%0 Journal Article %T Metal Pharmacologically Active Agents: Mode of New Tridentate Glycine amino acid with diketone (Benzil) and 4- Amino antipyrine Complexes %J Egyptian Journal of Chemistry %I National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT %Z 0449-2285 %A Al Wagaa, Fatima Ali %A Ahmed,  Sahbaa Ali %D 2022 %\ 05/01/2022 %V 65 %N 5 %P 59-67 %! Metal Pharmacologically Active Agents: Mode of New Tridentate Glycine amino acid with diketone (Benzil) and 4- Amino antipyrine Complexes %K Glycine amino acid %K Schiff base 4-Amino antipyrine %K Metal complexes %K Benzil %K Antibacterial %R 10.21608/ejchem.2021.70792.3560 %X The paper presents the synthesis of complex combinations of Co(II), Ni(II), Cu(II), and Cd(II) with Schiff base obtained by the condensation reaction of 4-aminoantipyrine with benzil (diketone) and glycine amino acid. All complexes via direct reactions of metal ions with ligand in (1:2) molar ratio respectively. These complexes have been characterized via a variety of physiochemical techniques include elemental analyses (CHN), 1H-NMR, (IR), (UV-Vis), molar conductance, magnetic moment measurement, thermal gravimetric analysis (TGA), XRD, and computational chemistry. Infrared spectra; shows that the ligand behaves as a tridentate ligand and is coordinated through N, N, O as a donor atoms sequence towards the metal ions. Consequently, all the complexes showed octahedral shapes. Finally, the synthesized Schiff base and metal complexes were screened for their biological activity against bacterial species, one gram-positive bacteria (Staphylococcus aureus), and three gram-negative bacteria Pseudomonas aereuguinosa, Escherichia coli, and Klebsiella pneumonia. These compounds show the different activity of inhibition on the growth of the bacteria respectively. %U https://ejchem.journals.ekb.eg/article_204457_173362040851cf3bb07c2f28fa9e7960.pdf