards carbon electrophiles namely, aromatic aldehyde, chloroacetylchloride, and ethylchloroacetate has been investigated and all the synthesized compounds were tested as anti-cancer in National Cancer Institute (NCI) in USA. </span>
Benzoxazin-4-one,Quinazolin-4(3H) one and Anthranil
https://ejchem.journals.ekb.eg/article_1263.html
https://ejchem.journals.ekb.eg/article_1263_2a1db490356d4e65980ef0045f523a36.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Can HCV RNA Be Detected in Saliva of Egyptian Children Receiving Frequent Blood Transfusions?
791
802
EN
10.21608/ejchem.2010.1264
HEPATITIS C virus (HCV) infection is considered a major public health problem all over the world, especially in Egypt. Blood is almost the only route for HCV diagnosis. It has been reported that HCV could be detected in body fluids including saliva which represents an easier route than blood especially in infants and children. This study aimed to: 1) Assess the prevalence of HCV infection among high risk group of Egyptian children. 2) Evaluate the detection of HCV antibodies (anti-HCV) and HCV RNA in saliva against their detection in serum among HCV positive children. <em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">Patients and methods</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">: this study included 200 children (92 males and 108 females) who were attendants of Haematology Clinic at Abu El-Reish Hospital, Faculty of Medicine, Cairo University, they were receiving frequent blood transfusions during their treatment. Serum and saliva samples were analyzed for detection of anti-HCV by ELISA technique and for HCV RNA by a home made RT-PCR method. Liver function tests were performed also. Results of serum samples revealed that 134/200 (67%) children were anti-HCV seropositive, out of them 79/134 (59%) children had HCV RNA in their sera. Saliva samples of HCV infected children (n=79) showed that 53/79 (67.1%) and 31/79 (39.2%) were anti -HCV and HCV RNA positive, respectively. Prevalence of HCV infection was 39.5% of 200 studied children. We can conclude that: 1) Prevalence of HCV infection among the studied children is considered high. 2) Saliva could play a possible role of biological fluids as a non parenteral route of intrafamilial spread of HCV infection. 3) More sensitive techniques could be developed to use saliva as a reliable route for HCV detection.</span></span>
HCV,PCR and Saliva
https://ejchem.journals.ekb.eg/article_1264.html
https://ejchem.journals.ekb.eg/article_1264_826e9505559aef71a31a99f179806247.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
New Purine Derivatives of Potential Plant-Growth Regulating Properties
803
820
EN
10.21608/ejchem.2010.1265
2-(CHLOROMETHYL)-purine-6(9 <em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">)-one (3) was synthesized from reaction of the 5-amino-imidazole-4-carboxamide 1 with 2-chloroacetyl chloride. Also, products 4-7 were obtained from reacting 3 with different reagents. Treatment of 1 with ethyl chloroformate / DMF reagent mixture afforded 9-aryl-1,9-dihydro-6</span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">H</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-purin-6-one (9). Product 9 when reacted with some alkyl iodides gave 7-alkylpurinium iodide salts (10) rather than the expected products of type 11 </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">or </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">12. </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">N</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-substituted </span></span><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA"><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA">– </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">purin -6- amines 14a-g, </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">N</span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-(purin-6-yl) - benzene-1,2-diamine 14h and hydrazide 14i were synthesized upon treating product 9 with phosphoryl chloride followed by reaction with some selected amines </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">or </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">hydrazides . Screening for selected examples from the synthesized products 14 towards wheat plant growth regulation was reported.</span></span>
6-Substituted-amino purines,Purinium iodide salts and Plant growth regulators
https://ejchem.journals.ekb.eg/article_1265.html
https://ejchem.journals.ekb.eg/article_1265_edacabc4aa817c6b023bf26134fcc873.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Synthesis, Spectroscopic and Biological Characterization of Cr(III), Mn(II), Co(II), Ni(II) and Cu(II) Complexes with New Macrocyclic Tetradentate [N4] Schiff Base Ligands
821
845
EN
10.21608/ejchem.2010.1266
THE SYNTHESES of three novel tetradentate Schiff base ligands, <em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">i.e. </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">L</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">= BBICI = benzo [1",2"-2,1] benzo [1"',2"'-8,7] indolo [3',2'-4,5] cyclododeca [10,11-b] indole, L</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">= DBBICI = 4, 13 </span></span><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA"><span style="font-family: Times New Roman; font-size: xx-small;" lang="JA">– </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">dimethylbenzo [1",2"-2,1]benzo [1"',2"'-8,7]indolo[3',2'-4,5] cyclo- dodeca[10,11-b]indole and L</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">3</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">=HHPPA= 10, 11, 12, 23, 24, 25-hexahydrophenanthro [9,10-a] phenanthro [9,10-h] [14] annulene and their novel complexes with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Cd(II) have been reported. The complexes are characterized by the elemental and thermal analyses, molar conductance and magnetic susceptibility ,</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">HNMR, IR and UV-Vis spectral also were studied. Cr(III), Mn(II), Co(II), Ni(II), Cd(II) and Cu(II) chloride and nitrate complexes have octahedral geometries while Cu(II) acetato complex has distorted octahedral leading to tetragonal geometry. The biological activities of the ligands and complexes have been screened </span></span><em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">in vitro </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">against some bacteria and fungi to investigate their capacity to inhibit their growth.</span></span>
Macrocyclic complexes,Schiff bases,Transition metals complexes,and Microbiological activity
https://ejchem.journals.ekb.eg/article_1266.html
https://ejchem.journals.ekb.eg/article_1266_23d95bc65c453df457bcac21ed6277e9.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Physical Modification of Lyocell® and Modal® Fabrics and its Effect on Fabric Dyeability
847
869
EN
10.21608/ejchem.2010.1267
THE EFFECT of some swelling agents; Viz. alkali metal hydroxides, alkaline earth metal salt and heavy metal salt, on the dyeability of lyocell and modal fabrics with reactive and direct dyes was monitored. The dyeing characteristics; namely colour strength, dyeing isotherm, diffusion coefficient, dyeing rate constant and half dyeing time of the dyed fabrics were assessed. The colour strength of the dyed samples increased in the order ZnCl <span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">> MgCl</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">2</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">> NaOH > KOH > untreated. The fastness properties of the dyed fabrics were investigated. X-ray diffraction patterns of both untreated as well as treated fabrics were used to assign the change in the fine structure of the swollen lyocell and modal fibres relative to their respective untreated ones. The water retention capacity of lyocell and modal fabrics was calculated to deduce the degree of crystallinty of treated as well as untreated lyocell and modal fabrics.</span></span>
Lyocell,Modal,swelling,dyeing,Reactive,Direct and X-ray
https://ejchem.journals.ekb.eg/article_1267.html
https://ejchem.journals.ekb.eg/article_1267_0e1f8317cc10ac2b0f64ee13f5041d1d.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Kinetics of Thermal Decomposition of Iron Carbonate
871
884
EN
10.21608/ejchem.2010.1268
<span style="font-size: xx-small;">THE THERMAL decomposition of iron cabonate in air was ……studied by means of DTA-TG, XRD, SEM and Mossbauer measurements. The kinetics of the thermal decomposition process were studied using isothermal and non-isothermal thermogravimetric techniques. The results show that the thermal decomposition proceeds in one step to iron oxide. Kinetic analysis of isothermal data of the decomposition reaction in the light of various solid state reaction models revealed that the reaction is best described by the diffusion models. Kinetic analysis of the dynamic TG curves were discussed with reference to Diefallah’s composite integral method, in comparison with the integral methods due to Coats-Redfern and to Ozawa. The activation parameters were calculated and the results of the isothermal and dynamic integral methods which were compared to each other were discussed. </span>
https://ejchem.journals.ekb.eg/article_1268.html
https://ejchem.journals.ekb.eg/article_1268_82097e00ce1c4e475f17cfec61edb6d2.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Rapid and Simple Spectrophotometric Determination of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) Ions in Natural Samples Using 2-(2-Hydroxynaphth-1-ylazo)-pyridine
885
902
EN
10.21608/ejchem.2010.1269
THE MEDIUM effect on the electronic absorption spectra of 2-(2-hydroxynaph-1-ylazo)-pyridine (HL) was studied. 2-(2-hydroxynaph-1-ylazo)-pyridine has been found to be a good chromogenic reagent for determination of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) ions. In aqueous buffer solution of different pH values (2-12) containing 30 % (v/v) methanol-water, HL reacts with Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) ions to form 1:1 and 1:2 (M:L) chelates. The formed complexes exhibiting absorption maxima at 580, 555, 577, 561 and 551 nm with apparent molar absorptivities 2.42 x 10 <span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;">4</span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">, 0.58 x 10</span></span><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;">4</span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">, 2.14 x 104, 4.54 x 10</span></span><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;">4 </span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">and 2.09 x 10</span></span><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ff0000; font-family: Times New Roman; font-size: xx-small;">4 </span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">(L mol</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1 </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">cm</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">-1</span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">) for Mn(II), Fe(III), Co(II), Ni(II) and Cu(II)-complexes, respectively. The optimum conditions (pH, time, temperature, reagent concentration, sequence of addition and solvent ratio) for chelates formation are studied. The spectrophotometeric analytical characteristics (linearity ranges, Ringbom ranges, stability constants and free energy changes) of the formed complexes are determined. Relatively large amounts of co-existing elements, including all other metals, can be tolerated. The advantages of this method are: simple and rapid, with high sensitivity and good selectivity and was applied to the determination of the mentioned metal ions in natural samples with satisfactory results. Some solid HL-complexes are prepared and studied by different analytical and spectral techniques in order to investigate the mode of bonding in the formed complexes.</span></span>
2-(2-Hydroxynaph-1-ylazo)-pyridine,Mn(II),FE(III),Co(II),Ni(II),Cu(II) determination
https://ejchem.journals.ekb.eg/article_1269.html
https://ejchem.journals.ekb.eg/article_1269_3daea7301f8532ba5554fae84c5cd15e.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Synthesis of Eco-Friendly Binders from Natural Resources Using Microwave and their Applications in Textile Printing
903
921
EN
10.21608/ejchem.2010.1270
<span style="font-size: xx-small;">DIFFERENT oil length alkyd resins based on sunflower were ........prepared using microwave heating .the effect of oil length as well as using different catalysts on the .properties of alkyd resin such as acid value, Tg, solubility and IR data were evaluated. In case of using microwave heating the formation of alkyd resin occurred after 45-60min, while on using conventional heating the reaction duration ranged from 8-10 hr. Also, the prepared alkyds and commercial binder were used separately in the formulation of pigment printing pastes, and the properties of printed fabrics using the prepared binders were found to be comparable with samples printed using the commercial binder. </span>
microwave,Binder,Textile printing and Alkyd resins
https://ejchem.journals.ekb.eg/article_1270.html
https://ejchem.journals.ekb.eg/article_1270_d02a21f17f25bf8a3e1b1dd89ec17062.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Effect of Refining Processes on Magnitude and Nature of Fenitrothion and Pirimiphos-Methyl Residues in Maize Oil and Bioavailability of their Cake Residues on Rats*
923
938
EN
10.21608/ejchem.2010.1271
<span style="font-size: xx-small;">MAIZE seeds obtained from </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-fenitrothion or </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-pirimiphos-methyl treated maize plants contained about 0.12 % and 0.16 % of the originally applied radioactivity, respectively. The concentration of </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-fenitrothion residues and </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-pirimiphos-methyl residues in crude oil (hexane extract) ranged from 2.8-3.0 ppm, methanol solubles 2.3 ppm and in seed cake 1.2-1.4 ppm. Commercial processing procedures led to a gradual decrease in the total amount of </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-residues in oils with aged residues. The refined oil contained only about 13-19% of the radioactivity originally present. The deodorization and alkali treatment are the most effective steps as they removed over 50 % of the residues. Chromatographic analysis of refined oil revealed the presence of fenitrothion, 3-methyl-4-nitrophenol as main products beside smaller amounts of fenitrooxon and desmethyl fenitrothion. Whereas, pirimiphos-methyl and 2-diethyl-2-amino-4-hydroxy-6-methylpyrimidine were detected as principal compounds together with minor amounts of 2-ethyl-amino-4-hydroxy-6-methylpyrimidine and 2-amino-4-hydroxy-6-methyl-pyrimidine. </span>
On feeding rats with the extracted seeds (cake) for three days, the bound residues were found to be considerably bioavailable. A substantial amount of administrated bound
<span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-residues was eliminated via respiration (50%) for </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-fenitrothion and excreted urine (47%) for </span><span style="font-size: xx-small;">14</span><span style="font-size: xx-small;">C-pirimiphos-methyl. While feces contained only 10-12% and about 22-26% of the radioactive residues were distributed among various organs of experimental animals. </span>
14C-Fenitrothion,14C-Pirimiphos-methyl,Maize seed oil,Insecticide residues,Refining processes and Bioavailability
https://ejchem.journals.ekb.eg/article_1271.html
https://ejchem.journals.ekb.eg/article_1271_9f8f7d6340f6934bab3eb0e4f8c06d4a.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
53
6
2010
12
31
Synthesis of Highly Soluble Fluoro Containing Metal -phthalocyanines and (Hexafluoroisopropylidene) -bridged Metal-phthalocyanine Polymers
939
954
EN
10.21608/ejchem.2010.1272
<span style="font-size: xx-small;">NOVEL soluble peripherally tetrasubstituted metal-phthalocyanines: 2(3),9 10), ……16 (17),23(24) – tetrakis - 2'-(4-hexafluoroisopropylidene-phthalic acid)-phthalocyanines [(R</span><span style="font-size: xx-small;">4</span><span style="font-size: xx-small;">Pc)M] where R= (4,4`-(hexafluoroisopropylidene) bis-phthalic acid and M= Co(II), Ni(II) and Cu(II) 2-4, have been prepared. Additionally, the soluble hexafluoroisopropylidene bridged high molecular weight phthalocyanines 5-7 were obtained by controlling the reaction conditions such as molar ratio of the reactant, reaction time and temperature. Structural and spectral investigations (FAB-MS, MALDI-TOF-MS, </span><span style="font-size: xx-small;">1</span><span style="font-size: xx-small;">H-NMR, atomic absorption spectroscopy (AAS), elemental analysis, UV/Vis, FTIR, TGA, and GPC) of the prepared phthalocyanines revealed some interesting observations. </span>
Soluble phthalocyanines,Fluorine,Cobalt,Nickel,copper,(Hexafluoroisopropylidene) -diphthalic anhydride,Bridged phthalocyanine polymers
https://ejchem.journals.ekb.eg/article_1272.html
https://ejchem.journals.ekb.eg/article_1272_05e43b8f3ff2834fdef7ad2f33c5e0a5.pdf