Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate
text
article
2010
eng
ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate or formamide afforded -2- propylquinazolin-4(3H)-one (3). Behaviour of quinazolinone towards carbon electrophiles namely, aromatic aldehyde, chloroacetylchloride, and ethylchloroacetate has been investigated and all the synthesized compounds were tested as anti-cancer in National Cancer Institute (NCI) in USA.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
777
790
https://ejchem.journals.ekb.eg/article_1263_2a1db490356d4e65980ef0045f523a36.pdf
dx.doi.org/10.21608/ejchem.2010.1263
Can HCV RNA Be Detected in Saliva of Egyptian Children Receiving Frequent Blood Transfusions?
text
article
2010
eng
HEPATITIS C virus (HCV) infection is considered a major public health problem all over the world, especially in Egypt. Blood is almost the only route for HCV diagnosis. It has been reported that HCV could be detected in body fluids including saliva which represents an easier route than blood especially in infants and children. This study aimed to: 1) Assess the prevalence of HCV infection among high risk group of Egyptian children. 2) Evaluate the detection of HCV antibodies (anti-HCV) and HCV RNA in saliva against their detection in serum among HCV positive children. Patients and methods: this study included 200 children (92 males and 108 females) who were attendants of Haematology Clinic at Abu El-Reish Hospital, Faculty of Medicine, Cairo University, they were receiving frequent blood transfusions during their treatment. Serum and saliva samples were analyzed for detection of anti-HCV by ELISA technique and for HCV RNA by a home made RT-PCR method. Liver function tests were performed also. Results of serum samples revealed that 134/200 (67%) children were anti-HCV seropositive, out of them 79/134 (59%) children had HCV RNA in their sera. Saliva samples of HCV infected children (n=79) showed that 53/79 (67.1%) and 31/79 (39.2%) were anti -HCV and HCV RNA positive, respectively. Prevalence of HCV infection was 39.5% of 200 studied children. We can conclude that: 1) Prevalence of HCV infection among the studied children is considered high. 2) Saliva could play a possible role of biological fluids as a non parenteral route of intrafamilial spread of HCV infection. 3) More sensitive techniques could be developed to use saliva as a reliable route for HCV detection.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
791
802
https://ejchem.journals.ekb.eg/article_1264_826e9505559aef71a31a99f179806247.pdf
dx.doi.org/10.21608/ejchem.2010.1264
New Purine Derivatives of Potential Plant-Growth Regulating Properties
text
article
2010
eng
2-(CHLOROMETHYL)-purine-6(9 H)-one (3) was synthesized from reaction of the 5-amino-imidazole-4-carboxamide 1 with 2-chloroacetyl chloride. Also, products 4-7 were obtained from reacting 3 with different reagents. Treatment of 1 with ethyl chloroformate / DMF reagent mixture afforded 9-aryl-1,9-dihydro-6H-purin-6-one (9). Product 9 when reacted with some alkyl iodides gave 7-alkylpurinium iodide salts (10) rather than the expected products of type 11 or 12. N-substituted – purin -6- amines 14a-g, N1-(purin-6-yl) - benzene-1,2-diamine 14h and hydrazide 14i were synthesized upon treating product 9 with phosphoryl chloride followed by reaction with some selected amines or hydrazides . Screening for selected examples from the synthesized products 14 towards wheat plant growth regulation was reported.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
803
820
https://ejchem.journals.ekb.eg/article_1265_edacabc4aa817c6b023bf26134fcc873.pdf
dx.doi.org/10.21608/ejchem.2010.1265
Synthesis, Spectroscopic and Biological Characterization of Cr(III), Mn(II), Co(II), Ni(II) and Cu(II) Complexes with New Macrocyclic Tetradentate [N4] Schiff Base Ligands
text
article
2010
eng
THE SYNTHESES of three novel tetradentate Schiff base ligands, i.e. L1 = BBICI = benzo [1",2"-2,1] benzo [1"',2"'-8,7] indolo [3',2'-4,5] cyclododeca [10,11-b] indole, L2 = DBBICI = 4, 13 – dimethylbenzo [1",2"-2,1]benzo [1"',2"'-8,7]indolo[3',2'-4,5] cyclo- dodeca[10,11-b]indole and L3=HHPPA= 10, 11, 12, 23, 24, 25-hexahydrophenanthro [9,10-a] phenanthro [9,10-h] [14] annulene and their novel complexes with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Cd(II) have been reported. The complexes are characterized by the elemental and thermal analyses, molar conductance and magnetic susceptibility ,1HNMR, IR and UV-Vis spectral also were studied. Cr(III), Mn(II), Co(II), Ni(II), Cd(II) and Cu(II) chloride and nitrate complexes have octahedral geometries while Cu(II) acetato complex has distorted octahedral leading to tetragonal geometry. The biological activities of the ligands and complexes have been screened in vitro against some bacteria and fungi to investigate their capacity to inhibit their growth.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
821
845
https://ejchem.journals.ekb.eg/article_1266_23d95bc65c453df457bcac21ed6277e9.pdf
dx.doi.org/10.21608/ejchem.2010.1266
Physical Modification of Lyocell® and Modal® Fabrics and its Effect on Fabric Dyeability
text
article
2010
eng
THE EFFECT of some swelling agents; Viz. alkali metal hydroxides, alkaline earth metal salt and heavy metal salt, on the dyeability of lyocell and modal fabrics with reactive and direct dyes was monitored. The dyeing characteristics; namely colour strength, dyeing isotherm, diffusion coefficient, dyeing rate constant and half dyeing time of the dyed fabrics were assessed. The colour strength of the dyed samples increased in the order ZnCl 2 > MgCl2> NaOH > KOH > untreated. The fastness properties of the dyed fabrics were investigated. X-ray diffraction patterns of both untreated as well as treated fabrics were used to assign the change in the fine structure of the swollen lyocell and modal fibres relative to their respective untreated ones. The water retention capacity of lyocell and modal fabrics was calculated to deduce the degree of crystallinty of treated as well as untreated lyocell and modal fabrics.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
847
869
https://ejchem.journals.ekb.eg/article_1267_0e1f8317cc10ac2b0f64ee13f5041d1d.pdf
dx.doi.org/10.21608/ejchem.2010.1267
Kinetics of Thermal Decomposition of Iron Carbonate
text
article
2010
eng
THE THERMAL decomposition of iron cabonate in air was ……studied by means of DTA-TG, XRD, SEM and Mossbauer measurements. The kinetics of the thermal decomposition process were studied using isothermal and non-isothermal thermogravimetric techniques. The results show that the thermal decomposition proceeds in one step to iron oxide. Kinetic analysis of isothermal data of the decomposition reaction in the light of various solid state reaction models revealed that the reaction is best described by the diffusion models. Kinetic analysis of the dynamic TG curves were discussed with reference to Diefallah’s composite integral method, in comparison with the integral methods due to Coats-Redfern and to Ozawa. The activation parameters were calculated and the results of the isothermal and dynamic integral methods which were compared to each other were discussed.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
871
884
https://ejchem.journals.ekb.eg/article_1268_82097e00ce1c4e475f17cfec61edb6d2.pdf
dx.doi.org/10.21608/ejchem.2010.1268
Rapid and Simple Spectrophotometric Determination of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) Ions in Natural Samples Using 2-(2-Hydroxynaphth-1-ylazo)-pyridine
text
article
2010
eng
THE MEDIUM effect on the electronic absorption spectra of 2-(2-hydroxynaph-1-ylazo)-pyridine (HL) was studied. 2-(2-hydroxynaph-1-ylazo)-pyridine has been found to be a good chromogenic reagent for determination of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) ions. In aqueous buffer solution of different pH values (2-12) containing 30 % (v/v) methanol-water, HL reacts with Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) ions to form 1:1 and 1:2 (M:L) chelates. The formed complexes exhibiting absorption maxima at 580, 555, 577, 561 and 551 nm with apparent molar absorptivities 2.42 x 10 4, 0.58 x 104, 2.14 x 104, 4.54 x 104 and 2.09 x 104 (L mol-1 cm-1) for Mn(II), Fe(III), Co(II), Ni(II) and Cu(II)-complexes, respectively. The optimum conditions (pH, time, temperature, reagent concentration, sequence of addition and solvent ratio) for chelates formation are studied. The spectrophotometeric analytical characteristics (linearity ranges, Ringbom ranges, stability constants and free energy changes) of the formed complexes are determined. Relatively large amounts of co-existing elements, including all other metals, can be tolerated. The advantages of this method are: simple and rapid, with high sensitivity and good selectivity and was applied to the determination of the mentioned metal ions in natural samples with satisfactory results. Some solid HL-complexes are prepared and studied by different analytical and spectral techniques in order to investigate the mode of bonding in the formed complexes.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
885
902
https://ejchem.journals.ekb.eg/article_1269_3daea7301f8532ba5554fae84c5cd15e.pdf
dx.doi.org/10.21608/ejchem.2010.1269
Synthesis of Eco-Friendly Binders from Natural Resources Using Microwave and their Applications in Textile Printing
text
article
2010
eng
DIFFERENT oil length alkyd resins based on sunflower were ........prepared using microwave heating .the effect of oil length as well as using different catalysts on the .properties of alkyd resin such as acid value, Tg, solubility and IR data were evaluated. In case of using microwave heating the formation of alkyd resin occurred after 45-60min, while on using conventional heating the reaction duration ranged from 8-10 hr. Also, the prepared alkyds and commercial binder were used separately in the formulation of pigment printing pastes, and the properties of printed fabrics using the prepared binders were found to be comparable with samples printed using the commercial binder.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
903
921
https://ejchem.journals.ekb.eg/article_1270_d02a21f17f25bf8a3e1b1dd89ec17062.pdf
dx.doi.org/10.21608/ejchem.2010.1270
Effect of Refining Processes on Magnitude and Nature of Fenitrothion and Pirimiphos-Methyl Residues in Maize Oil and Bioavailability of their Cake Residues on Rats*
text
article
2010
eng
MAIZE seeds obtained from 14C-fenitrothion or 14C-pirimiphos-methyl treated maize plants contained about 0.12 % and 0.16 % of the originally applied radioactivity, respectively. The concentration of 14C-fenitrothion residues and 14C-pirimiphos-methyl residues in crude oil (hexane extract) ranged from 2.8-3.0 ppm, methanol solubles 2.3 ppm and in seed cake 1.2-1.4 ppm. Commercial processing procedures led to a gradual decrease in the total amount of 14C-residues in oils with aged residues. The refined oil contained only about 13-19% of the radioactivity originally present. The deodorization and alkali treatment are the most effective steps as they removed over 50 % of the residues. Chromatographic analysis of refined oil revealed the presence of fenitrothion, 3-methyl-4-nitrophenol as main products beside smaller amounts of fenitrooxon and desmethyl fenitrothion. Whereas, pirimiphos-methyl and 2-diethyl-2-amino-4-hydroxy-6-methylpyrimidine were detected as principal compounds together with minor amounts of 2-ethyl-amino-4-hydroxy-6-methylpyrimidine and 2-amino-4-hydroxy-6-methyl-pyrimidine.
On feeding rats with the extracted seeds (cake) for three days, the bound residues were found to be considerably bioavailable. A substantial amount of administrated bound
14C-residues was eliminated via respiration (50%) for 14C-fenitrothion and excreted urine (47%) for 14C-pirimiphos-methyl. While feces contained only 10-12% and about 22-26% of the radioactive residues were distributed among various organs of experimental animals.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
923
938
https://ejchem.journals.ekb.eg/article_1271_9f8f7d6340f6934bab3eb0e4f8c06d4a.pdf
dx.doi.org/10.21608/ejchem.2010.1271
Synthesis of Highly Soluble Fluoro Containing Metal -phthalocyanines and (Hexafluoroisopropylidene) -bridged Metal-phthalocyanine Polymers
text
article
2010
eng
NOVEL soluble peripherally tetrasubstituted metal-phthalocyanines: 2(3),9 10), ……16 (17),23(24) – tetrakis - 2'-(4-hexafluoroisopropylidene-phthalic acid)-phthalocyanines [(R4Pc)M] where R= (4,4`-(hexafluoroisopropylidene) bis-phthalic acid and M= Co(II), Ni(II) and Cu(II) 2-4, have been prepared. Additionally, the soluble hexafluoroisopropylidene bridged high molecular weight phthalocyanines 5-7 were obtained by controlling the reaction conditions such as molar ratio of the reactant, reaction time and temperature. Structural and spectral investigations (FAB-MS, MALDI-TOF-MS, 1H-NMR, atomic absorption spectroscopy (AAS), elemental analysis, UV/Vis, FTIR, TGA, and GPC) of the prepared phthalocyanines revealed some interesting observations.
Egyptian Journal of Chemistry
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
0449-2285
53
v.
6
no.
2010
939
954
https://ejchem.journals.ekb.eg/article_1272_05e43b8f3ff2834fdef7ad2f33c5e0a5.pdf
dx.doi.org/10.21608/ejchem.2010.1272