Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA)

Document Type : Original Article

Authors

1 polymers and pigments dept. national research centre

2 Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt,

3 Analytical Toxicology Laboratory, Forensic Medicine Authority, Ministry of Justice, Cairo, Egypt.

4 Glass Research Department, National Research Center, 33 El Bohoth St.,Dokki, Giza, Egypt.

5 Faculty of Science, Al-Azhair University

Abstract

A simple method for adsorption and recognition of tramadol-HCl in molecular imprinted poly (methacrylic acid-co-ethylene glycol dimethacrylate); poly (MAA-co-EGDMA), is described. Seven tramadol imprinted polymers (TIPs) were synthesized based on tramadol hydrochloride as the template molecule, methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, chloroform as a porogenic solvent and benzoyl peroxide (BP) as an initiator. Other seven non-imprinted polymers (NIPs) were prepared with the same compositions as the TIPs without the template molecule. A simple method for determination of Tramadol concentration by optical absorption method was described. The effects of crosslinker and functional monomer concentration, soaking time and the pH on the adsorption efficiency of tramadol by the polymers were studied. TIPs exhibited more adsorption affinity than their NIPs counterparts as they acquired recognition sites to capture the tramadol molecules. The TIP polymer with 15 mmol EGDMA and 1.15 mmol MAA stirred for 3h at 7 pH tramadol solution showed 90% adsorption capability for the tramadol, while the corresponding NIP sample showed 55.6% adsorption. SEM images showed the presence of (micro/meso/macro) pores in such TIP sample.

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History

  • Receive Date: 16 March 2020
  • Revise Date: 24 April 2020
  • Accept Date: 10 May 2020

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