@article { author = {Rashwan, Doaa and abd el hamed, may and El-deen, Mohamed and afify, mei and mohamed, mona and mohamed, abd el razik and Nagy, Rana and A. Elhakim, Heba}, title = {Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma}, journal = {Egyptian Journal of Chemistry}, volume = {65}, number = {4}, pages = {197-207}, year = {2022}, publisher = {National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT}, issn = {0449-2285}, eissn = {2357-0245}, doi = {10.21608/ejchem.2021.91841.4361}, abstract = {Nanoparticles can be synthesized by chemical, physical and biological system methods. In this work, Superparamagnetic Iron Oxide@Silver nanoparticles (SPION@Ag NPs) were modified by zinc oxide nanoparticles (ZnO NPs). SPION@Ag core shell NPs were synthesized by the biological method using Fusarium oxysporum fungus and coated with ZnO NPs. This method is eco-friendly and low cost. Characterization techniques such as UV, FTIR, HR-TEM, HR-SEM, XRD and zeta potential were used. The most common type of liver cancer is hepatocellular carcinoma (HCC). Hepatocellular carcinoma was induced by a single dose of diethyl nitrosamine (DEN) 60 mg/Kg b.wt. and was followed after two days with carbon tetra chloride (CCl4) diluted with paraffin oil (50% v/v, 2 ml/Kg b.wt.) twice a week for one month. A histopathology examination was done after scarifying. Clear changes were shown in the comparison between the HCC group treated with ZnO@SPION@Ag nanocomposite and the positive control group. Liver function tests showed a highly significant decrease after using the nanocomposite for HCC treatment. Our study aim is to evaluate the therapeutic anticancer effect of ZnO@SPION@Ag nanocomposite on hepatocellular carcinoma in male albino rats, which was synthesized by a new method called green chemistry or green synthesis.}, keywords = {Hepatocellular carcinoma,Drug delivery,Zinc Oxide,Nanocomposite,Anticancer}, url = {https://ejchem.journals.ekb.eg/article_197961.html}, eprint = {https://ejchem.journals.ekb.eg/article_197961_7b9fb4fb22583ef2b9f1c6b2e40accf4.pdf} }