ORIGINAL_ARTICLE
Synthesis of New Dipyrimidine and Dialkyl Terephthalate Derivatives from 2,6-Diphenyl-sulphonyloxy-1H, 3H, 5H, 7H-pyrrolo [3,4-F] isoindole- 1, 3, 5, 7-tetrone
THE TITLE compound 2 was obtained by treatment of 2,6-dihydroxypyromellitimide 1 with benzenesulphonyl chloride. Compound 2 was used as starting material for the synthesis of new dipyrimidine and dialkyl 2,5-di [(alkoxycarbonyl) amino] terephthalate derivatives. The reaction of 2 with different amines was intensively investigated with respect to the probability of isomerization.
https://ejchem.journals.ekb.eg/article_1102_fad473e2ac0370b050a32c416792ef5c.pdf
2013-04-30
111
126
10.21608/ejchem.2013.1102
5-Diaminoterephthalic acid diesters
2
6-Dihydroxy-pyromellitic imide
Lossen degradation and Pyrimidinediones
ORIGINAL_ARTICLE
Synthesis, Reactions and Characterization of 4,4’-Benzene-1,4-diylbis (5-Acetyl-6-methyl-2-thioxo - 1,2-dihydropyridine-3-carbonitrile)
BENZENE-1,4-dicarbaldehyde (1) reacted with 2-cyanoethane- …. thioamide (2) to give 3,3'-benzene-1,4-diylbis(2-cyanoprop-2-enethioamide) (3) which in turn, reacted with pentane-2,4-dione (4) to afford the corresponding 4,4’-benzene-1,4-diylbis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile)(5). The synthetic potentiality of compound 5 was investigated in the present study via its reaction with several reagents to afford newly synthesized 4,4’-(1,4-phenylene)-bis (5-acetyl-3-amino-6-methylthieno [2,3-b] pyridines (8a-h). Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses
https://ejchem.journals.ekb.eg/article_1103_be10e95f38e5f2ecacd989e35ef12985.pdf
2013-04-30
127
140
10.21608/ejchem.2013.1103
Bis(2-cyanoprop-2-enethioamide)
Pentane-2
4-dione
Bis (5-acetyl-6-methyl -2 -thioxo-1
2- dihydropyridine-3 carbonitrile)
Bis(5-acetyl-6-methyl-2-alkylthiopyridine-3-carbo-nitrile)
and Bis (5-acetyl-3-amino-6-methylthieno [2
3-b] pyridine
ORIGINAL_ARTICLE
Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)
THREE analogs of Bradykinin, (Cys6,8) BK, (Cys2,5) BK and (Cys1,9) BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of; Ser6 and Phe8 by Cys6,8, Pro2 and Phe5 by Cys2,5,and Arg1,9 by Cys1,9 on the biological activity of bradykinin was investigated. A continued work of a previously done study includes synthesis of three BK analogs, (Lys1) BK, (Lys9) BK and (Lys1, 9) BK, using the modified solid phase peptide synthesis with microwave energy. The six analogues have been tested in vitro for their effect on heart rate and in isolated organ for the arterial pressure of rats.
https://ejchem.journals.ekb.eg/article_1104_6ea7a4d837ea59b4c3c17af8fe5fd999.pdf
2013-04-30
141
153
10.21608/ejchem.2013.1104
Bradykinin
Modified solid phase peptide synthesis and Microwave energy
ORIGINAL_ARTICLE
Physicochemical and Fire Resistance Characteristics of Artificial Pozzolanic Cement Pastes
THE PRESENT work describes details concerning preparation and ….. physico-chemical characterization of pozzolanic cement pastes . The prepared cement pastes were examined by using XRD, SEM and nitrogen adsorption at-196oC. The results revealed that the physicochemical and mechanical properties of the solids investigated could be related to the microstructure and surface properties of the hardened pozzolanic cement pastes. It was found that the pozzolanic cement blend containing 20% Homera has the highest to fire resistance
https://ejchem.journals.ekb.eg/article_1105_0159f164168cd4247fbf07293cec66dc.pdf
2013-04-30
155
168
10.21608/ejchem.2013.1105
Ground clay brick
surface
Compressive strength and Fire resistance
ORIGINAL_ARTICLE
More Insight on Charcterization of Nano-sized Particles of Silver Powder and their Application in Antimicrobial Wound Dressing and Anti-inflammatory Efficacy
POWDERED silver nanoparticles (AgNPs) was successfully …….prepared.through addition of AgNO3 to alkali dissolved starch. The latter was used as eco-friendly biopolymers which played the dual role as reducing and stabilizing agent followed by precipitation with ethyl alcohol. The as prepared AgNPs powders have the smallest size (12-22nm), polydispersity (0.163) as well as zeta potential (-28mv) indicating higher surface area, the highly distributed nanoparticles as well as long-term stability of their product. These powdered AgNPs were re-dispersed in distilled water and diluted to different concentrations (250, 125 and 60 ppm). The diluted solution of AgNPs was applied to cotton fabrics as per the pad-dry-cure technique. The antimicrobial, wound healing, anti-inflammatory as well as toxicity of cotton fabrics loaded with these three different concentrations of AgNPs colloidal solution were evaluated. AgNPs in three different states, viz., in the powder form, in aqueous solution and deposited onto cotton fabrics were characterized using the world-class facilities such as UV-Vis spectroscopy, Transmission Electron Microscopy (TEM), Particle size analyzer, Polydispersity index (PdI), Zeta potential (ZP) and Scanning Electron Microscopy connected with Energy Dispersive X-ray (SEM-EDX). Cotton fabrics containing 250 ppm AgNPs were more effective against different species of microorganisms than those of dressing containing 60 and 125 ppm as indicated by the inhibition zone. Wound healing caused by dressing containing the highest content of AgNPs displayed the highest potent healing, with great similarity to the controlled cream (Dermazin). Moreover, the anti-inflammatory effect of 0.5 ml dose AgNPs (250 ppm) is nearly similar to 20 ml dose of the reference drug (indomethacin). Also reported was that, the Minimum Inhibitory Concentration (MIC) for the produced AgNPs on subsequent experiments was 10 μg/ml.
Silver was extensively used to control infections since ancient times. Nowadays, silver is finding wide- spread applications in medical domains
(1). Silver-based medical products were proven to be effective in retarding and preventing bacterial infections(2). It is worthy reporting that there is an increasing interest toward the exploitation of silver nanoparticles technology in the development of
https://ejchem.journals.ekb.eg/article_1106_148eae93a1cce44bdb15a796b085717a.pdf
2013-04-30
169
185
10.21608/ejchem.2013.1106