%0 Journal Article %T In Vitro Evaluation Of Antioxidant And Cytotoxic Activity Of Isolated Compounds From Pittosporum Eugenioides %J Egyptian Journal of Chemistry %I National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT %Z 0449-2285 %A Hamed, Manal Mortady %A Refahy, Lailal Abdel-Ghany %A Shafei, Azza Abbas %A Abd El Aziz, Eman Gamal %D 2022 %\ 10/01/2022 %V 65 %N 10 %P 321-328 %! In Vitro Evaluation Of Antioxidant And Cytotoxic Activity Of Isolated Compounds From Pittosporum Eugenioides %K Pittosporum eugenioides %K Antioxidant activity %K Cytotoxic activity %K (DPPH) %K Artemia salina L %R 10.21608/ejchem.2022.117564.5311 %X Ten compounds were isolated from the n-butanol extract of Pittosporum eugenioides leaves and evaluated for their antioxidant properties and cytotoxic activity. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical using ascorbic acid as standard antioxidant and total antioxidant capacity (TAC) (phosphomolybdenum assay). The overall antioxidant activity of compounds 1, 2, 3 and 4 showed the strongest one among the tested compounds with values of 1.28±0.97, 3.21±0.24, 5.40±0.08 and 7.09±0.07 μg/ml, respectively compared to the SC50 value of the positive ascorbic acid control was 7.9±0.78 μg/ml. Also, these compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina L.). The LC50 values ranged between 11 to 25 μg/ml, for the compounds 1-10. The present study reveals that the selected plants would exert several beneficial effects by virtue of their antioxidant and cytotoxic activity and could be harnessed as drug formulation. %U https://ejchem.journals.ekb.eg/article_217683_e07689c3d77c666a4723ea8206cf93e9.pdf